Fetal hepatocyte-derived culture medium elicits adipocyte differentiation to bile duct cell lineages in a mouse model

  • Authors:
    • Hisataka Ogawa
    • Masamitsu Konno
    • Koichi Kawamoto
    • Naohiro Nishida
    • Jun Koseki
    • Tsunekazu Mizushima
    • Taroh Satoh
    • Hidetoshi Eguchi
    • Yuichiro Doki
    • Masaki Mori
    • Hideshi Ishii
  • View Affiliations

  • Published online on: March 21, 2018     https://doi.org/10.3892/br.2018.1080
  • Pages: 497-499
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Abstract

Fetal cells in the developmental stages function with a distinct mechanism in comparison to adult tissues, which may be a useful source for regenerative medicine in postnatal medicine; however, the precise molecular mechanism remains to be elucidated fully. The present study investigated murine fetal hepatocytes, which were cultured in vitro, and the supernatants were used for the culture with murine adipose tissue‑derived cells. Notably, the results indicated that fetal hepatocyte‑derived culture medium elicits the induction of differentiation of adipose tissue‑derived cells to bile duct cell lineages, but not to hepatocyte lineages in mice. This indicates that fetal cells possess the multi potentials, which are already absent in adults, and may be useful for regenerative medicine in future.
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May-2018
Volume 8 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Ogawa H, Konno M, Kawamoto K, Nishida N, Koseki J, Mizushima T, Satoh T, Eguchi H, Doki Y, Mori M, Mori M, et al: Fetal hepatocyte-derived culture medium elicits adipocyte differentiation to bile duct cell lineages in a mouse model. Biomed Rep 8: 497-499, 2018.
APA
Ogawa, H., Konno, M., Kawamoto, K., Nishida, N., Koseki, J., Mizushima, T. ... Ishii, H. (2018). Fetal hepatocyte-derived culture medium elicits adipocyte differentiation to bile duct cell lineages in a mouse model. Biomedical Reports, 8, 497-499. https://doi.org/10.3892/br.2018.1080
MLA
Ogawa, H., Konno, M., Kawamoto, K., Nishida, N., Koseki, J., Mizushima, T., Satoh, T., Eguchi, H., Doki, Y., Mori, M., Ishii, H."Fetal hepatocyte-derived culture medium elicits adipocyte differentiation to bile duct cell lineages in a mouse model". Biomedical Reports 8.5 (2018): 497-499.
Chicago
Ogawa, H., Konno, M., Kawamoto, K., Nishida, N., Koseki, J., Mizushima, T., Satoh, T., Eguchi, H., Doki, Y., Mori, M., Ishii, H."Fetal hepatocyte-derived culture medium elicits adipocyte differentiation to bile duct cell lineages in a mouse model". Biomedical Reports 8, no. 5 (2018): 497-499. https://doi.org/10.3892/br.2018.1080