Open Access

Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues (Review)

  • Authors:
    • Xiaolong Lin
    • Yuan Bo Liu
    • Huijun Hu
  • View Affiliations

  • Published online on: April 10, 2017     https://doi.org/10.3892/br.2017.890
  • Pages: 495-502
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The hepatokine fibroblast growth factor 21 (FGF21) is a novel polypeptide ligand, which is involved in glucose and lipid metabolism, and contributes significantly to lowering body weight and enhancing insulin sensitivity. A large number of pre‑clinical and clinical results demonstrate that FGF21 is a potential drug target for treating obesity and type 2 diabetes mellitus. In the present review, the tissue specific actions and molecular mechanisms of FGF21 are discussed with a focus on the liver, adipose tissue and nervous system, as well as investigating the outcomes of clinical trials of FGF21, with the aim of interpreting and delineating the complexity physiology of FGF21.
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May-2017
Volume 6 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Lin X, Liu YB and Hu H: Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues (Review). Biomed Rep 6: 495-502, 2017.
APA
Lin, X., Liu, Y.B., & Hu, H. (2017). Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues (Review). Biomedical Reports, 6, 495-502. https://doi.org/10.3892/br.2017.890
MLA
Lin, X., Liu, Y. B., Hu, H."Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues (Review)". Biomedical Reports 6.5 (2017): 495-502.
Chicago
Lin, X., Liu, Y. B., Hu, H."Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues (Review)". Biomedical Reports 6, no. 5 (2017): 495-502. https://doi.org/10.3892/br.2017.890