Importance of the Keap1-Nrf2 pathway in NSCLC: Is it a possible biomarker? (Review)

  • Authors:
    • Raúl Barrera-Rodríguez
  • View Affiliations

  • Published online on: September 5, 2018     https://doi.org/10.3892/br.2018.1143
  • Pages: 375-382
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Abstract

Worldwide, lung cancer remains the most common cause of cancer-related mortality, with non-small cell lung cancer (NSCLC) accounting for 85% of all diagnosed lung cancer cases. Chemotherapy is considered the standard of care for patients with advanced NSCLC; however, the tumors can develop mechanisms that inactivate these drugs. Comparative genomic analyses have revealed that disruptions in the kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid-2-related factor-2 (Nrf2) pathway are frequent in NSCLC, although Nrf2 mutations occur less frequently than Keap1 mutations. As the Keap1-Nrf2 pathway appears to be a primary regulator of key cellular processes that aid to resist the action of chemotherapy drugs, the clinical implementation of Nrf2 inhibitors in patients with advanced NSCLC may be a useful therapeutic approach for patients harboring KEAP1-NRF2 mutations. The aim of the present review was to highlight findings of how constitutive Nrf2 activation may be a specific biomarker for predicting patients most likely to benefit from classical chemotherapy drugs, overall improving patient survival rate.
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November-2018
Volume 9 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Barrera-Rodríguez R: Importance of the Keap1-Nrf2 pathway in NSCLC: Is it a possible biomarker? (Review). Biomed Rep 9: 375-382, 2018.
APA
Barrera-Rodríguez, R. (2018). Importance of the Keap1-Nrf2 pathway in NSCLC: Is it a possible biomarker? (Review). Biomedical Reports, 9, 375-382. https://doi.org/10.3892/br.2018.1143
MLA
Barrera-Rodríguez, R."Importance of the Keap1-Nrf2 pathway in NSCLC: Is it a possible biomarker? (Review)". Biomedical Reports 9.5 (2018): 375-382.
Chicago
Barrera-Rodríguez, R."Importance of the Keap1-Nrf2 pathway in NSCLC: Is it a possible biomarker? (Review)". Biomedical Reports 9, no. 5 (2018): 375-382. https://doi.org/10.3892/br.2018.1143