Insulin-like growth factor-I and wound healing, a potential answer to non-healing wounds: A systematic review of the literature and future perspectives

Garoufalia,Zoe; Papadopetraki,Argyro; Karatza,Elli; Vardakostas,Dimitrios; Philippou,Anastassios; Kouraklis,Gregory; Mantas,Dimitrios

doi:10.3892/br.2021.1442

Insulin-like growth factor-I and wound healing, a potential answer to non-healing wounds: A systematic review of the literature and future perspectives

Authors:
- Zoe Garoufalia
- Argyro Papadopetraki
- Elli Karatza
- Dimitrios Vardakostas
- Anastassios Philippou
- Gregory Kouraklis
- Dimitrios Mantas
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Affiliations: Second Department of Propaedeutic Surgery, Laiko General Hospital, Athens 11527, Greece, Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece
Published online on: June 8, 2021 https://doi.org/10.3892/br.2021.1442
Article Number: 66

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Abstract

The induction of wound healing by insulin‑like growth factor‑I (IGF‑I) has been demonstrated in several animal studies; however, there are disproportionately fewer studies assessing its value in humans. The aim of the present review is to provide a comprehensive summary of all the available evidence pertaining to the effects of IGF‑I administration on the process of wound anaplasias, both in human tissues in vivo and in cells in vitro. A systematic search of Medline, Scopus and Google Scholar was performed for relevant studies published until May 2020. Overall, 11 studies were included. Of these, 2 studies were conducted in human subjects, whereas the rest of them were performed using in vitro models of human cell lines. All studies demonstrated a positive association between IGF‑I and wound anaplasias; IGF‑I promoted the migration of keratinocytes, thus playing an important role in wound epithelialization as well as enabling wound bed contraction, and it also stimulated hyaluronan synthesis. The wound healing‑promoting effect of IGF‑I may be a great asset in dealing with the healing of challenging wounds; thus, this type of treatment could be extremely useful in addressing patients with large burn wounds, chronic diabetic ulcers and patients with impaired wound healing. Nevertheless, the route of recombinant IGF‑I administration, the recommended dosage, as well as the indications for clinical use of this growth factor remain to be determined and thus, additional clinical trials are required, with a focus on the medical use of recombinant IGF‑I in wound anaplasias.

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