Involvement of regucalcin gene promoter region-related protein-p117, a transcription factor, in human obesity (Review)

Yamaguchi,Masayoshi; Murata,Tomiyasu

doi:10.3892/br.2017.874

Involvement of regucalcin gene promoter region-related protein-p117, a transcription factor, in human obesity (Review)

Authors:
- Masayoshi Yamaguchi
- Tomiyasu Murata
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Affiliations: Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA, Laboratory of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, Nagoya, Aichi 468‑8503, Japan
Published online on: March 17, 2017 https://doi.org/10.3892/br.2017.874
Pages: 374-378

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Abstract

Regucalcin gene promoter region-related protein-p117 (RGPR-p117; gene symbol, rgpr-117) was identified in 2001 as a novel transcription factor that specifically binds to a nuclear factor I consensus motif, TTGGC(N)6CC in the promoter region of the regucalcin (rgn) gene. The human RGPR-p117 gene consists of 26 exons spanning ~4.1 kbp and is localized on chromosome 1q25.2. The nuclear translocation of cytoplasm RGPR‑p117 is mediated via the protein kinase C‑dependent signaling pathway. Overexpression of RGPR‑p117 enhances the transcription activity of rgn, and a protective effect on cell death by inhibition of gene expression levels of caspase‑3, caspase‑8 and FADD proteins that possess the TTGGC motif in the promoter region of those genes was revealed. RGPR‑p117 has a crucial role as a transcription factor. Notably, RGPR‑p117 was shown to localize in the plasma membranes, mitochondria and microsomes (endoplasmic reticulum; ER). RGPR‑p117, which is located in the ER, was also shown to have a role as an ER export factor implicated in the transports of proteins and lipids. As a result of this finding, it was proposed in 2007 that RGPR-p117 is renamed SEC 16 homolog B, endoplasmic reticulum export factor (SEC16B). Recently, there is increasing evidence that RGPR-p117/SEC16B may be involved in human obesity. Thus, the current review presents data regarding the involvement of RGPR-p117 in human obesity.

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