Open Access

Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer

  • Authors:
    • Lin‑Feng Zheng
    • Wen‑Yong Sun
  • View Affiliations

  • Published online on: June 23, 2016     https://doi.org/10.3892/br.2016.705
  • Pages: 159-164
  • Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bladder cancer is the most common cancer of the urinary tract. A quarter of bladder cancer patients presenting with muscle‑invasive bladder cancer (MIBC) suffer significant morbidity and succumb to the disease. MicroRNA (miRNA) from tissue, urine or blood samples of MIBC patients have been demonstrated to differ from healthy individuals, and possibly have diagnostic value. The aim of the present meta‑analysis was to access the overall diagnostic accuracy comprehensively and quantitatively. Systematic searching in PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure database was conducted. The pooled sensitivity, specificity, positive and negative likelihood ratios (PLR and NLR) and diagnostic odds ratio (DOR) were calculated via the random effects model to evaluate the overall test performance. Deeks' funnel plot asymmetry test was used to test the publication bias. A total of 10 studies were included in the meta‑analysis, with a total of 577 patients and 412 controls. The pooled sensitivity and specificity were 0.78 [95% confidence interval (CI), 0.69‑0.86] and 0.77 (95% CI, 0.72‑0.81), respectively. The pooled PLR was 2.9 (95% CI, 2.1‑3.8), the NLR was 0.31 (95% CI, 0.27‑0.35), the DOR was 7 (95% CI, 4‑13) and the pooled AUC was 0.80 (95% CI, 0.69‑0.87). In conclusion, the current miRNA assays support their use as markers for MIBC diagnosis.
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August-2016
Volume 5 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Zheng LF and Sun WY: Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer. Biomed Rep 5: 159-164, 2016.
APA
Zheng, L., & Sun, W. (2016). Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer. Biomedical Reports, 5, 159-164. https://doi.org/10.3892/br.2016.705
MLA
Zheng, L., Sun, W."Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer". Biomedical Reports 5.2 (2016): 159-164.
Chicago
Zheng, L., Sun, W."Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer". Biomedical Reports 5, no. 2 (2016): 159-164. https://doi.org/10.3892/br.2016.705