Animal models of atherosclerosis (Review)

Lee,Yee  Ting; Laxton,Victoria; Lin,Hiu  Yu; Chan,Yin  Wah Fiona; Fitzgerald‑Smith,Sophia; To,Tsz Ling Olivia; Yan,Bryan  P; Liu,Tong; Tse,Gary

doi:10.3892/br.2017.843

Animal models of atherosclerosis (Review)

Authors:
- Yee Ting Lee
- Victoria Laxton
- Hiu Yu Lin
- Yin Wah Fiona Chan
- Sophia Fitzgerald‑Smith
- Tsz Ling Olivia To
- Bryan P Yan
- Tong Liu
- Gary Tse
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Affiliations: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, P.R. China, Intensive Care Department, Royal Brompton and Harefield NHS Trust, London SW3 6NP, UK, School of Biological Sciences, University of Cambridge, Cambridge CB2 1AG, UK, Faculty of Medicine, University of Bristol, Bristol BS8 1TH, UK, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, P.R. China, Tianjin Key Laboratory of Ionic‑Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China
Published online on: January 17, 2017 https://doi.org/10.3892/br.2017.843
Pages: 259-266
Copyright : © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Atherosclerosis is a significant cause of morbidity and mortality globally. Many animal models have been developed to study atherosclerosis, and permit experimental conditions, diet and environmental risk factors to be carefully controlled. Pathophysiological changes can be produced using genetic or pharmacological means to study the harmful consequences of different interventions. Experiments using such models have elucidated its molecular and pathophysiological mechanisms, and provided platforms for pharmacological development. Different models have their own advantages and disadvantages, and can be used to answer different research questions. In the present review article, different species of atherosclerosis models are outlined, with discussions on the practicality of their use for experimentation.

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