Sensitization of Candida albicans to terbinafine by berberine and berberrubine

Lam,Pikling; Kok,Stanton Hon Lung; Lee,Kenneth Ka Ho; Lam,Kim Hung; Hau,Desmond Kwok Po; Wong,Wai Yeung; Bian,Zhaoxiang; Gambari,Roberto; Chui,Chung Hin

doi:10.3892/br.2016.608

Sensitization of Candida albicans to terbinafine by berberine and berberrubine

Authors:
- Pikling Lam
- Stanton Hon Lung Kok
- Kenneth Ka Ho Lee
- Kim Hung Lam
- Desmond Kwok Po Hau
- Wai Yeung Wong
- Zhaoxiang Bian
- Roberto Gambari
- Chung Hin Chui
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Affiliations: State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, SAR, P.R. China, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China, Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, SAR, P.R. China, Department of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, P.R. China, Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
Published online on: February 23, 2016 https://doi.org/10.3892/br.2016.608
Pages: 449-452

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Abstract

Candida albicans (C. albicans) is an opportunistic fungal pathogen, particularly observed in immunocompromised patients. C. albicans accounts for 50‑70% of cases of invasive candidiasis in the majority of clinical settings. Terbinafine, an allylamine antifungal drug, has been used to treat fungal infections previously. It has fungistatic activity against C. albicans. Traditional Chinese medicines can be used as complementary medicines to conventional drugs to treat a variety of ailments and diseases. Berberine is a quaternary alkaloid isolated from the traditional Chinese herb, Coptidis Rhizoma, while berberrubine is isolated from the medicinal plant Berberis vulgaris, but is also readily derived from berberine by pyrolysis. The present study demonstrates the possible complementary use of berberine and berberrubine with terbinafine against C. albicans. The experimental findings assume that the potential application of these alkaloids together with reduced dosage of the standard drug would enhance the resulting antifungal potency.

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