Effects of Dendropanax morbifera Léveille extracts on cadmium and mercury secretion as well as oxidative capacity: A randomized, double-blind, placebo-controlled trial

  • Authors:
    • Jae Sam Seo
    • Dae Young Yoo
    • Hyo Young Jung
    • Dong‑Woo Kim
    • In Koo Hwang
    • Jong Young Lee
    • Seung Myung Moon
  • View Affiliations

  • Published online on: March 4, 2016     https://doi.org/10.3892/br.2016.623
  • Pages: 623-627
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Abstract

In this randomized, double-blind, placebo controlled clinical trial, the effects of Dendropanax morbifera (D. morbifera) Léveille on heavy metal (cadmium and mercury) excretion as well as on lipid peroxidation and Cu, Zn-superoxide dismutase (SOD1) activity were investigated. For this study, tablets containing placebo or 300 mg of the leaf extract from D. morbifera Léveille were used. A total of 60 eligible healthy subjects were enrolled in this randomized, double‑blind, placebo‑controlled study. The differences in cadmium, mercury, and malondialdehyde (MDA) levels and SOD1 activity were measured in the serum 60 days after treatment with placebo or D. morbifera Léveille extracts. No significant differences between baseline characteristics and biochemical values were identified in subjects in the placebo and D. morbifera Léveille groups. Serum levels of cadmium, mercury and MDA decreased following consumption of D. morbifera Léveille extracts; however, no significant differences were identified. In addition, female, but not male, subjects who consumed D. morbifera Léveille extracts showed a significant increase in SOD1 activity. This result suggests that chronic consumption of D. morbifera Léveille extract can help to facilitate excretion of cadmium and mercury from serum and increase the antioxidant capacity in humans.
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May-2016
Volume 4 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Seo JS, Yoo DY, Jung HY, Kim DW, Hwang IK, Lee JY and Moon SM: Effects of Dendropanax morbifera Léveille extracts on cadmium and mercury secretion as well as oxidative capacity: A randomized, double-blind, placebo-controlled trial. Biomed Rep 4: 623-627, 2016
APA
Seo, J.S., Yoo, D.Y., Jung, H.Y., Kim, D., Hwang, I.K., Lee, J.Y., & Moon, S.M. (2016). Effects of Dendropanax morbifera Léveille extracts on cadmium and mercury secretion as well as oxidative capacity: A randomized, double-blind, placebo-controlled trial. Biomedical Reports, 4, 623-627. https://doi.org/10.3892/br.2016.623
MLA
Seo, J. S., Yoo, D. Y., Jung, H. Y., Kim, D., Hwang, I. K., Lee, J. Y., Moon, S. M."Effects of Dendropanax morbifera Léveille extracts on cadmium and mercury secretion as well as oxidative capacity: A randomized, double-blind, placebo-controlled trial". Biomedical Reports 4.5 (2016): 623-627.
Chicago
Seo, J. S., Yoo, D. Y., Jung, H. Y., Kim, D., Hwang, I. K., Lee, J. Y., Moon, S. M."Effects of Dendropanax morbifera Léveille extracts on cadmium and mercury secretion as well as oxidative capacity: A randomized, double-blind, placebo-controlled trial". Biomedical Reports 4, no. 5 (2016): 623-627. https://doi.org/10.3892/br.2016.623