Changes in renal function increase the need for advanced ventilatory support and increase the risk of mortality in critically ill patients with COVID‑19

De Morais,Nickson Melo; De Morais Leone,Lara Candice Costa; De Almeida,Valéria Duarte; De Andrade,Micássio Fernandes; Do Nascimento,Ellany Gurgel Cosme; Fernandes,José Veríssimo; Bezerra,Christiane Medeiros; De Medeiros Fernandez,Thales Allyrio Araújo

doi:10.3892/br.2022.1501

Changes in renal function increase the need for advanced ventilatory support and increase the risk of mortality in critically ill patients with COVID‑19

Authors:
- Nickson Melo De Morais
- Lara Candice Costa De Morais Leone
- Valéria Duarte De Almeida
- Micássio Fernandes De Andrade
- Ellany Gurgel Cosme Do Nascimento
- José Veríssimo Fernandes
- Christiane Medeiros Bezerra
- Thales Allyrio Araújo De Medeiros Fernandez
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Affiliations: Multicentric Postgraduate Program in Physiological Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil, Department of Biomedical Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil, Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59078‑970, Brazil
Published online on: January 31, 2022 https://doi.org/10.3892/br.2022.1501
Article Number: 18

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Abstract

In addition to respiratory failure, another important outcome presented by patients hospitalized with coronavirus disease 2019 (COVID‑19) is renal failure, which is related to increased severity of infection and a greater risk of mortality. Severity is often represented by the need for respiratory and/or life support, which can range from oxygen therapy to invasive mechanical ventilation. This study aimed to determine the association between the degree of renal and inflammatory impairment in patients with the need for advanced respiratory support and mortality. Included in the present study were 79 critically ill patients with COVID‑19 on different days, who required a nasal cannula and/or orotracheal intubation. Data from laboratory tests, arterial blood gases and information on their clinical evolution were collected. The results obtained showed that the biochemical markers of renal function, as well as the inflammatory markers and the partial pressure of carbon dioxide, were significantly increased in patients who succumbed to the infection. Similarly, these markers were higher amongst patients who required increased respiratory assistance.

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