Hansen J, De Klerk NH, Eccles JL, Musk AW and Hobbs MS: Malignant mesothelioma after environmental exposure to blue asbestos. Int J Cancer. 54:578–581. 1993.PubMed/NCBI View Article : Google Scholar

Kanarek MS: Mesothelioma from chrysotile asbestos: Update. Ann Epidemiol. 21:688–697. 2011.PubMed/NCBI View Article : Google Scholar

Bayram M, Dongel I, Bakan ND, Yalççn H, Cevit R, Dumortier P and Nemery B: High risk of malignant mesothelioma and pleural plaques in subjects born close to ophiolites. Chest. 143:164–171. 2013.PubMed/NCBI View Article : Google Scholar

Carbone M, Kanodia S, Chao A, Miller A, Wali A, Weissman D, Adjei A, Baumann F, Boffetta P, Buck B, et al: Consensus report of the 2015 weinman international conference on mesothelioma. J Thorac Oncol. 11:1246–1262. 2016.PubMed/NCBI View Article : Google Scholar

Case BW, Abraham JL, Meeker G, Pooley FD and Pinkerton KE: Applying definitions of ‘asbestos’ to environmental and ‘low-dose’ exposure levels and health effects, particularly malignant mesothelioma. J Toxicol Environ Health B Crit Rev. 14:3–39. 2011.PubMed/NCBI View Article : Google Scholar

Huang SX, Jaurand MC, Kamp DW, Whysner J and Hei TK: Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases. J Toxicol Environ Health B Crit Rev. 14:179–245. 2011.PubMed/NCBI View Article : Google Scholar

Liu G, Cheresh P and Kamp DW: Molecular basis of asbestos-induced lung disease. Annu Rev Pathol. 8:161–187. 2013.PubMed/NCBI View Article : Google Scholar

Ledda C, Pomara C, Bracci M, Mangano D, Ricceri V, Musumeci A, Ferrante M, Musumeci G, Loreto C, Fenga C, et al: Natural carcinogenic fiber and pleural plaques assessment in a general population: A cross-sectional study. Environ Res. 150:23–29. 2016.PubMed/NCBI View Article : Google Scholar

Falzone L, Marconi A, Loreto C, Franco S, Spandidos DA and Libra M: Occupational exposure to carcinogens: Benzene, pesticides and fibers (Review). Mol Med Rep. 14:4467–4474. 2016.PubMed/NCBI View Article : Google Scholar

Gangemi S, Rapisarda V, Minciullo PL, Di Pasquale G, Lombardo G, Valentino M and Fenga C: Circulating levels of interleukin-18 in asbestos-exposed workers. Toxicol Ind Health. 21:125–129. 2005.

Aitio A, Cantor KP, Attfield MD, Demers PA, Fowler BA, Grandjean P, Fubini B, Hartwig A, Gérin M, et al: A review of human carcinogens: Arsenic, metals, fibres and dusts. Vol 100 C. IARC, Lyon, pp219-224, 2012.

Travaglione S, Bruni B, Falzano I, Paoletti I and Fiorentini C: Effects of the new-identified amphibole FE in lung epithelial cells. Toxicol In Vitro. 17:547–552. 2003.

Pikarsky E, Porat RM, Stein I, Abramovitch R, Admit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E and Ben-Neriah Y: NF-kappaB function as a tumor promoter in inflammation-associated cancer. Nature. 431:461–466. 2004.PubMed/NCBI View Article : Google Scholar

Tokokuni S: Mechanisms of asbestos-induced carcinogenesis. Nagoya J Med Sci. 71:1–10. 2009.PubMed/NCBI

Koskinen K, Rinne JP, Zitting A, Tossavainen A, Kivekäs J, Reijula K, Roto P and Huuskonen MS: Screening for asbestos-induced diseases in Finland. Am J Ind Med. 30:241–251. 1996.PubMed/NCBI View Article : Google Scholar

Pan XL, Day HW, Wang W, Beckett LA and Schenker MB: Residential proximity to naturally occurring asbestos and mesothelioma risk in California. Am J Respir Crit Care Med. 172:1019–1025. 2005.PubMed/NCBI View Article : Google Scholar

Luo S, Liu X, Mu S, Tsai SP and Wen CP: Asbestos related diseases from environmental exposure to crocidolite in Da-yao, China. I. Review of exposure and epidemiological data. Occup Environ Med. 60:35–41. 2003.PubMed/NCBI View Article : Google Scholar

Baumann F, Maurizot P, Mangeas M, Ambrosi JP, Douwes J and Robineau B: Pleural mesothelioma in New Caledonia: Associations with environmental risk factors. Environ Health Perspect. 119:695–700. 2011.PubMed/NCBI View Article : Google Scholar

Rey F, Boutin C, Steinbauer J, Viallat JR, Alessandroni P, Jutisz P, Di Giambattista D, Billon-Galland MA, Hereng P, Dumortier P, et al: Environmental pleural plaques in an asbestos exposed population of northeast Corsica. Eur Respir J. 6:978–982. 1993.PubMed/NCBI

McConnochie K, Simonato L, Mavrides P, Christofides P, Pooley FD and Wagner JC: Mesothelioma in Cyprus: The role of tremolite. Thorax. 42:342–347. 1987.PubMed/NCBI View Article : Google Scholar

Constantopoulos SH: Environmental mesothelioma associated with tremolite asbestos: Lessons from the experiences of Turkey, Greece, Corsica, New Caledonia and Cyprus. Regul Toxicol Pharmacol. 52 (1 Suppl):S110–S115. 2008.PubMed/NCBI View Article : Google Scholar

Baris YI, Artvinli M, Sahin AA, Sebastien P and Gaudichet A: Diffuse lung fibrosis due fibrous zeolite (erionite) exposure. Eur J Respir Dis. 70:122–125. 1987.PubMed/NCBI

Yazicioglu S, Ilçayto R, Balci K, Sayli BS and Yorulmaz B: Pļeural calcification, pleural mesotheliomas, and bronchial cancers caused by tremolite dust. Thorax. 35:564–569. 1980.PubMed/NCBI View Article : Google Scholar

Dumortier P, Coplü L, de Maertelaer V, Emri S, Baris I and De Vuyst P: Assessment of environmental asbestos exposure in Turkey by bronchoalveolar lavage. Am J Respir Crit Care Med. 158:1815–1824. 1998.PubMed/NCBI View Article : Google Scholar

Senyigit A, Dalgic A, Kavak O and Tanrikulu AC: Determination of environmental exposure to asbestos (tremolite) and mesothelioma risks in the southeastern region of Turkey. Arch Environ Health. 59:658–662. 2004.PubMed/NCBI View Article : Google Scholar

Metintas M, Metintas S, Hillerdal G, Ucgun I, Erginel S, Alatas F and Yildirim H: Non malignant pleural lesions due to environmental exposure to asbestos: A field-based, cross-sectional study. Eur Respir J. 26:875–880. 2005.PubMed/NCBI View Article : Google Scholar

Döngel I, Bayram M, Bakan ND, Yalçın H and Gültürk S: Is living close to ophiolites related to asbestos related diseases? Cross-sectional study. Respir Med. 107:870–874. 2013.PubMed/NCBI View Article : Google Scholar

Kliment CR, Clemens K and Oury TD: North American erionite-associated mesothelioma with pleural plaques and pulmonary fibrosis: A case report. Int J Clin Exp Pathol. 2:407–410. 2009.PubMed/NCBI

Baumann F, Buck BJ, Metcalf RV, McLaurin BT, Merkler DJ and Carbone M: The presence of asbestos in the natural environment is likely related to mesothelioma in young individuals and women from southern Nevada. J Thorac Oncol. 10:731–737. 2015.PubMed/NCBI View Article : Google Scholar

Konen T, Johnson JE, Lindgren P and Williams A: Cancer incidence and mortality associated with non-occupational and low dose exposure to Libby vermiculite in Minnesota. Environ Res. 175:449–456. 2019.PubMed/NCBI View Article : Google Scholar

Baur X: Review on the adverse health effects of asbestiform antigorite, a non-regulated asbestiform serpentine mineral. Am J Ind Med. 61:625–630. 2018.PubMed/NCBI View Article : Google Scholar

Cardile V, Lombardo L, Belluso E, Panico A, Capella S and Balazy M: Toxicity and carcinogenicity mechanisms of fibrous antigorite. Int J Environ Res Public Health. 4:1–9. 2007.PubMed/NCBI View Article : Google Scholar

Groppo C and Compagnoni R: Ubiquitous fibrous antigorite veins from the Lanzo Ultramafic Massif, Internal Western Alps (Italy): Characterisation and genetic conditions. Per Mineral. 76:169–181. 2007.

FitzGerald J, Eggleton R and Keeling J: Antigorite from Rowland flat, South Australia: Asbestiform character. Eur J Mineral. 22:525–533. 2010.

Fitzgerald SM and Harty EA: Antigorite: Is it the forgotten asbestos? Prof Saf. 59:43–48. 2014.

Soffritti M, Minardi F, Bua L, Degli Esposti D and Belpoggi F: First experimental evidence of peritoneal and pleural mesotheliomas induced by FE fibres present in Etnean volcanic material from Biancavilla (Sicily, Italy). Eur J Oncol. 9:169–715. 2004.

Gianfagna A and Oberti R: Fluoro-edenite from Biancavilla (Catania, Sicily, Italy): Crystal chemistry of a new amphibole end-member. Am Mineral. 86:1489–1493. 2001.

Biggeri A, Pasetto R, Belli S, Bruno C, Di Maria G, Mastrantonio M, Trinca S, Uccelli R and Comba P: Mortality from chronic obstructive pulmonary disease and pleural mesothelioma in an area contaminated by natural fiber (fluoro-edenite). Scand J Work Environ Health. 30:249–252. 2004.PubMed/NCBI View Article : Google Scholar

Comba P, Gianfagna A and Paoletti L: Pleural mesothelioma cases in Biancavilla are related to a new fluoro-edenite fibrous amphibole. Arch Environ Health. 58:229–232. 2003.PubMed/NCBI View Article : Google Scholar

Gianfagna A, Ballirano P, Bellatreccia F, Bruni B, Paoletti L and Oberti R: Characterization of amphibole fibres linked to mesothelioma in the area of Biancavilla, Eastern Sicily, Italy. Mineral Mag. 67:1221–1229. 2003.

Ledda C, Costa C, Matera S, Puglisi B, Costanzo V, Bracci M, Fenga C, Rapisarda V and Loreto C: Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers. Mol Med Rep. 15:3372–3378. 2017.PubMed/NCBI View Article : Google Scholar

Ledda C and Rapisarda V: Malignant pleural mesothelioma: The need to move from research to clinical practice. Arch Med Res. 47(407)2016.PubMed/NCBI View Article : Google Scholar

Martinez G, Loreto C, Rapisarda V, Musumeci G, Valentino M and Carnazza ML: Effects of exposure to fluoro-edenite fibre pollution on the respiratory system: An in vivo model. Histol Histopathol. 21:595–601. 2006.PubMed/NCBI View Article : Google Scholar

Caltabiano R, Loreto C, Vitale E, Matera S, Miozzi E, Migliore M, Angelico G, Tumino R, Ledda C and Rapisarda V: Fibulin-3 immunoexpression in malignant mesothelioma due to fluoro-edenite: A preliminary report. Future Oncol. 14 (6 Suppl):S53–S57. 2018.PubMed/NCBI View Article : Google Scholar

Paoletti L, Batisti D, Bruno C, Di Paola M, Gianfagna A, Mastrantonio M, Nesti M and Comba P: Unusually high incidence of malignant pleural mesothelioma in a town of eastern Sicily: An epidemiological and environmental study. Arch Environ Health. 55:392–398. 2000.PubMed/NCBI View Article : Google Scholar

Di Paola M, Mastrantonio M, Carboni M, Belli S, Grignoli M, Comba P and Nesti M: Mortality from malignant pleural neoplasms in Italy in the years 1988-1992. Rapporti ISTISAN, 96/40. Istituto Superiore di Sanità, Rome, 1996.

Fazzo L, De Santis M, Minelli G, Bruno C, Zona A, Marinaccio A, Conti S and Comba P: Pleural mesothelioma mortality and asbestos exposure mapping in Italy. Am J Industr Med. 55:11–24. 2012.PubMed/NCBI View Article : Google Scholar

Fazzo L, Minelli G, De Santis M, Bruno C, Zona A, Marinaccio A, Conti S, Pirastu R and Comba P: Mesothelioma mortality surveillance and asbestos exposure tracking in Italy. Ann Ist Super Sanita. 48:300–310. 2012.PubMed/NCBI View Article : Google Scholar

Rapisarda V, Ledda C, Ricceri V, Arena F, Musumeci A, Marconi A, Fago L, Bracci M, Santarelli L and Ferrante M: Detection of pleural plaques in workers exposed to inhalation of natural fluoro-edenite fibres. Oncol Lett. 9:2046–2052. 2015.PubMed/NCBI View Article : Google Scholar

Ledda C, Loreto C, Matera S, Massimino N, Cannizzaro E, Musumeci A, Migliore M, Fenga C, Pomara C and Rapisarda V: Early effects of fluoro-edenite: Correlation between IL-18 serum levels and pleural and parenchymal abnormalities. Future Oncol. 12 (23 Suppl):S59–S62. 2016.PubMed/NCBI View Article : Google Scholar

Grosse Y, Loomis D, Guyton KZ, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Scoccianti C, Mattock H and Straif K: Carcinogenicity of fluoro-edenite, silicon carbide fibres and whiskers, and carbon nanotubes. Lancet Oncol. 15:1427–1428. 2014.PubMed/NCBI View Article : Google Scholar

Miller SA: PICO worksheet and search strategy. National Center for Dental Hygiene Research, 2001.

Fenoglio I, Croce A, Di Renzo F, Tiozzo R and Fubini B: Pure-silica zeolites (Porosils) as model solids for the evaluation of the physicochemical features determining silica toxicity to macrophages. Chem Res Toxicol. 13:489–500. 2000.PubMed/NCBI View Article : Google Scholar

Pugnaloni A, Lucarini G, Giantomassi F, Lombardo L, Capella S, Belluso E, Zizzi A, Panico AM, Biagini G and Cardile V: In vitro study of biofunctional indicators after exposure to asbestos-like fluoro-edenite fibres. Cell Mol Biol (Noisy-le-grand). 53 (Suppl):OL965–OL980. 2007.PubMed/NCBI

Tremblay GM, Jordana M, Gauldie J and Särnstrand B: Fibroblasts as effector cells in fibrosis. In: Pulmonary fibrosis. Phan SH and Thrall RS (eds). Marcel Dekker Inc., New York, NY, pp541-577, 1995.

Travaglione S, Bruni BM, Falzano L, Filippini P, Fabbri A, Paoletti L and Fiorentini C: Multinucleation and pro-inflammatory cytokine release promoted by fibrous fluoro-edenite in lung epithelial A549 cells. Toxicol in Vitro. 20:841–850. 2006.PubMed/NCBI View Article : Google Scholar

Li XY, Lamb D and Donaldson K: The production of TNF-alpha and IL-1-like activity by bronchoalveolar leucocytes after intratracheal instillation of crocidolite asbestos. Int J Exp Pathol. 74:403–410. 1993.PubMed/NCBI

Trimblin C, BeruBe K, Churg A, Driscoll K, Gordon T, Hemenway D, Walsh E, Cummins AB, Vacek P and Mossman B: Ambient particulate matter causes activation of the c-jun kinase/stress-activated protein kinase cascade and DNA synthesis in lung epithelial cells. Cancer Res. 58:4543–4547. 1998.PubMed/NCBI

Hedges S, Svensson M, Agace W and Svanborg C: Cytokines induce an epithelial cell cytokine response. Adv Exp Med Biol. 371A:189–193. 1995.PubMed/NCBI View Article : Google Scholar

Cardile V, Proietti L, Panico A and Lombardo L: Nitric oxide production in fluoro-edenite treated mouse monocyte-macrophage cultures. Oncol Rep. 12:1209–1215. 2004.PubMed/NCBI

Hedenborg M and Klockars M: Production of reactive oxygen metabolites induced by asbestos fibres in human polymorphonuclear leucocytes. J Clin Pathol. 40:1189–1193. 1987.PubMed/NCBI View Article : Google Scholar

Hamilton RF, Iyer LL and Holian A: Asbestos induces apoptosis in human alveolar macrophages. Am J Physiol. 271:L813–L819. 1996.PubMed/NCBI View Article : Google Scholar

Loreto C, Carnazza ML, Cardile V, Libra M, Lombardo L, Malaponte G, Martinez G, Musumeci G, Papa V and Cocco L: Mineral fiber-mediated activation of phosphoinositide-specific phospholipase c in human bronchoalveolar carcinoma-derived alveolar epithelial A549 cells. Int J Oncol. 34:371–376. 2009.PubMed/NCBI

Cardile V, Renis M, Scifo C, Lombardo L, Gulino R, Mancari B and Panico A: Behaviour of the new asbestos amphibole fluor-edenite in different lung cell systems. Int J Biochem Cell Biol. 36:849–860. 2004.PubMed/NCBI View Article : Google Scholar

Pӓӓkkӧ P, Rämet M, Vähäkangas K, Korpela N, Soini Y, Turunen S, Jaworska M and Gillissen A: Crocidolite asbestos causes an induction of p53 and apoptosis in cultured A-549 lung carcinoma cells. Apoptosis. 3:203–212. 1998.PubMed/NCBI View Article : Google Scholar

Yang CM, Luo SF, Wang CC, Chiu CT, Chien CS, Lin CC and Hsiao LD: Tumour necrosis factor-alpha- and interleukin-1beta-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells. Br J Pharmac. 130:891–899. 2000.PubMed/NCBI View Article : Google Scholar

Rana Rs and Hokin LE: Role of phosphoinositides in trans-membrane signaling. Physiol Rev. 70:115–164. 1990.PubMed/NCBI View Article : Google Scholar

Lim Y, Kim SH, Kim KA, Oh MW and Lee KH: Involvement of protein kinase C, phospholipase C, and protein tyrosine kinase pathways in oxygen radical generation by asbestos-stimulated alveolar macrophage. Environ Health Perspect. 105 (Suppl 5):S1325–S1327. 1997.PubMed/NCBI View Article : Google Scholar

Musumeci G, Cardile V, Fenga C, Caggia S and Loreto C: Mineral fibre toxicity: Expression of retinoblastoma (Rb) and phospho-retinoblastoma (pRb) protein in alveolar epithelial and mesothelial cell lines exposed to fluoro-edenite fibres. Cell Biol Toxicol. 27:217–225. 2011.PubMed/NCBI View Article : Google Scholar

Beachy PA, Karhadkar SS and Berman DM: Tissue repair and stem cell renewal in carcinogenesis. Nature. 432:324–331. 2004.PubMed/NCBI View Article : Google Scholar

Chen S, Guttrige DC, You Z, Zhang Z, Fribley A, Mayo MW, Kitajewski J and Wang CY: Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol. 152:87–96. 2001.PubMed/NCBI View Article : Google Scholar

Zheng R, Yano S, Matsumori Y, Nakataki E, Muguruma H, Yoshizumi M and Sone S: SRC tyrosine kinase inhibitor, m475271, suppresses subcutaneous growth and production of lung metastasis via inhibition of proliferation, invasion, and vascularization of human lung adenocarcinoma cells. Clin Exp Metastasis. 22:195–204. 2005.PubMed/NCBI View Article : Google Scholar

Yamanouchi H, Furihata M, Fujita JJ, Murakami H, Yoshinouchi T, Takahara J and Ohtsuki Y: Expression of cyclin E and cyclin D1 in non-small cell lung cancers. Lung Cancer. 31:3–8. 2001.PubMed/NCBI View Article : Google Scholar

Rapisarda V, Salemi R, Marconi A, Loreto C, Graziano AC, Cardile V, Basile MS, Candido S, Falzone L, Spandidos DA, et al: Fluoro-edenite induces fibulin-3 overexpression in non-malignant human mesothelial cells. Oncol Lett. 12:3363–3367. 2016.PubMed/NCBI View Article : Google Scholar

Chu IM, Hengst L and Slingerland JM: The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy. Nat Rev Cancer. 8:253–267. 2008.PubMed/NCBI View Article : Google Scholar

Rapisarda V, Caltabiano R, Musumeci G, Castrogiovanni P, Ferrante M, Ledda C, Lombardo C, Graziano ACE, Cardile V and Loreto C: Analysis of fibulin-3 after exposure to asbestos-like fibers. Environ Res. 156:381–387. 2017.PubMed/NCBI View Article : Google Scholar

Filetti V, Falzone L, Rapisarda V, Caltabiano R, Graziano ACE, Ledda C and Loreto C: Modulation of microRNA expression levels after naturally occurring asbestiform fibers exposure as a diagnostic biomarker of mesothelial neoplastic transformation. Ecotoxicol Environ Saf. 198(110640)2020.PubMed/NCBI View Article : Google Scholar

Cardile V, Lombardo L, Belluso E, Panico A, Renis M, Gianfagna A and Balazy M: Fluoro-edenite fibers induce expression of Hsp70 and inflammatory response. Int J Environ Res Public Health. 4:195–202. 2007.PubMed/NCBI View Article : Google Scholar

Shukla A, Gulumian M, Hei TK, Kamp D, Rahman Q and Mossman B: Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases. Free radical Biol Med. 34:1117–1129. 2003.PubMed/NCBI View Article : Google Scholar

Holian A, Kelley K and Hamilton RF Jr: Mechanisms associated with human alveolar macrophage stimulation by particulates. Environ Health Perspect. 102 (Suppl 10):S69–S74. 1994.PubMed/NCBI View Article : Google Scholar

De Witt DL: Prostaglandin endoperoxide synthase: Regulation of enzyme expression. Biochim Byophys Acta. 1083:121–134. 1991.PubMed/NCBI View Article : Google Scholar

DeNardo P, Bruni B, Paoletti L, Pasetto R and Sirianni B: Pulmonary fibre burden in sheep living in the Biancavilla area (Sicily): Preliminary results. Sci Total Environ. 325:51–58. 2004.PubMed/NCBI View Article : Google Scholar

Loreto C, Rapisarda V, Carnazza ML, Musumeci G, Valentino M, Fenga C and Martinez G: Fluoro-edenite fibres induce lung cell apoptosis: An in vivo study. Histol Histopathol. 23:319–326. 2008.PubMed/NCBI View Article : Google Scholar

Musumeci G, Loreto C, Cardile V, Carnazza ML and Martinez G: Immunohistochemical expression of retinoblastoma and phospho-retinoblastoma protein in sheep lung exposed to fluoro-edenite fibers. Anat Sci Int. 85:74–78. 2010.PubMed/NCBI View Article : Google Scholar

Musumeci G, Loreto C, Giunta S, Rapisarda V, Szychlinska MA, Imbesi R, Castorina A, Annese T, Castorina S, Castrogiovanni P and Ribatti D: Angiogenesis correlates with macrophage and mast cell infiltration in lung tissue of animals exposed to fluoro-edenite fibers. Exp Cell Res. 346:91–98. 2016.PubMed/NCBI View Article : Google Scholar

Loreto C, Lombardo C, Caltabiano R, Ledda C, Hagnas M, Filetti V and Rapisarda V: An in vivo immunohistochemical study on MacroH2A.1 in lung and lymph-node tissues exposed to an asbestiform fiber. Curr Mol Med: Feb 20, 2020 (Epub ahead of print).

Ledda C, Loreto C, Pomara C, Rapisarda G, Fiore M, Ferrante M, Bracci M, Santarelli L, Fenga C and Venerando R: Sheep lymph-nodes as a biological indicator of environmental exposure to fluoro-edenite. Environ Res. 147:97–101. 2016.PubMed/NCBI View Article : Google Scholar

Belpoggi F, Tibaldi E, Lauriola M, Bua L, Falcioni L, Chiozzotto D, Manservisi F, Manservigi M and Soffritti M: The efficacy of long-term bioassays in predicting human risks: Mesotheliomas induced by fluoro-edenite fibres present in lava stone from the Etna volcano in Biancavilla, Italy. Eur J Oncol. 16:185–196. 2011.

Begin R, Rola-Pleszczynski M, Sirois P, Masse S, Nadeau D and Bureau MA: Sequential analysis of the bronchoalveolar milieu in conscious sheep. J Appl Physiol Resp Envir Exerc Physiol. 50:665–671. 1981.PubMed/NCBI View Article : Google Scholar

Schlesinger RB: Clearance from the respiratory tract. Fundam Appl Toxicol. 5:435–450. 1985.PubMed/NCBI View Article : Google Scholar

Dumortier P, Rey F, Viallat JR, Broucke I, Boutin C and De Vuyst P: Chrysotile and tremolite asbestos fibres in the lungs and parietal pleura of Corsican goats. Occup Env Med. 59:643–646. 2002.PubMed/NCBI View Article : Google Scholar

Musumeci G, Loreto C, Szychlinska MA, Imbesi R, Rapisarda V, Aiello FC, Castorina S and Castrogiovanni P: N-Cadherin, ADAM-10 and Aquaporin 1 expression in lung tissue exposed to fluoro-edenite fibers: An immunohistochemical study. Histol Histopathol. 30:987–999. 2015.PubMed/NCBI View Article : Google Scholar

Rapisarda V, Rapisarda G, Vico CD, Gobbi L, Loreto C and Valentino M: Monitoring of fluoro-edenite fibre pollution through the study of sheep lymph nodes as a model of a biological indicator. Occup Environ Med. 62(656)2005.PubMed/NCBI View Article : Google Scholar

Angelico G, Caltabiano R, Loreto C, Ieni A, Tuccari G, Ledda C and Rapisarda V: Immunohistochemical expression of aquaporin-1 in fluoro-edenite-induced malignant mesothelioma: A preliminary report. Int J Mol Sci. 19(685)2018.PubMed/NCBI View Article : Google Scholar

Ledda C, Caltabiano R, Loreto C, Cinà D, Senia P, Musumeci A, Ricceri V, Pomara C and Rapisarda V: Prevalence of anti-nuclear autoantibodies in subjects exposed to natural asbestiform fibers: A cross-sectional study. J Immunotoxicol. 15:24–28. 2018.PubMed/NCBI View Article : Google Scholar

Rapisarda V, Loreto C, Castorina S, Romano G, Garozzo SF, Musumeci A, Migliore M, Avola R, Cinà D, Pomara C and Ledda C: Occupational exposure to fluoro-edenite and prevalence of anti-nuclear autoantibodies. Future Oncol. 14 (6 Suppl):S59–S62. 2018.PubMed/NCBI View Article : Google Scholar

Baas P, Fennell D, Kerr KM, van Schil PE, Haas RL and Peters S: ESMO Guidelines Committee. Malignant pleural mesothelioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 26 (Suppl 5):v31–v39. 2015.PubMed/NCBI View Article : Google Scholar

Ying S, Jiang Z, He X, Yu M, Chen R, Chen J, Ru G, Chen Y, Chen W, Zhu L, et al: Serum HMGB1 as a potential biomarker for patients with asbestos-related diseases. Dis Markers. 2017(5756102)2017.PubMed/NCBI View Article : Google Scholar

Tomasson K, Gudmundsson G, Briem H and Rafnsson V: Malignant mesothelioma incidence by nation-wide cancer registry: A population-based study. J Occup Med Toxicol. 11(37)2016.PubMed/NCBI View Article : Google Scholar

Cui A, Jin XG, Zhai K, Tong ZH and Shi HZ: Diagnostic values of soluble mesothelin-related peptides for malignant pleural mesothelioma: Updated meta-analysis. BMJ Open. 4(e004145)2014.PubMed/NCBI View Article : Google Scholar

Arnold DT and Maskell NA: Biomarkers in mesothelioma. Ann Clin Biochem. 55:49–58. 2018.PubMed/NCBI View Article : Google Scholar

Wu T, Zhang W, Yang G, Li H, Chen Q, Song R and Zhao L: HMGB1 overexpression as a prognostic factor for survival in cancer: A meta-analysis and systematic review. Oncotarget. 7:50417–50427. 2016.PubMed/NCBI View Article : Google Scholar

Creaney J, Sneddon S, Dick IM, Dare H, Boudville N, Musk AW, Skates SJ and Robinson BW: Comparison of the diagnostic accuracy of the MSLN gene products, mesothelin and megakaryocyte potentiating factor, as biomarkers for mesothelioma in pleural effusions and serum. Dis Markers. 35:119–127. 2013.PubMed/NCBI View Article : Google Scholar

Creaney J, Dick IM, Meniawy TM, Leong SL, Leon JS, Demelker Y, Segal A, Musk AW, Lee YC, Skates SJ, et al: Comparison of fibulin-3 and mesothelin as markers in malignant mesothelioma. Thorax. 69:895–902. 2014.PubMed/NCBI View Article : Google Scholar

Chen Z, Gaudino G, Pass HI, Carbone M and Yang H: Diagnostic and prognostic biomarkers for malignant mesothelioma: An update. Transl Lung Cancer Res. 6:259–269. 2017.PubMed/NCBI View Article : Google Scholar

Boudville N, Paul R, Robinson BW and Creaney J: Mesothelin and kidney function-analysis of relationship and implications for mesothelioma screening. Lung Cancer. 73:320–324. 2011.PubMed/NCBI View Article : Google Scholar

Lim CB, Prêle CM, Cheah HM, Cheng YY, Klebe S, Reid G, Watkins DN, Baltic S, Thompson PJ and Mutsaers SE: Mutational analysis of hedgehog signaling pathway genes in human malignant mesothelioma. PLoS One. 8(e66685)2013.PubMed/NCBI View Article : Google Scholar

Shi Y, Moura U, Opitz I, Soltermann A, Rehrauer H, Thies S, Weder W, Stahel RA and Felley-Bosco E: Role of hedgehog signaling in malignant pleural mesothelioma. Clin Cancer Res. 18:4646–4656. 2012.PubMed/NCBI View Article : Google Scholar

Candido S, Lupo G, Pennisi M, Basile MS, Anfuso CD, Petralia MC, Gattuso G, Vivarelli S, Spandidos DA, Libra M and Falzone L: The analysis of miRNA expression profiling datasets reveals inverse microRNA patterns in glioblastoma and Alzheimer's disease. Oncol Rep. 42:911–922. 2019.PubMed/NCBI View Article : Google Scholar

Falzone L, Romano GL, Salemi R, Bucolo C, Tomasello B, Lupo G, Anfuso CD, Spandidos DA, Libra M and Candido S: Prognostic significance of deregulated microRNAs in uveal melanomas. Mol Med Rep. 19:2599–2610. 2019.PubMed/NCBI View Article : Google Scholar

Nikolouzakis TK, Vassilopoulou L, Fragkiadaki P, Mariolis Sapsakos T, Papadakis GZ, Spandidos DA, Tsatsakis AM and Tsiaoussis J: Improving diagnosis, prognosis and prediction by using biomarkers in CRC patients (Review). Oncol Rep. 39:2455–2472. 2018.PubMed/NCBI View Article : Google Scholar

Ledda C, Senia P and Rapisarda V: Biomarkers for early diagnosis and prognosis of malignant pleural mesothelioma: The quest goes on. Cancers (Basel). 10(203)2018.PubMed/NCBI View Article : Google Scholar

De Santi C, Melaiu O, Bonotti A, Cascione L, Di Leva G, Foddis R, Cristaudo A, Lucchi M, Mora M, Truini A, et al: Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism. Sci Rep. 7(3140)2017.PubMed/NCBI View Article : Google Scholar

Martínez-Rivera V, Negrete-García MC, Ávila-Moreno F and Ortiz-Quintero B: Secreted and tissue miRNAs as diagnosis biomarkers of malignant pleural mesothelioma. Int J Mol Sci. 19(595)2018.PubMed/NCBI View Article : Google Scholar

Falzone L, Candido S, Salemi R, Basile MS, Scalisi A, McCubrey JA, Torino F, Signorelli SS and Montella M: Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer. Oncotarget. 7:72758–72766. 2016.PubMed/NCBI View Article : Google Scholar

Falzone L, Scola L, Zanghì A, Biondi A, Di Cataldo A, Libra M and Candido S: Integrated analysis of colorectal cancer microRNA datasets: Identification of microRNAs associated with tumor development. Aging (Albany NY). 10:1000–1014. 2018.PubMed/NCBI View Article : Google Scholar

Hafsi S, Candido S, Maestro R, Falzone L, Soua Z, Bonavida B, Spandidos DA and Libra M: Correlation between the overexpression of Yin Yang 1 and the expression levels of miRNAs in Burkitt's lymphoma: A computational study. Oncol Lett. 11:1021–1025. 2016.PubMed/NCBI View Article : Google Scholar

Polo A, Crispo A, Cerino P, Falzone L, Candido S, Giudice A, De Petro G, Ciliberto G, Montella M, Budillon A and Costantini S: Environment and bladder cancer: Molecular analysis by interaction networks. Oncotarget. 8:65240–65252. 2017.PubMed/NCBI View Article : Google Scholar

Salemi R, Falzone L, Madonna G, Polesel J, Cinà D, Mallardo D, Ascierto PA, Libra M and Candido S: MMP-9 as a candidate marker of response to BRAF inhibitors in melanoma patients with BRAF^V600E mutation detected in circulating-free DNA. Front Pharmacol. 9(856)2018.PubMed/NCBI View Article : Google Scholar

Cavallari I, Urso L, Sharova E, Pasello G and Ciminale V: Liquid biopsy in malignant pleural mesothelioma: State of the art, pitfalls, and perspectives. Front Oncol. 9(740)2019.PubMed/NCBI View Article : Google Scholar

Tuaeva NO, Falzone L, Porozov YB, Nosyrev AE, Trukhan VM, Kovatsi L, Spandidos DA, Drakoulis N, Kalogeraki A, Mamoulakis C, et al: Translational application of circulating DNA in oncology: Review of the last decades achievements. Cells. 8(1251)2019.PubMed/NCBI View Article : Google Scholar