Role of physical exercise in Alzheimer's disease (Review)
- Authors:
- Wei‑Wei Chen
- Xia Zhang
- Wen‑Juan Huang
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Affiliations: Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China - Published online on: February 22, 2016 https://doi.org/10.3892/br.2016.607
- Pages: 403-407
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Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Baker LD, Frank LL, Foster-Schubert K, Green PS, Wilkinson CW, McTiernan A, Plymate SR, Fishel MA, Watson GS, Cholerton BA, et al: Effects of aerobic exercise on mild cognitive impairment: A controlled trial. Arch Neurol. 67:71–79. 2010. View Article : Google Scholar : PubMed/NCBI | |
Radak Z, Zhao Z, Koltai E, Ohno H and Atalay M: Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling. Antioxid Redox Signal. 18:1208–1246. 2013. View Article : Google Scholar : PubMed/NCBI | |
van Praag H, Fleshner M, Schwartz MW and Mattson MP: Exercise, energy intake, glucose homeostasis, and the brain. J Neurosci. 34:15139–15149. 2014. View Article : Google Scholar : PubMed/NCBI | |
Gertz K, Priller J, Kronenberg G, Fink KB, Winter B, Schröck H, Ji S, Milosevic M, Harms C, Böhm M, et al: Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow. Circ Res. 99:1132–1140. 2006. View Article : Google Scholar : PubMed/NCBI | |
Zoladz JA and Pilc A: The effect of physical activity on the brain derived neurotrophic factor: From animal to human studies. J Physiol Pharmacol. 61:533–541. 2010.PubMed/NCBI | |
Garuffi M, Costa JLR, Hernández SSS, Vital TM, Stein AM, dos Santos JG and Stella F: Effects of resistance training on the performance of activities of daily living in patients with Alzheimer's disease. Geriatr Gerontol Int. 13:322–328. 2013. View Article : Google Scholar : PubMed/NCBI | |
Bow C, Cheung C, Gao Y, Xiao S, Lau K, Soong C, Yeung S and Kung A: Bone mineral density and serum osteoprotegerin levels in pre-and post-menopausal women. Hong Kong Med J. 17:92011. | |
American College of Sports Medicine: American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc. 41:687–708. 2009. View Article : Google Scholar : PubMed/NCBI | |
Laurin D, Verreault R, Lindsay J, MacPherson K and Rockwood K: Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 58:498–504. 2001. View Article : Google Scholar : PubMed/NCBI | |
Hurley BF, Hanson ED and Sheaff AK: Strength training as a countermeasure to aging muscle and chronic disease. Sports Med. 41:289–306. 2011. View Article : Google Scholar : PubMed/NCBI | |
Burns JM, Johnson DK, Watts A, Swerdlow RH and Brooks WM: Reduced lean mass in early Alzheimer disease and its association with brain atrophy. Arch Neurol. 67:428–433. 2010. View Article : Google Scholar : PubMed/NCBI | |
Boyle PA, Buchman AS, Wilson RS, Leurgans SE and Bennett DA: Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons. Arch Neurol. 66:1339–1344. 2009. View Article : Google Scholar : PubMed/NCBI | |
Taaffe DR, Irie F, Masaki KH, Abbott RD, Petrovitch H, Ross GW and White LR: Physical activity, physical function, and incident dementia in elderly men: The Honolulu-Asia Aging Study. J Gerontol A Biol Sci Med Sci. 63:529–535. 2008. View Article : Google Scholar : PubMed/NCBI | |
Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, et al: Revising the definition of Alzheimer's disease: A new lexicon. Lancet Neurol. 9:1118–1127. 2010. View Article : Google Scholar : PubMed/NCBI | |
Zhao Y and Zhao B: Oxidative stress and the pathogenesis of Alzheimer's disease. Oxid Med Cell Longev. 2013:3165232013.PubMed/NCBI | |
Castellani R, Hirai K, Aliev G, Drew KL, Nunomura A, Takeda A, Cash AD, Obrenovich ME, Perry G and Smith MA: Role of mitochondrial dysfunction in Alzheimer's disease. J Neurosci Res. 70:357–360. 2002. View Article : Google Scholar : PubMed/NCBI | |
Zhang C, Rissman RA and Feng J: Characterization of ATP alternations in an Alzheimer's disease transgenic mouse model. J Alzheimers Dis. 44:375–378. 2015.PubMed/NCBI | |
Kwiatkowski D, Czarny P, Galecki P, Bachurska A, Talarowska M, Orzechowska A, Bobińska K, Bielecka-Kowalska A, Pietras T, Szemraj J, et al: Variants of Base Excision Repair Genes MUTYH, PARP1 and XRCC1 in Alzheimer's Disease Risk. Neuropsychobiology. 71:176–186. 2015. View Article : Google Scholar : PubMed/NCBI | |
Gandhi S and Abramov AY: Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev. 2012:4280102012.PubMed/NCBI | |
Ito E, Oka K, Etcheberrigaray R, Nelson TJ, McPhie DL, Tofel-Grehl B, Gibson GE and Alkon DL: Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc Natl Acad Sci USA. 91:534–538. 1994. View Article : Google Scholar : PubMed/NCBI | |
da Silva, Oliveira GL and de Freitas RM: Potential involvement of oxidative stress in induction of neurodegenerative diseases: Actions, mechanisms and neurotherapeutic potential of natural antioxidants. Afr J Pharm Pharmacol. 8:685–700. 2014. | |
Gerenu G, Liu K, Chojnacki JE, Saathoff JM, Martínez-Martín P, Perry G, Zhu X, Lee HG and Zhang S: Curcumin/melatonin hybrid 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide ameliorates AD-like pathology in the APP/PS1 mouse model. ACS Chem Neurosci. 6:1393–1399. 2015. View Article : Google Scholar : PubMed/NCBI | |
Butterfield DA, Drake J, Pocernich C and Castegna A: Evidence of oxidative damage in Alzheimer's disease brain: Central role for amyloid β-peptide. Trends Mol Med. 7:548–554. 2001. View Article : Google Scholar : PubMed/NCBI | |
Chamorro A, Pujol J, Saiz A, Vila N, Vilanova JC, Alday M and Blanc R: Periventricular white matter lucencies in patients with lacunar stroke. A marker of too high or too low blood pressure? Arch Neurol. 54:1284–1288. 1997.PubMed/NCBI | |
Pantoni L: Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 9:689–701. 2010. View Article : Google Scholar : PubMed/NCBI | |
Aguero-Torres H, Kivipelto M and von Strauss E: Rethinking the dementia diagnoses in a population-based study: What is Alzheimer's disease and what is vascular dementia? A study from the kungsholmen project. Dement Geriatr Cogn Disord. 22:244–249. 2006. View Article : Google Scholar : PubMed/NCBI | |
Kalaria RN, Kenny RA, Ballard CG, Perry R, Ince P and Polvikoski T: Towards defining the neuropathological substrates of vascular dementia. J Neurol Sci. 226:75–80. 2004. View Article : Google Scholar : PubMed/NCBI | |
Mutrux S: Contribution to the differential histological study of dementia senilis & Alzheimer's disease. Psychiatr Neurol (Basel). 136:146–156. 1958.(In French). View Article : Google Scholar : PubMed/NCBI | |
Yamamoto Y, Craggs L, Baumann M, Kalimo H and Kalaria RN: Review: Molecular genetics and pathology of hereditary small vessel diseases of the brain. Neuropathol Appl Neurobiol. 37:94–113. 2011. View Article : Google Scholar : PubMed/NCBI | |
Tikka S, Baumann M, Siitonen M, Pasanen P, Pöyhönen M, Myllykangas L, Viitanen M, Fukutake T, Cognat E, Joutel A, et al: CADASIL and CARASIL. Brain Pathol. 24:525–544. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kalaria RN and Pax AB: Increased collagen content of cerebral microvessels in Alzheimer's disease. Brain Res. 705:349–352. 1995. View Article : Google Scholar : PubMed/NCBI | |
Schultz JJ, Witt SA, Glascock BJ, Nieman ML, Reiser PJ, Nix SL, Kimball TR and Doetschman T: TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. J Clin Invest. 109:787–796. 2002. View Article : Google Scholar : PubMed/NCBI | |
Rosenkranz S: TGF-beta1 and angiotensin networking in cardiac remodeling. Cardiovasc Res. 63:423–432. 2004. View Article : Google Scholar : PubMed/NCBI | |
Yurovsky VV, Gerzanich V, Ivanova S, Dong Y, Tsymbalyuk O and Simard JM: Autocrine TGF-beta1 mediates angiotensin II-induced proliferative response of cerebral vessels in vivo. Am J Hypertens. 20:950–956. 2007. View Article : Google Scholar : PubMed/NCBI | |
Ruiz-Ortega M, Rodríguez-Vita J, Sanchez-Lopez E, Carvajal G and Egido J: TGF-β signaling in vascular fibrosis. Cardiovasc Res. 74:196–206. 2007. View Article : Google Scholar : PubMed/NCBI | |
Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, Niedzielko TL, Schneider LE, Mastroeni D, Caselli R, et al: Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci USA. 105:4441–4446. 2008. View Article : Google Scholar : PubMed/NCBI | |
Yu F and Swartwood RM: Feasibility and perception of the impact from aerobic exercise in older adults with Alzheimer's disease. Am J Alzheimers Dis Other Demen. 27:397–405. 2012. View Article : Google Scholar : PubMed/NCBI | |
Yaffe K: Biomarkers of Alzheimer's disease and exercise: One step closer to prevention. Ann Neurol. 68:275–276. 2010. View Article : Google Scholar : PubMed/NCBI | |
Geda YE, Roberts RO, Knopman DS, Christianson TJ, Pankratz VS, Ivnik RJ, Boeve BF, Tangalos EG, Petersen RC and Rocca WA: Physical exercise, aging, and mild cognitive impairment: A population-based study. Arch Neurol. 67:80–86. 2010. View Article : Google Scholar : PubMed/NCBI | |
Archer T: Physical exercise alleviates debilities of normal aging and Alzheimer's disease. Acta Neurol Scand. 123:221–238. 2011. View Article : Google Scholar : PubMed/NCBI | |
Vidoni ED, Van Sciver A, Johnson DK, He J, Honea R, Haines B, Goodwin J, Laubinger MP, Anderson HS, Kluding PM, et al: A community-based approach to trials of aerobic exercise in aging and Alzheimer's disease. Contemp Clin Trials. 33:1105–1116. 2012. View Article : Google Scholar : PubMed/NCBI | |
Hill KD, LoGiudice D, Lautenschlager NT, Said CM, Dodd KJ and Suttanon P: Effectiveness of balance training exercise in people with mild to moderate severity Alzheimer's disease: Protocol for a randomised trial. BMC Geriatr. 9:292009. View Article : Google Scholar : PubMed/NCBI | |
Etnier JL, Nowell PM, Landers DM and Sibley BA: A meta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Res Brain Res Rev. 52:119–130. 2006. View Article : Google Scholar | |
Venturelli M, Scarsini R and Schena F: Six-month walking program changes cognitive and ADL performance in patients with Alzheimer. Am J Alzheimers Dis Other Demen. 26:381–388. 2011. View Article : Google Scholar : PubMed/NCBI | |
Winchester J, Dick MB, Gillen D, Reed B, Miller B, Tinklenberg J, Mungas D, Chui H, Galasko D, Hewett L, et al: Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year. Arch Gerontol Geriatr. 56:96–103. 2013. View Article : Google Scholar : PubMed/NCBI | |
Suttanon P, Hill KD, Said CM, Williams SB, Byrne KN, LoGiudice D, Lautenschlager NT and Dodd KJ: Feasibility, safety and preliminary evidence of the effectiveness of a home-based exercise programme for older people with Alzheimer's disease: A pilot randomized controlled trial. Clin Rehabil. 27:427–438. 2013. View Article : Google Scholar : PubMed/NCBI | |
McArdle WD, Katch FI and Katch VL: Exercise physiology: nutrition, energy, and human performance. Lippincott Williams & Wilkins. Philadelphia, PA: 2010. | |
McCurry SM, Pike KC, Vitiello MV, Logsdon RG, Larson EB and Teri L: Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer's disease: Results of a randomized, controlled trial. J Am Geriatr Soc. 59:1393–1402. 2011. View Article : Google Scholar : PubMed/NCBI | |
Abe K: Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology. 79:1071–1071; author reply 1071. 2012. View Article : Google Scholar : PubMed/NCBI | |
Buchman AS, Boyle PA, Yu L, Shah RC, Wilson RS and Bennett DA: Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology. 78:1323–1329. 2012. View Article : Google Scholar : PubMed/NCBI | |
Norton S, Matthews FE, Barnes DE, Yaffe K and Brayne C: Potential for primary prevention of Alzheimer's disease: An analysis of population-based data. Lancet Neurol. 13:788–794. 2014. View Article : Google Scholar : PubMed/NCBI | |
Pitkälä KH, Pöysti MM, Laakkonen ML, Tilvis RS, Savikko N, Kautiainen H and Strandberg TE: Effects of the Finnish Alzheimer disease exercise trial (FINALEX): A randomized controlled trial. JAMA Intern Med. 173:894–901. 2013. View Article : Google Scholar : PubMed/NCBI | |
Hamer M and Chida Y: Physical activity and risk of neurodegenerative disease: A systematic review of prospective evidence. Psychol Med. 39:3–11. 2009. View Article : Google Scholar : PubMed/NCBI | |
Um HS, Kang EB, Koo JH, Kim HT, Jin-Lee Kim EJ, Yang CH, An GY, Cho IH and Cho JY: Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease. Neurosci Res. 69:161–173. 2011. View Article : Google Scholar : PubMed/NCBI | |
Yu F, Kolanowski AM, Strumpf NE and Eslinger PJ: Improving cognition and function through exercise intervention in Alzheimer's disease. J Nurs Scholarsh. 38:358–365. 2006. View Article : Google Scholar : PubMed/NCBI | |
Rolland Y, Pillard F, Klapouszczak A, Reynish E, Thomas D, Andrieu S, Rivière D and Vellas B: Exercise program for nursing home residents with Alzheimer's disease: A 1-year randomized, controlled trial. J Am Geriatr Soc. 55:158–165. 2007. View Article : Google Scholar : PubMed/NCBI | |
Buschert V, Bokde AL and Hampel H: Cognitive intervention in Alzheimer disease. Nat Rev Neurol. 6:508–517. 2010.PubMed/NCBI | |
Cendoroglo MS, Thiessen EJ, Blake CM, Forbes SS and Forbes S: Exercise programs for people with dementia. Sao Paulo Med J. 132:195–196. 2014. View Article : Google Scholar : PubMed/NCBI | |
Scarmeas N, Luchsinger JA, Brickman AM, Cosentino S, Schupf N, Xin-Tang M, Gu Y and Stern Y: Physical activity and Alzheimer disease course. Am J Geriatr Psychiatry. 19:471–481. 2011. View Article : Google Scholar : PubMed/NCBI | |
Regan C, Katona C, Walker Z and Livingston G: Relationship of exercise and other risk factors to depression of Alzheimer's disease: The LASER-AD study. Int J Geriatr Psychiatry. 20:261–268. 2005. View Article : Google Scholar : PubMed/NCBI | |
Williams CL and Tappen RM: Exercise training for depressed older adults with Alzheimer's disease. Aging Ment Health. 12:72–80. 2008. View Article : Google Scholar : PubMed/NCBI | |
Williams CL and Tappen RM: Effect of exercise on mood in nursing home residents with Alzheimer's disease. Am J Alzheimers Dis Other Demen. 22:389–397. 2007. View Article : Google Scholar : PubMed/NCBI | |
Hernandez SS, Coelho FG, Gobbi S and Stella F: Effects of physical activity on cognitive functions, balance and risk of falls in elderly patients with Alzheimer's dementia. Rev Bras Fisioter. 14:68–74. 2010.(In Portuguese). View Article : Google Scholar : PubMed/NCBI | |
de Andrade LP, Gobbi LT, Coelho FG, Christofoletti G, Costa JL and Stella F: Benefits of multimodal exercise intervention for postural control and frontal cognitive functions in individuals with Alzheimer's disease: A controlled trial. J Am Geriatr Soc. 61:1919–1926. 2013. View Article : Google Scholar : PubMed/NCBI | |
Yuede CM, Zimmerman SD, Dong H, Kling MJ, Bero AW, Holtzman DM, Timson BF and Csernansky JG: Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease. Neurobiol Dis. 35:426–432. 2009. View Article : Google Scholar : PubMed/NCBI | |
Wolf SA, Kronenberg G, Lehmann K, Blankenship A, Overall R, Staufenbiel M and Kempermann G: Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease. Biol Psychiatry. 60:1314–1323. 2006. View Article : Google Scholar : PubMed/NCBI | |
Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR and Small SA: An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci USA. 104:5638–5643. 2007. View Article : Google Scholar : PubMed/NCBI | |
Lange-Asschenfeldt C and Kojda G: Alzheimer's disease, cerebrovascular dysfunction and the benefits of exercise: From vessels to neurons. Exp Gerontol. 43:499–504. 2008. View Article : Google Scholar : PubMed/NCBI | |
Colcombe SJ, Erickson KI, Scalf PE, Kim JS, Prakash R, McAuley E, Elavsky S, Marquez DX, Hu L and Kramer AF: Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci. 61:1166–1170. 2006. View Article : Google Scholar : PubMed/NCBI | |
Radak Z, Hart N, Sarga L, Koltai E, Atalay M, Ohno H and Boldogh I: Exercise plays a preventive role against Alzheimer's disease. J Alzheimers Dis. 20:777–783. 2010.PubMed/NCBI | |
Um HS, Kang EB, Leem YH, Cho IH, Yang CH, Chae KR, Hwang DY and Cho JY: Exercise training acts as a therapeutic strategy for reduction of the pathogenic phenotypes for Alzheimer's disease in an NSE/APPsw-transgenic model. Int J Mol Med. 22:529–539. 2008.PubMed/NCBI | |
Pérez CA and Cancela Carral JM: Benefits of physical exercise for older adults with Alzheimer's disease. Geriatr Nurs. 29:384–391. 2008. View Article : Google Scholar : PubMed/NCBI | |
van Praag H, Christie BR, Sejnowski TJ and Gage FH: Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci USA. 96:13427–13431. 1999. View Article : Google Scholar : PubMed/NCBI | |
Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, et al: Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA. 108:3017–3022. 2011. View Article : Google Scholar : PubMed/NCBI | |
Coelho FG, Vital TM, Stein AM, Arantes FJ, Rueda AV, Camarini R, Teodorov E and Santos-Galduróz RF: Acute aerobic exercise increases brain-derived neurotrophic factor levels in elderly with Alzheimer's disease. J Alzheimers Dis. 39:401–408. 2014.PubMed/NCBI | |
Belarbi K, Burnouf S, Fernandez-Gomez FJ, Laurent C, Lestavel S, Figeac M, Sultan A, Troquier L, Leboucher A, Caillierez R, et al: Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiol Dis. 43:486–494. 2011. View Article : Google Scholar : PubMed/NCBI | |
Leem YH, Lee YI, Son HJ and Lee SH: Chronic exercise ameliorates the neuroinflammation in mice carrying NSE/htau23. Biochem Biophys Res Commun. 406:359–365. 2011. View Article : Google Scholar : PubMed/NCBI | |
Schinder AF and Poo M: The neurotrophin hypothesis for synaptic plasticity. Trends Neurosci. 23:639–645. 2000. View Article : Google Scholar : PubMed/NCBI | |
Gottschalk WA, Jiang H, Tartaglia N, Feng L, Figurov A and Lu B: Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Learn Mem. 6:243–256. 1999.PubMed/NCBI | |
Colcombe S and Kramer AF: Fitness effects on the cognitive function of older adults: A meta-analytic study. Psychol Sci. 14:125–130. 2003. View Article : Google Scholar : PubMed/NCBI | |
Angevaren M, Aufdemkampe G, Verhaar H, Aleman A and Vanhees L: Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev. 3:CD0053812008.PubMed/NCBI | |
Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA, Welsh-Bohmer K, Browndyke JN and Sherwood A: Aerobic exercise and neurocognitive performance: A meta-analytic review of randomized controlled trials. Psychosom Med. 72:239–252. 2010. View Article : Google Scholar : PubMed/NCBI | |
Vaynman S, Ying Z and Gomez-Pinilla F: Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci. 20:2580–2590. 2004. View Article : Google Scholar : PubMed/NCBI |