Association and prediction of severe 5-fluorouracil toxicity with dihydropyrimidine dehydrogenase gene polymorphisms: A meta-analysis

  • Authors:
    • Henry W.C. Leung
    • Agnes L.F. Chan
  • View Affiliations

  • Published online on: August 28, 2015     https://doi.org/10.3892/br.2015.513
  • Pages: 879-883
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Abstract

The aim of the present study was to evaluate the association and prediction of dihydropyrimidine dehydrogenase gene (DPYD) polymorphisms and the risk of 5‑fluorouracil (5‑FU) severe toxicity in cancer patients. A meta‑analysis of the published literature was conducted to summarize evidence for DPYD gene polymorphisms associated with an increased risk of severe 5‑FU toxicity in patients with cancer from an Asian population. Relevant literature was identified using the PubMed and Cochrane databases on April 11, 2014. Combined risk ratios and 95% confidence intervals (CIs) were calculated in a fixed‑effects model. A total of 5 clinical studies were retrieved in the meta‑analysis, including 764 cancer patients with DPYD gene polymorphisms who received 5‑FU‑based chemotherapy. Overall, DPYD gene polymorphisms were associated with the increased risk of 5‑FU severe toxicity [risk ratio=2.54 (2.15-3.00); 95% CI, 19.46‑84.57; P=0.0001]. In conclusion, the present meta‑analysis suggested that polymorphisms of several DPYD gene polymorphisms are associated with an increased risk of severe toxic response to 5-FU.
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November-2015
Volume 3 Issue 6

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Leung HW and Chan AL: Association and prediction of severe 5-fluorouracil toxicity with dihydropyrimidine dehydrogenase gene polymorphisms: A meta-analysis. Biomed Rep 3: 879-883, 2015.
APA
Leung, H.W., & Chan, A.L. (2015). Association and prediction of severe 5-fluorouracil toxicity with dihydropyrimidine dehydrogenase gene polymorphisms: A meta-analysis. Biomedical Reports, 3, 879-883. https://doi.org/10.3892/br.2015.513
MLA
Leung, H. W., Chan, A. L."Association and prediction of severe 5-fluorouracil toxicity with dihydropyrimidine dehydrogenase gene polymorphisms: A meta-analysis". Biomedical Reports 3.6 (2015): 879-883.
Chicago
Leung, H. W., Chan, A. L."Association and prediction of severe 5-fluorouracil toxicity with dihydropyrimidine dehydrogenase gene polymorphisms: A meta-analysis". Biomedical Reports 3, no. 6 (2015): 879-883. https://doi.org/10.3892/br.2015.513