Key proteins involved in insulin vesicle exocytosis and secretion (Review)

  • Authors:
    • Qian‑Yin Xiong
    • Cui Yu
    • Yao Zhang
    • Liefeng Ling
    • Lizhuo Wang
    • Jia‑Lin Gao
  • View Affiliations

  • Published online on: Tuesday, January 10, 2017
  • Pages:134-139 DOI: 10.3892/br.2017.839
0

Abstract

In vivo insulin secretion is predominantly affected by blood glucose concentration, blood concentration of amino acids, gastrointestinal hormones and free nerve functional status, in addition to other factors. Insulin is one of the most important hormones in the body, and its secretion is precisely controlled by nutrients, neurotransmitters and hormones. The insulin exocytosis process is similar to the neurotransmitter release mechanism. There are various types of proteins and lipids that participate in the insulin secretory vesicle fusion process, such as soluble N‑ethylmaleimide‑sensitive factor attachment protein receptor (SNARE) protein, Ras‑related proteins and vacuolar‑type H+‑ATPase (V‑ATPase). Notably, the SNARE protein is the molecular basis of exocytotic activity. In the current review, the role of the vesicle membrane proteins (synaptobrevins, vesicle associated membrane proteins and target membrane proteins) and auxiliary proteins (Rab proteins and Munc‑18 proteins) in vesicle fusion activity were summarized. A summary of these key proteins involved in insulin granule secretion will facilitate understanding of the pathogenesis of diabetes.

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February 2017
Volume 6 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
APA
Xiong, Q., Yu, C., Zhang, Y., Ling, L., Wang, L., & Gao, J. (2017). Key proteins involved in insulin vesicle exocytosis and secretion (Review). Biomedical Reports, 6, 134-139. http://dx.doi.org/10.3892/br.2017.839
MLA
Xiong, Q., Yu, C., Zhang, Y., Ling, L., Wang, L., Gao, J."Key proteins involved in insulin vesicle exocytosis and secretion (Review)". Biomedical Reports 6.2 (2017): 134-139.
Chicago
Xiong, Q., Yu, C., Zhang, Y., Ling, L., Wang, L., Gao, J."Key proteins involved in insulin vesicle exocytosis and secretion (Review)". Biomedical Reports 6, no. 2 (2017): 134-139. http://dx.doi.org/10.3892/br.2017.839