Open Access

Functions of CD169 positive macrophages in human diseases (Review)

  • Authors:
    • Yu Liu
    • Yuan Xia
    • Chun-Hong Qiu
  • View Affiliations

  • Published online on: December 17, 2020     https://doi.org/10.3892/br.2020.1402
  • Article Number: 26
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

CD169+ macrophages are a unique type of macrophage subset that differ from M1 and M2 macrophages. CD169+ macrophages are present in multiple tissues and organs throughout the body and are primarily expressed in secondary lymphoid organs. These cells are primarily divided across three locations in secondary lymphoid organs: The metallophilic marginal zone of the spleen, the subcapsular sinus and the medulla of the lymph nodes. Due to their unique location distribution in vivo and the presence of the CD169 molecule on their surfaces, CD169+ macrophages are reported to serve important roles in several processes, such as phagocytosis, antigen presentation, immune tolerance, viral infection and inflammatory responses. At the same time, it has been reported that CD169+ macrophages may also serve an important role in anti‑tumour immunity. The present review focuses on the research progress surrounding the function of CD169+ macrophages in a variety of diseases, such as viral infection, autoimmune diseases and tumours.
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February-2021
Volume 14 Issue 2

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Copy and paste a formatted citation
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Spandidos Publications style
Liu Y, Xia Y and Qiu C: Functions of CD169 positive macrophages in human diseases (Review). Biomed Rep 14: 26, 2021.
APA
Liu, Y., Xia, Y., & Qiu, C. (2021). Functions of CD169 positive macrophages in human diseases (Review). Biomedical Reports, 14, 26. https://doi.org/10.3892/br.2020.1402
MLA
Liu, Y., Xia, Y., Qiu, C."Functions of CD169 positive macrophages in human diseases (Review)". Biomedical Reports 14.2 (2021): 26.
Chicago
Liu, Y., Xia, Y., Qiu, C."Functions of CD169 positive macrophages in human diseases (Review)". Biomedical Reports 14, no. 2 (2021): 26. https://doi.org/10.3892/br.2020.1402