Use of dabigatran vs. warfarin with low‑molecular‑weight heparin bridging in catheter ablation for atrial fibrillation patients with a low CHADS2 score

  • Authors:
    • Li Hao
    • Bing Rong
    • Fei Xie
    • Ming‑Jie Lin
    • Jing‑Quan Zhong
  • View Affiliations

  • Published online on: March 28, 2017     https://doi.org/10.3892/br.2017.880
  • Pages: 549-554
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Abstract

The purpose of the present study was to compare the efficacy and safety of dabigatran and interrupted warfarin with low‑molecular‑weight heparin bridging in non‑valvular atrial fibrillation (AF) catheter ablation. Previously, there has been concerns that bridging therapy increases bleeding events without the benefit of stroke prevention. It has been suggested that bridging therapy should be considered only for patients at high‑risk of thrombosis. Nevertheless, bridging therapy in AF patients with a low CHADS2 score may be safe and effective.The authors performed a prospective, observational study that included consecutive 240 patients undergoing AF ablation in P.R. China. A total of 139 patients received 110 mg dabigatran twice daily and 101 patients took dose‑adjusted warfarin that had been bridged with low‑molecular‑weight heparin. The mean patient age was 55.48 years with 72.1% being men and 74.2% having paroxysmal AF. One thromboembolic complication occurred in the dabigatran group compared to none in the warfarin group. Both the groups presented a similar major bleeding rate, total bleeding rate, and bleeding and thromboembolic complications. In patients undergoing AF ablation, the risk of bleeding or thromboembolic complications was similar for both dabigatran and interrupted warfarin with bridging therapy. Bridging therapy appeared to be safe and effective for the low‑risk population.
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May-2017
Volume 6 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Hao L, Rong B, Xie F, Lin MJ and Zhong JQ: Use of dabigatran vs. warfarin with low‑molecular‑weight heparin bridging in catheter ablation for atrial fibrillation patients with a low CHADS2 score. Biomed Rep 6: 549-554, 2017.
APA
Hao, L., Rong, B., Xie, F., Lin, M., & Zhong, J. (2017). Use of dabigatran vs. warfarin with low‑molecular‑weight heparin bridging in catheter ablation for atrial fibrillation patients with a low CHADS2 score. Biomedical Reports, 6, 549-554. https://doi.org/10.3892/br.2017.880
MLA
Hao, L., Rong, B., Xie, F., Lin, M., Zhong, J."Use of dabigatran vs. warfarin with low‑molecular‑weight heparin bridging in catheter ablation for atrial fibrillation patients with a low CHADS2 score". Biomedical Reports 6.5 (2017): 549-554.
Chicago
Hao, L., Rong, B., Xie, F., Lin, M., Zhong, J."Use of dabigatran vs. warfarin with low‑molecular‑weight heparin bridging in catheter ablation for atrial fibrillation patients with a low CHADS2 score". Biomedical Reports 6, no. 5 (2017): 549-554. https://doi.org/10.3892/br.2017.880