Open Access

Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)

  • Authors:
    • Juthamas Yosudjai
    • Sopit Wongkham
    • Siwanon Jirawatnotai
    • Worasak Kaewkong
  • View Affiliations

  • Published online on: January 25, 2019     https://doi.org/10.3892/br.2019.1188
  • Pages: 147-155
  • Copyright: © Yosudjai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cholangiocarcinoma is a lethal biliary cancer, with an unclear molecular pathogenesis. Alternative splicing is a post‑transcriptional modification that generates mature mRNAs, which are subsequently translated into proteins. Aberrant alternative splicing has been reported to serve a role in tumor initiation, maintenance and metastasis in several types of human cancer, including cholangiocarcinoma. In this review, the aberrant splicing of genes and the functional contributions of the spliced genes, in the carcinogenesis, progression and aggressiveness of cholangiocarcinoma are summarized. In addition, factors that influence this aberrant splicing that may be relevant as therapeutic targets or prognosis markers for cholangiocarcinoma are discussed.
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March-2019
Volume 10 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Yosudjai J, Wongkham S, Jirawatnotai S and Kaewkong W: Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review). Biomed Rep 10: 147-155, 2019.
APA
Yosudjai, J., Wongkham, S., Jirawatnotai, S., & Kaewkong, W. (2019). Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review). Biomedical Reports, 10, 147-155. https://doi.org/10.3892/br.2019.1188
MLA
Yosudjai, J., Wongkham, S., Jirawatnotai, S., Kaewkong, W."Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)". Biomedical Reports 10.3 (2019): 147-155.
Chicago
Yosudjai, J., Wongkham, S., Jirawatnotai, S., Kaewkong, W."Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)". Biomedical Reports 10, no. 3 (2019): 147-155. https://doi.org/10.3892/br.2019.1188