Short‑term efficacy after switching from adefovir dipivoxil and tenofovir disoproxil fumarate therapy to tenofovir alaferamide for chronic hepatitis B
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- Published online on: November 12, 2020 https://doi.org/10.3892/br.2020.1388
- Article Number: 12
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Copyright: © Sano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Abstract
Introduction
Hepatitis B virus (HBV) infection is the most common chronic viral infection worldwide, infecting ~2 billion individuals, of which >350 million are chronic HBV carriers (1). The development of nucleos(t)ide analogs (NAs) has revolutionized the management of chronic hepatitis B (CHB) in the last two decades (2). At present, five NAs have been approved as antiviral therapies for CHB in Japan. These agents are classified according to their chemical structures: Two nucleoside analogs that include lamivudine (LAM) and entecavir (ETV), two nucleotide analogs that include adefovir dipivoxil (ADV) and tenofovir disoproxil fumarate (TDF) (3), and the newly approved tenofovir alafenamide (TAF) (4-6). NAs are known to effectively suppress HBV replication and reduce the risk of disease progression and hepatic events (7). Long-term NA treatment has demonstrated effectiveness in improving histological findings and reducing the incidence of hepatocellular carcinoma (HCC) (8,9). Although NAs are generally safe and comparatively free of major side effects (10), renal and bone toxicity may occur in a small yet significant proportion of patients receiving older generation NAs, for example, ADV and TDF (11). Given the high number of patients receiving NAs worldwide, even a small risk of any of these toxicities can be translated into a major medical issue. TAF was approved in Japan for HBV treatment in 2017(12). Both TAF and TDF are phosphonamidite prodrugs of tenofovir (TFV) that share the same intracellular active metabolite, TFV diphosphate, which is effective against both HBV and human immunodeficiency virus (HIV)-1 infection (13,14). TAF has greater plasma stability, which allows for more efficient uptake by hepatocytes at lower plasma concentrations than TDF; thus, the circulating concentration of TFV is 90% lower after administration of a 25 mg dose of TAF than after a 300 mg dose of TDF (15). This difference likely contributes to the relatively better safety profile of TAF compared with TDF, particularly for renal and bone dysfunction. TAF was shown to have less influence on the glomerular filtration rate (GFR) and renal tubule function than TDF in international phase III trials (4-6). Long-term use of ADV and TDF has been reported, and there are several cases where renal and tubular dysfunction and bone metabolism abnormalities occurred (16-19). At present, few studies have reported the effect of switching to TAF after long-term use of other NAs (particularly the nucleotide group). Thus, the present study aimed to evaluate the effect of TAF (particularly on renal and tubular function) in patients with CHB who had received NA treatment.
Materials and methods
Patients
The present retrospective, single-center study included patients with chronic HBV infection. A total of 33 consecutive adult Japanese patients (mean age 61.5±8.7 years; 23 males and 10 females) who received TAF-based monotherapy (Vemlidy; Gilead Sciences KK) or a combination rescue therapy (including LAM and ETV combined) after using ADV and/or TDF between May 2017 and March 2019 at Kurume University Hospital were recruited. The exclusion criteria were as follows: i) Co-infection with HIV-1 or hepatitis C virus; ii) other liver diseases such as autoimmune hepatitis, alcoholic liver disease or metabolic liver disease; iii) decompensated cirrhosis; and iv) terminal illness.
This study was performed in accordance with the ethical principles described in the Declaration of Helsinki (20) and was approved by the Clinical Research Ethics Committee of Kurume University Hospital (approval no. 17209). Written informed consent was obtained from all patients.
Standard doses of LAM (100 mg/day), ADV (10 mg/day), ETV (0.5 mg/day), TDF (300 mg/day) and TAF (25 mg/day) were administered. The dosing interval of ADV and TDF was modified by the attending physician (once every 2 days) when the estimated GFR (eGFR) decreased to 50 ml/min/1.73 m2 or lower.
Study design
Biochemical (particularly renal tubular function and phosphorus metabolism) and virological markers were assessed at the start of TAF administration and 3 and 6 months after switching in all 33 cases. The patients were divided into two groups: Long-term NA administration (n=19) and short-term NA administration (n=14).
In Japan, NA compounds received insurance approvals at different times: LAM in 2000, ADV in 2004, ETV in 2006(21), TDF in 2014, and TAF in 2017. Reflecting on the above grouping, all patients who received NA treatment for ≥10 years were introduced with LAM and were included in the long-term group. Conversely, all patients who received NA therapy for <10 years were treated with an NA other than LAM and were included in the short-term group. Changes in biological and virological markers were compared between the two groups.
Data collection
All available medical records were evaluated thoroughly. Body mass index was calculated as weight (kg) divided by the square of height (m). Hypertension was defined as a clinical systolic blood pressure ≥140 mmHg and/or clinical diastolic blood pressure ≥90 mmHg, or the use of antihypertensive agents. Diabetes mellitus was diagnosed if the fasting blood glucose levels were >126 mg/dl or the HbA1c levels were >6.9%, according to the Diagnostic Criteria for Diabetes Mellitus (22) or by the documented use of antidiabetic agents or insulin. Blood and urine samples were collected in the morning after an overnight fast. The renal function was assessed by calculating the eGFR using the chronic kidney disease (CKD) epidemiology collaboration formula (23). The renal tubular function was assessed using a urine N-acetyl-β-D-glucosaminidase-creatinine ratio and urine β2-microglobulin-creatinine (U-BMG/Cr) ratio. The tubular metabolism of phosphates was assessed using a tubular maximum for phosphate corrected for the GFR (TmP/GFR) and tubular reabsorption of phosphate (TRP). TRP was calculated using the following formula: TRP=(1-urine phosphate/urine creatinine)x(serum creatinine/serum phosphate). The formula used to calculate TmP/GFR is dependent on the value of TRP and can be calculated using the following formulas: If TRP is ≤0.86, then TmP/GFR=TRP x serum phosphate; if TRP is >0.86, then TmP/GFR=0.3x TRP/(1-0.8x TRP)x serum phosphate (24).
Serum viral markers
The serum hepatitis B surface antigen (HBsAg) levels were determined using a chemiluminescence immunoassay (LUMIPULSE G1200 HBsAg-HQ assay kit; Fujirebio Inc.); the lower limit of detection was 0.005 IU/ml. The serum HBV DNA levels were determined using real-time TaqMan PCR assay (Cobas Taqman HBV test, Auto v2.0 kit, Roche Diagnostics, K.K); the lower limit of detection was 2.1 logcopies/ml. The serum hepatitis B e antigen (HBeAg) and hepatitis B e antibody (HBeAb) levels were determined using a chemiluminescence enzyme immunoassay (Architect HBeAg; HBeAb assay kit; Abbott Laboratory; cat. no. 6C32).
Statistical analysis
All data are presented as the mean ± standard deviation or as percentages. Differences between groups were compared using a χ2 test or a Mann-Whitney U test, where appropriate. All statistical analyses were performed using JMP Pro version 13 (SAS Institute). P<0.05 was considered to indicate a statistically significant difference.
Results
Baseline characteristics
Table I lists the baseline clinical and laboratory characteristics at the start of TAF therapy. In addition, Table SI lists the treatment history with NAs in all cases. The mean age of all patients was 61.5±8.7 years, and the majority of patients were male (70%). Moreover, 9 (27%) patients had arterial hypertension and 5 (15%) had diabetes mellitus. The mean duration of NA treatment was 11.2±6.3 years. A total of 21 patients (64%) had a history of ADV and 24 (73%) had a history of TDF treatment. The mean total duration of ADV treatment was 9.8±3.0 years, and the mean total duration of TDF treatment was 2.0±0.8 years. A total of 32 (97%) patients had chronic hepatitis and ADV had been administered for ~10 years. In addition, the backgrounds of the long-term and short-term administration groups were compared. A significant difference was observed between the administration periods of total NA (16.1±2.4 vs. 4.6±2.7 years; P<0.001) and ADV (10.5±2.1 vs. 3.3±0.4; P=0.027). Similarly, the rates of NA treatment history were different. Most patients with a history of LAM and ADV treatment were included in the long-term group. Other significant differences were found in the rates of hypertension (9 vs. 2; P<0.191) complications and HBeAg-positive (3 vs. 8; P=0.0240). Conversely, no significant differences were found in the other baseline characteristics amongst the two groups.
Time course observation of virological markers and hepatobiliary enzymes
Table II shows the time course of virological markers and hepatobiliary enzymes in all 33 cases after 3 and 6 months after switching to TAF. Regarding virological markers, HBsAg significantly decreased after 6 months (1,126±1,724 to 1,001±1,591 IU/ml; P<0.0001). As for hepatobiliary enzymes, the serum ALP levels significantly improved (320±126 to 283±124 U/l; P=0.028). In addition, the serum bone specific alkaline phosphatase (BAP) level, an ALP isozyme derived from bone (25,26), also improved after 6 months (19.7±9.0 to 17.7±8.0 µg/l; P=0.0006). Other virological markers and hepatobiliary enzymes did not show any significant changes.
Time course of observation of renal and tubular function and phosphorus metabolism
Table III shows the time course of renal and tubular functions and phosphorus metabolism in all 33 cases. U-BMG/Cr, which is associated with tubular function, was significantly improved after 6 months (5,224±17,471 to 3,547±14,652 µg/g x Cre; P=0.002). Regarding other renal and tubular functions, no significant changes in phosphorus metabolism were noted, and no problematic adverse reactions were observed after switching treatment regimens.
Comparison based on the duration of NA administration
Changes in viral markers, hepatobiliary enzymes, renal and tubular functions, and phosphorus metabolism between the long-term and short-term administration groups were compared and assessed. The results of each group are shown in Tables II and III. In the long-term group, the serum HBsAg levels were 590±641 and 537±598 IU/ml before switching to TAF and 6 months after switching, respectively (P=0.0108), and those of the short-term group were 1,853±2,400 and 1,631±2,235 IU/ml, respectively (P=0.0040). In the long-term group, the serum ALP levels were 324±141 and 302±151 U/l before switching and 6 months after switching, respectively (P=0.0281), and those of the short-term group were 298±86 and 257±69 U/l, respectively (P=0.0050). In the long-term group, the serum BAP levels were 21.1±11.0 and 19.2±9.7 µg/l before switching and 6 months after, respectively (P=0.0678), whereas in the short-term group, the values were 17.9±5.1 and 15.5±4.6 µg/l, respectively (P=0.0016). In the long-term group, the U-BMG/Cr ratios before switching and 6 months after switching were 8,635±23,026 and 5,815±19,200 µg/g·Cre, respectively (P=0.0017), whereas in the short-term group they were 951±1,455 and 469±549 µg/g·Cre, respectively (P=0.0052).
Fig. 1 shows the reduction in the HBsAg levels and the improvements in serum ALP, serum BAP and U-BMG/Cr levels in each group. The HBsAg levels decreased by 0.88±1.37 log-IU/ml in the long-term group and by 1.55±1.49 log-IU/ml in the short-term group, whereas the serum ALP levels improved by 8.1±11.9% in the long-term group and 12.2±12.8% in the short-term group. The serum BAP levels improved by 6.5±17.1% in the long-term group and 12.2±12.0% in the short-term group. U-BMG/Cr improved by 40.6±42.9% in the long-term group and by 32.1±34.3% in the short-term group. In summary, similar to the results seen in all 33 cases, a significant decrease in serum HBsAg levels and a significant improvement in serum ALP and U-BMG/Cr levels were observed in both groups. The serum BAP improved in both groups, but a significant improvement was observed only in the short-term group. HBsAg was significantly reduced in the short-term group compared with the long-term group (P=0.0432). No significant differences were found between the two groups in the other comparisons.
Discussion
The present study evaluated changes in biochemical (particularly renal and tubular functions and phosphorus metabolism) and virological markers in patients with CHB who switched from treatment with ADV or TDF therapy to TAF therapy. The results from the whole sample showed that the serum HBsAg and ALP levels and the U-BMG/Cr ratio were significantly decreased 6 months after switching. Within this period, no cases were found to have inadequate disease control due to a decrease in the antiviral effect and exacerbation of hepatobiliary enzymes.
Regarding the reduction in the HBsAg levels, Hagiwara et al (27) reported that it was particularly prominent in patients with serum HBsAg levels <800 IU/ml after switching from ETV to TAF. Uchida et al (28) found that the degree of reduction in serum HBsAg levels after switching from ETV to TAF was significantly higher, particularly in patients with cirrhosis, genotype B HBV infection and serum hepatitis B core related antigen levels <3.0 log U/ml. As mentioned above, some studies reported on factors contributing to the reduction in the serum HBsAg levels after switching from other NAs to TAF. In patients with low levels of HBV DNA who had a low risk of HCC, serum HBsAg levels were identified as an independent risk factor for the development of HCC (29). In addition, patients who received TDF treatment exhibit a reduced risk of developing HCC compared with those who received ETV treatment (30,31).
A possible mechanism underlying the difference in HCC risk is the induction of IFN-λ activity in patients treated with NAs, such as TDF and TAF, which would lead to the inhibition of HBsAg production and activation of an antitumor effect (32). As mentioned above, since the inhibitory effect of TFV on HCC development has been reported, it is necessary to examine not only the effect of reducing serum HBsAg levels in TAF but also the effect of reducing HCC risk in the future, but this was not evaluated in the present study. Moreover, renal and tubular functions were considered. Mitochondrial dysfunction of the proximal tubule cells is presumed to be a mechanism of renal dysfunction and the onset of ADV-related Fanconi syndrome (33). Fanconi syndrome is a disease that causes disorders of glucose, amino acid, phosphorus, and bicarbonate reabsorption in the proximal tubule of the kidney, and is often associated with osteomalacia (34). Renal tubular injury is characterized by a decrease in serum phosphorus and uric acid levels, an increase in U-BMG, and osteomalacia combined with elevation of the serum ALP levels (34,35). Previously, genetic polymorphisms of multidrug resistance-associated protein 2, which is involved in the excretion of ADV from the renal tubule, have been reported as factors contributing to renal impairment by ADV (36,37). Although ADV was changed to TDF in ADV-related Fanconi syndrome, TDF is structurally similar to ADV, and renal dysfunction and Fanconi syndrome due to TDF have also been reported. Therefore, as in ADV treatment, monitoring of renal and tubular functions is also required (17,18,38).
As an important clinical premise, tubular dysfunction may precede the decline in glomerular function. Tubular proteinuria implies the presence of increased amounts of small-sized proteins in the urine that are freely filtered in the glomerulus but reabsorbed by the proximal tubules (39,40). β2-microglobulinuria is prevalent amongst TFV-treated patients, even with normal GFR (39,40). In the present study, the mean overall eGFR was 73.4±13.7 ml/min/1.73 m2; although various patients had normal kidney function or mild CKD, the mean U-BMG/Cr was elevated (>300 µg/g·Cre was defined as abnormal) (41), indicating that tubular damage was already present. Primary tubular abnormalities, even severe, may be missed until they affect the glomerular function; thus, specific and early screening is necessary to prevent abnormalities.
Blood biochemical examination alone is insufficient to assess tubular dysfunction, and a regular urine test is recommended in patients undergoing NA treatment. This is also useful for evaluating phosphorous metabolism. Thus, how the duration of NA administration affected the transition of biochemical data was assessed with a focus on renal and tubular function after switching to TAF between the long-term and short-term groups. The U-BMG/Cr findings indicate that tubular injury was already present even in the short-term group. Similar to the whole-sample results, switching to TAF showed a significant improvement in serum ALP levels and in the U-BMG/Cr ratio in both groups. As shown in Fig. 1, an improvement in serum ALP levels and in the U-BMG/Cr ratio can be expected after this switch.
The important points of the present study were that these improvements were obtained regardless of the duration of the previous NA administration and that the effect was observed within 6 months after switching therapy. The incidence of tubular dysfunction has been reported to increase dramatically 8 years after the start of ADV administration (42). Thus, it is notable that the tubular dysfunction caused by long-term administration of NA, including ADV, is improved by switching to TAF. A real-world study also reported that switching from TDF to TAF significantly reduced tubular dysfunction markers, including the U-BMG/Cr and retinol-binding protein-creatinine ratio in 3 months (43). A previous study also reported that not only tubular dysfunction markers, but also eGFR, significantly improved 1 and 6 months after switching from TDF to TAF (44).
Most patients treated with NA combination therapy have already been treated for years or even decades. Furthermore, since complete eradication of HBV is exceedingly difficult with current treatments, continuous treatment is required. Based on previous reports and the present study, which found an improvement in a short period of time, switching to TAF in patients with renal and tubular dysfunction appears to be effective regardless of previous NA administration duration (43,44). Therefore, switching to TAF should be considered, even in patients treated with NAs who have not experienced side effects. Although a detailed examination was not performed in the present study, including analysis of changes in bone density, the improvement in serum ALP and BAP levels may reflect an improvement in bone metabolism. In fact, clinical trials and real-world studies have shown superior bone safety in patients treated with TAF compared with those treated with TDF (4-6,43).
The limitations of the present study are the small sample size, the short-term follow-up period, and the lack of a control group. The effects on serum HBsAg level reduction, renal tubular function and bone metabolism by switching from NA to TAF should be investigated in a larger cohort over a period of time. Considering the association between renal and bone dysfunction, long-term administration of ADV and TDF, and the increase in compliance due to the convenience of administration timing compared with ETV (45), if the antiviral effect is not inferior in the long term and is safer, it is expected that switching to TAF therapy will become more frequently recommended in the future. Further randomized clinical trials are required for selecting appropriate NAs.
In conclusion, switching from ADV or TDF to TAF confirmed a decrease in serum HBsAg and improvement in serum ALP levels and the U-BMG/Cr ratio after 6 months in patients regardless of length of NA administration history.
Supplementary Material
Treatment history with NAs in all cases.
Acknowledgements
The authors would like to thank Dr T. Kawaguchi, Dr T. Nakamura, Dr M. Nakano, Dr S. Okamura, Dr M. Abe and Dr S. Shimose, Division of Gastroenterology, Department of Internal Medicine, Kurume University School of Medicine for their contribution to this study.
Funding
No funding was received.
Availability of data and materials
The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
Authors' contributions
TS, KA, TI, TK, RK, TAH, HK, RK and TT obtained the biological samples. TS, KA, and TI analyzed the data. TS wrote the manuscript. All authors read and approved the final manuscript.
Ethics approval and consent to participate
This study was performed in accordance with the ethical principles of the Declaration of Helsinki and was approved by the Clinical Research Ethics Committee of Kurume University Hospital (approval no. 17209). Written informed consent was obtained from all patients.
Patient consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests.
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