A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report

  • Authors:
    • Muhammad Asif
    • Abrar Hussain
    • Abdul Wali
    • Nazeer Ahmad
    • Naheed Sajjad
    • Muhammad Amir
    • Irfan Ali
    • Peter Natesan Pushparaj
    • Mahmood Rasool
  • View Affiliations

  • Published online on: August 17, 2017     https://doi.org/10.3892/br.2017.967
  • Pages: 377-379
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Abstract

Philadelphia (Ph)-positive chromosome or Ph translocation has been recognized in 90-95 chronic myeloid leukemia (CML) cases worldwide. However, only 5-8% CML patients show complex variant translocations. In the present study, hematological tests for a 47-year-old female CML patient were performed to determine the hemoglobin, platelets and total leukocyte values. A FISH test was carried out to recognize the BCR/ABL gene fusion, and a cytogenetic analysis was performed. The hematological results showed an increase in WBC (414000/mm3) and a decrease in hemoglobin (8.9 mg/dl), indicating the anemic condition in the CML patient. Furthermore, cytogenetic karyotyping results showed 46,XX,t(6;9;22)(p21;q34;q11) and positive for Ph chromosome. In conclusion, in the present study, we report a rare three-way complex variant translocation in a CML patient.
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October-2017
Volume 7 Issue 4

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Asif M, Hussain A, Wali A, Ahmad N, Sajjad N, Amir M, Ali I, Pushparaj PN and Rasool M: A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report. Biomed Rep 7: 377-379, 2017
APA
Asif, M., Hussain, A., Wali, A., Ahmad, N., Sajjad, N., Amir, M. ... Rasool, M. (2017). A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report. Biomedical Reports, 7, 377-379. https://doi.org/10.3892/br.2017.967
MLA
Asif, M., Hussain, A., Wali, A., Ahmad, N., Sajjad, N., Amir, M., Ali, I., Pushparaj, P. N., Rasool, M."A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report". Biomedical Reports 7.4 (2017): 377-379.
Chicago
Asif, M., Hussain, A., Wali, A., Ahmad, N., Sajjad, N., Amir, M., Ali, I., Pushparaj, P. N., Rasool, M."A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report". Biomedical Reports 7, no. 4 (2017): 377-379. https://doi.org/10.3892/br.2017.967