1
|
GBD 2015 Obesity Collaborators. Afshin A,
Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, Marczak L,
Mokdad AH, Moradi-Lakeh M, et al: Health effects of overweight and
obesity in 195 countries over 25 years. N Engl J Med. 377:13–27.
2017.PubMed/NCBI View Article : Google Scholar
|
2
|
Gregg EW and Shaw JE: Global health
effects of overweight and obesity. N Engl J Med. 377:80–81.
2017.PubMed/NCBI View Article : Google Scholar
|
3
|
Spiegelman BM and Flier JS: Obesity and
the regulation of energy balance. Cell. 104:531–543.
2001.PubMed/NCBI View Article : Google Scholar
|
4
|
Madsen MS, Siersbæk Boergesen M, Nielsen R
and Mandrup S: Peroxisome proliferator-activated receptor γ and
C/EBPα synergistically activate key metabolic adipocyte genes by
assisted loading. Mol Cell Biol. 34:939–954. 2014.PubMed/NCBI View Article : Google Scholar
|
5
|
Zhao P and Stephens JM: Identification of
STAT target genes in adipocytes. JAKSTAT. 2(e23092)2013.PubMed/NCBI View Article : Google Scholar
|
6
|
Zhang K, Guo W, Yang Y and Wu J:
JAK2/STAT3 pathway is involved in the early stage of adipogenesis
through regulating C/EBPβ transcription. J Cell Biochem.
112:488–497. 2011.PubMed/NCBI View Article : Google Scholar
|
7
|
Wu Z, Rosen ED, Brun R, Hauser S, Adelmant
G, Troy AE, McKeon C, Darlington GJ and Spiegelman BM:
Cross-regulation of C/EBP alpha and PPAR gamma controls the
transcriptional pathway of adipogenesis and insulin sensitivity.
Mol Cell. 3:151–158. 1999.PubMed/NCBI View Article : Google Scholar
|
8
|
Janovská A, Hatzinikolas G, Staikopoulos
V, Mcinerney J, Mano M and Wittert GA: AMPK and ACC
phosphorylation: Effect of leptin, muscle fibre type and obesity.
Mol Cell Endocrinol. 284:1–10. 2008.PubMed/NCBI View Article : Google Scholar
|
9
|
Garcia A, Sekowski A, Subramanian V and
Brasaemle DL: The central domain is required to target and anchor
perilipin A to lipid droplets. J Biol Chem. 278:625–635.
2003.PubMed/NCBI View Article : Google Scholar
|
10
|
Schweiger M, Eichmann TO, Taschler U,
Zimmermann R, Zechner R and Lass A: Measurement of lipolysis.
Methods Enzymol. 538:171–193. 2014.PubMed/NCBI View Article : Google Scholar
|
11
|
Hsieh PS, Jin JS, Chiang CF, Chan PC, Chen
CH and Shih KC: COX-2-mediated inflammation in fat is crucial for
obesity-linked insulin resistance and fatty liver. Obesity (Silver
Spring). 17:1150–1157. 2009.PubMed/NCBI View Article : Google Scholar
|
12
|
Hotamisligil GS, Shargill NS and
Spiegelman BM: Adipose expression of tumor necrosis factor-alpha:
Direct role in obesity-linked insulin resistance. Science.
259:87–91. 1993.PubMed/NCBI View Article : Google Scholar
|
13
|
Fuster JJ, Ouchi N, Gokce N and Walsh K:
Obesity-induced changes in adipose tissue microenvironment and
their impact on cardiovascular disease. Circ Res. 118:1786–1807.
2016.PubMed/NCBI View Article : Google Scholar
|
14
|
Kim HL, Ha AW and Kim WK: Effect of
saccharin on inflammation in 3T3-L1 adipocytes and the related
mechanism. Nutr Res Pract. 14:109–116. 2020.PubMed/NCBI View Article : Google Scholar
|
15
|
Cheng AW, Tan X, Sun JY, Gu CM, Liu C and
Guo X: Catechin attenuates TNF-α induced inflammatory response via
AMPK-SIRT1 pathway in 3T3-L1 adipocytes. PLoS One.
14(e0217090)2019.PubMed/NCBI View Article : Google Scholar
|
16
|
Li Y, Yang P, Chang Q, Wang J, Liu J, Lv
Y, Wang TTY, Gao B, Zhang Y and Yu LL: Inhibitory effect of
piceatannol on TNF-α-mediated inflammation and insulin resistance
in 3T3-L1 Adipocytes. J Agric Food Chem. 65:4634–4641.
2017.PubMed/NCBI View Article : Google Scholar
|
17
|
Kwon HS, Jeong GS and Jang BC:
Cudratricusxanthone A inhibits lipid accumulation and expression of
inducible nitric oxide synthase in 3T3-L1 preadipocytes. Int J Mol
Sci. 22(505)2021.PubMed/NCBI View Article : Google Scholar
|
18
|
Yadav AK and Jang BC: Inhibition of lipid
accumulation and cyclooxygenase-2 expression in differentiating
3T3-L1 preadipocytes by pazopanib, a multikinase inhibitor. Int J
Mol Sci. 22(4884)2021.PubMed/NCBI View Article : Google Scholar
|
19
|
Van Gils C and Cox PA: Ethnobotany of
nutmeg in the spice islands. J Ethnopharmacol. 42:117–124.
1994.PubMed/NCBI View Article : Google Scholar
|
20
|
Nguyen PH, Le TVT, Kang HW, Chae J, Kim
SK, Kwon KI, Seo DB, Lee SJ and Oh WK: AMP-activated protein kinase
(AMPK) activators from Myristica fragrans (nutmeg) and their
anti-obesity effect. Bioorg Med Chem Lett. 20:4128–4131.
2010.PubMed/NCBI View Article : Google Scholar
|
21
|
Cho JY, Choi GJ, Son SW, Jang KS, Lim HK,
Lee SO, Sung ND, Cho KY and Kim JC: Isolation and antifungal
activity of lignans from Myristica fragrans against various
plant pathogenic fungi. Pest Manag Sci. 63:935–940. 2007.PubMed/NCBI View
Article : Google Scholar
|
22
|
Zhao W, Guo M, Feng J, Gu Z, Zhao J, Zhang
H, Wang G and Chen W: Myristica fragrans extract regulates
gut microbes and metabolites to attenuate hepatic inflammation and
lipid metabolism disorders via the AhR-FAS and NF-κB signaling
pathways in mice with non-alcoholic fatty liver disease. Nutrients.
14(1699)2022.PubMed/NCBI View Article : Google Scholar
|
23
|
Zhao W, Song F, Hu D, Chen H, Zhai Q, Lu
W, Zhao J, Zhang H, Chen W, Gu Z and Wang G: The protective effect
of Myristica fragrans Houtt. Extracts against obesity and
inflammation by regulating free fatty acids metabolism in
nonalcoholic fatty liver disease. Nutrients.
12(2507)2020.PubMed/NCBI View Article : Google Scholar
|
24
|
Lesmana R, Siannoto M, Nugraha GI,
Goenawan H, Feinisa AK, Pratiwi YS, Veronica F, Tarawan VM,
Susianti S and Supratman U: Nutmeg extract potentially alters
characteristics of white adipose tissue in rats. Vet Med Sci.
7:512–520. 2021.PubMed/NCBI View
Article : Google Scholar
|
25
|
Hien TT, Oh WK, Nguyen PH, Oh SJ, Lee MY
and Kang KW: Nectandrin B activates endothelial nitric-oxide
synthase phosphorylation in endothelial cells: Role of the
AMP-activated protein kinase/estrogen receptor
α/phosphatidylinositol 3-kinase/Akt pathway. Mol Pharmacol.
80:1166–1178. 2011.PubMed/NCBI View Article : Google Scholar
|
26
|
Smith M: Nutmeg. In: Encyclopedia of
Toxicology. 3rd edition. Elsevier, Amsterdam, pp630-631, 2014.
|
27
|
Götz ME, Sachse B, Schäfer B and
Eisenreich A: Myristicin and elemicin: Potentially
toxicalkenylbenzenes in food. Foods. 11(1988)2022.PubMed/NCBI View Article : Google Scholar
|
28
|
Jang HJ, Yang KE, Oh WK, Lee SI, Hwang IH,
Ban KT, Yoo HS, Choi JS, Yeo EJ and Jang IS: Nectandrin B-mediated
activation of the AMPK pathway prevents cellular senescence in
human diploid fibroblasts by reducing intracellular ROS levels.
Aging (Albany NY). 11:3731–3749. 2019.PubMed/NCBI View Article : Google Scholar
|
29
|
Pratiwi YS, Lesmana R, Goenawan H,
Sylviana N, Setiawan I, Tarawan VM, Lestari K, Abdulah R, Dwipa L,
Purba A and Supratman U: Nutmeg extract increases skeletal muscle
mass in aging rats partly via IGF1-Akt-mTOR pathway and inhibition
of autophagy. Evid Based Complement Alternat Med.
2018(2810840)2018.PubMed/NCBI View Article : Google Scholar
|
30
|
Lee JH, Kang H, Ban KT, Kim BK, Lee JH,
Hwang H, Yoo HS, Cho K and Choi JS: Proteome network analysis of
skeletal muscle in lignan-enriched nutmeg extract fed mice. J Anal
Sci Tech. 14(11)2023.
|
31
|
Greenberg AS, Shen WJ, Muliro K, Patel S,
Souza SC, Roth RA and Kraemer FB: Stimulation of lipolysis and
hormone-sensitive lipase via the extracellular signal-regulated
kinase pathway. J Biol Chem. 276:45456–45461. 2001.PubMed/NCBI View Article : Google Scholar
|
32
|
Rosen ED, Hsu CH, Wang X, Sakai S, Freeman
MW, Gonzalez FJ and Spiegelman BM: C/EBPalpha induces adipogenesis
through PPARgamma: A unified pathway. Genes Dev. 16:22–26.
2002.PubMed/NCBI View Article : Google Scholar
|
33
|
Stephens JM, Morrison RF and Pilch PF: The
expression and regulation of STATs during 3T3-L1 adipocyte
differentiation. J Biol Chem. 271:10441–10444. 1996.PubMed/NCBI View Article : Google Scholar
|
34
|
Gong Z, Huang C, Sheng X, Zhang Y, Li Q,
Wang M-W, Peng L and Zang YQ: The role of tanshinone IIA in the
treatment of obesity through peroxisome proliferator-activated
receptor gamma antagonism. Endocrinology. 150:104–113.
2009.PubMed/NCBI View Article : Google Scholar
|
35
|
Farmer SR: Transcriptional control of
adipocyte formation. Cell Metab. 4:263–273. 2006.PubMed/NCBI View Article : Google Scholar
|
36
|
Richard AJ and Stephens JM: The role of
JAK-STAT signaling in adipose tissue function. Biochim Biophys
Acta. 1842:431–439. 2014.PubMed/NCBI View Article : Google Scholar
|
37
|
Wang D, Zhou Y, Lei W, Zhang K, Shi J, Hu
Y, Shu G and Song J: Signal transducer and activator of
transcription 3 (STAT3) regulates adipocyte differentiation via
peroxisome-proliferator-activated receptor gamma (PPARgamma). Biol
Cell. 102:1–12. 2009.PubMed/NCBI View Article : Google Scholar
|
38
|
Collins JM, Neville MJ, Pinnick KE, Hodson
L, Ruyter B, van Dijk TH, Reijngoud DJ, Fielding MD and Frayn KN:
De novo lipogenesis in the differentiating human adipocyte can
provide all fatty acids necessary for maturation. J Lipid Res.
52:1683–1692. 2011.PubMed/NCBI View Article : Google Scholar
|
39
|
Tansey JT, Sztalryd C, Hlavin EM, Kimmel
AR and Londos C: The central role of perilipin a in lipid
metabolism and adipocyte lipolysis. IUBMB Life. 56:379–385.
2004.PubMed/NCBI View Article : Google Scholar
|
40
|
Swierczyński J and Sledziński T: Metabolic
and regulatory function of fatty acid synthase. Postepy Biochem.
58:175–185. 2012.PubMed/NCBI(In Polish).
|
41
|
Jensen-Urstad APL and Semenkovich CF:
Fatty acid synthase and liver triglyceride metabolism: Housekeeper
or messenger? Biochim Biophys Acta. 1821:747–753. 2012.PubMed/NCBI View Article : Google Scholar
|
42
|
Itabe H, Yamaguchi T, Nimura S and Sasabe
N: Perilipins: A diversity of intracellular lipid droplet proteins.
Lipids Health Dis. 16(83)2017.PubMed/NCBI View Article : Google Scholar
|
43
|
Kern PA, Gregorio GD, Lu T, Rassouli N and
Ranganathan G: Perilipin expression in human adipose tissue is
elevated with obesity. J Clin Endocrinol Metab. 89:1352–1358.
2004.PubMed/NCBI View Article : Google Scholar
|
44
|
Langin D: Control of fatty acid and
glycerol release in adipose tissue lipolysis. C R Biol.
329:598–607. 2006.PubMed/NCBI View Article : Google Scholar
|
45
|
Althaher AR: An overview of
hormone-sensitive lipase (HSL). ScientificWorldJournal.
2022(1964684)2022.PubMed/NCBI View Article : Google Scholar
|
46
|
Kraemer FB and Shen WJ: Hormone-sensitive
lipase: control of intracellular tri-(di-)acylglycerol and
cholesteryl ester hydrolysis. J Lipid Res. 43:1585–1594.
2002.PubMed/NCBI View Article : Google Scholar
|
47
|
McDonough PM, Ingermanson RS, Loy PA, Koon
ED, Whittaker R, Laris CA, Hilton JM, Nicoll JB, Buehrer BM and
Price JH: Quantification of hormone sensitive lipase
phosphorylation and colocalization with lipid droplets in murine
3T3L1 and human subcutaneous adipocytes via automated digital
microscopy and high-content analysis. Assay Drug Dev Technol.
9:262–280. 2011.PubMed/NCBI View Article : Google Scholar
|
48
|
Xu H, Barnes GT, Yang Q, Tan G, Yang D,
Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA and Chen H:
Chronic inflammation in fat plays a crucial role in the development
of obesity-related insulin resistance. J Clin Invest.
112:1821–1830. 2003.PubMed/NCBI View Article : Google Scholar
|
49
|
Roy PK, Islam J and Lalhlenmawia H:
Prospects of potential adipokines as therapeutic agents in
obesity-linked atherogenic dyslipidemia and insulin resistance.
Egypt Heart J. 75(24)2023.PubMed/NCBI View Article : Google Scholar
|
50
|
Ouchi N, Parker JL, Lugus JJ and Walsh K:
Adipokines in inflammation and metabolic disease. Nat Rev Immunol.
11:85–97. 2011.PubMed/NCBI View Article : Google Scholar
|
51
|
Chan PC, Liao MT and Hsieh PS: The
dualistic effect of COX-2-mediated signaling in obesity and insulin
resistance. Int J Mol Sci. 20(3115)2019.PubMed/NCBI View Article : Google Scholar
|