Open Access

Role of several histone lysine methyltransferases in tumor development (Review)

  • Authors:
    • Jifu Li
    • Shunqin Zhu
    • Xiao-Xue Ke
    • Hongjuan Cui
  • View Affiliations

  • Published online on: January 21, 2016     https://doi.org/10.3892/br.2016.574
  • Pages: 293-299
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The field of cancer epigenetics has been evolving rapidly in recent decades. Epigenetic mechanisms include DNA methylation, histone modifications and microRNAs. Histone modifications are important markers of function and chromatin state. Aberrant histone methylation frequently occurs in tumor development and progression. Multiple studies have identified that histone lysine methyltransferases regulate gene transcription through the methylation of histone, which affects cell proliferation and differentiation, cell migration and invasion, and other biological characteristics. Histones have variant lysine sites for different levels of methylation, catalyzed by different lysine methyltransferases, which have numerous effects on human cancers. The present review focused on the most recent advances, described the key function sites of histone lysine methyltransferases, integrated significant quantities of data to introduce several compelling histone lysine methyltransferases in various types of human cancers, summarized their role in tumor development and discussed their potential mechanisms of action.
View Figures
View References

Related Articles

Journal Cover

March-2016
Volume 4 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Zhu S, Ke X and Cui H: Role of several histone lysine methyltransferases in tumor development (Review). Biomed Rep 4: 293-299, 2016.
APA
Li, J., Zhu, S., Ke, X., & Cui, H. (2016). Role of several histone lysine methyltransferases in tumor development (Review). Biomedical Reports, 4, 293-299. https://doi.org/10.3892/br.2016.574
MLA
Li, J., Zhu, S., Ke, X., Cui, H."Role of several histone lysine methyltransferases in tumor development (Review)". Biomedical Reports 4.3 (2016): 293-299.
Chicago
Li, J., Zhu, S., Ke, X., Cui, H."Role of several histone lysine methyltransferases in tumor development (Review)". Biomedical Reports 4, no. 3 (2016): 293-299. https://doi.org/10.3892/br.2016.574