Analysis of drug resistance in 1,861 strains of Acinetobacter baumannii
- Authors:
- Hao Jin
- Fan Qiu
- Hong Jian Ji
- Qiang Lu
View Affiliations
Affiliations: Department of Clinical Laboratory, Yancheng Third People's Hospital, Yancheng, Jiangsu 224005, P.R. China, Department of Pharmacy, Yancheng Vocational Institute of Health Science, Yancheng, Jiangsu 224005, P.R. China
- Published online on: February 15, 2016 https://doi.org/10.3892/br.2016.598
-
Pages:
463-466
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
Acinetobacter baumannii is an emerging human pathogen that causes hospital-acquired infections. The trend in increased antimicrobial resistance limits the choice of effective antimicrobial agents. The present study reports the resistance to Acinetobacter baumannii and analyzes the associations between antibiotic use and resistance rates at a general hospital between 2010 and 2014. A total of 1,861 isolates were obtained from clinical cultures, accounting for 10.33% of all detected bacteria (1,861/18,016). The strains were mainly from respiratory samples (1,628 isolates, 87.5%) and the intensive care unit (696 isolates, 37.4%). The resistance rates of Acinetobacter baumannii to the majority of antibiotics were >50%, particularly the resistance rate to cefoperazone/sulbactam increased from 47.37 in 2011 to 89.25% in 2014. However, the rates of imipenem and cilastatin sodium decreased from 81.03 to 69.44% due to the antibiotic policy. There were Pearson significant associations between the use of three antibiotics and resistance in Acinetobacter baumannii to this drug, piperacillin/tazobactam (r=0.976, P<0.01), gentamicin (r=0.870, P<0.01) and cefoxitin (r=0.741, P<0.05). Therefore, a combination of drugs should be adopted to treat Acinetobacter baumannii infections. Microbiology laboratory support and surveillance policies are essential to control the emergence of multidrug-resistance Acinetobacter baumannii.
View References
|
1
|
Jones CL, Clancy M, Honnold C, Singh S,
Snesrud E, Onmus-Leone F, McGann P, Ong AC, Kwak Y, Waterman P, et
al: Fatal outbreak of an emerging clone of extensively
drug-resistant Acinetobacter baumannii with enhanced
virulence. Clin Infect Dis. 61:145–154. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Shields RK, Clancy CJ, Gillis LM, Kwak EJ,
Silveira FP, Massih RC, Eschenauer GA, Potoski BA and Nguyen MH:
Epidemiology, clinical characteristics and outcomes of extensively
drug-resistant Acinetobacter baumannii infections among
solid organ transplant recipients. PLoS One. 7:e523492012.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Snitkin ES, Zelazny AM, Montero CI, Stock
F, Mijares L, Murray PR, Segre JA, Mullikin J, Blakesley R, Young
A, et al: NISC Comparative Sequence Program: Genome-wide
recombination drives diversification of epidemic strains of
Acinetobacter baumannii. Proc Natl Acad Sci USA.
108:13758–13763. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Vilacoba E, Almuzara M, Gulone L,
Rodriguez R, Pallone E, Bakai R, Centrón D and Ramírez MS: Outbreak
of extensively drug-resistant Acinetobacter baumannii
indigo-pigmented strains. J Clin Microbiol. 51:3726–3730. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Xu J, Sun Z, Li Y and Zhou Q: Surveillance
and correlation of antibiotic consumption and resistance of
Acinetobacter baumannii complex in a tertiary care hospital
in northeast China, 2003–2011. Int J Environ Res Public Health.
10:1462–1473. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Mihu MR, Sandkovsky U, Han G, Friedman JM,
Nosanchuk JD and Martinez LR: The use of nitric oxide releasing
nanoparticles as a treatment against Acinetobacter baumannii
in wound infections. Virulence. 1:62–67. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
DeLeon K, Balldin F, Watters C, Hamood A,
Griswold J, Sreedharan S and Rumbaugh KP: Gallium maltolate
treatment eradicates Pseudomonas aeruginosa infection in thermally
injured mice. Antimicrob Agents Chemother. 53:1331–1337. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Hwang YY, Ramalingam K, Bienek DR, Lee V,
You T and Alvarez R: Antimicrobial activity of nanoemulsion in
combination with cetylpyridinium chloride in multidrug-resistant
Acinetobacter baumannii. Antimicrob Agents Chemother.
57:3568–3575. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Chen J, Li H, Yang J, Zhan R, Chen A and
Yan Y: Prevalence and Characterization of Integrons in Multidrug
Resistant Acinetobacter baumannii in Eastern China: A
Multiple-Hospital Study. Int J Environ Res Public Health.
12:10093–10105. 2015. View Article : Google Scholar : PubMed/NCBI
|
