Open Access

Short‑term effects of oxybutynin dosage in individuals with neurogenic bladder following spinal cord injury: A retrospective cohort study

  • Authors:
    • Sirintip Boonjaraspinyo
    • Jittima Saengsuwan
    • Patpiya Sirasaporn
    • Bandit Thinkhamrop
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  • Published online on: July 26, 2024     https://doi.org/10.3892/br.2024.1823
  • Article Number: 135
  • Copyright: © Boonjaraspinyo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to determine the relationship between dose of oxybutynin and reduction in detrusor pressure in individuals with neurogenic bladder (NGB) secondary to spinal cord injury (SCI). The hospital‑based data were examined for all individuals with NGB and SCI who were admitted for urological evaluation between January 1999 and December 2016. Patient characteristics, urodynamics and bladder management details were collected at pre‑treatment and post‑treatment. The primary outcome used to assess oxybutynin treatment was the change in detrusor pressure (Pdet). Analysis of covariance (ANCOVA) was used to investigate the relationship between dosage of oxybutynin and decrease in Pdet. A total of 245 participants (112 who received no medication and 133 treated with oxybutynin) were included. After controlling for confounding factors, each 1 mg increase in oxybutynin was associated with a mean decrease of 0.9 cmH2O in Pdet (95% CI, ‑1.4 to ‑0.3). Stratifying bladder management by indwelling catheter, oxybutynin at a dose of 1 mg was associated with a mean decrease in Pdet of 0.5 cmH2O (95% CI, ‑1.4 to 0.4) in patients with indwelling catheters and 1.0 cmH2O (95% CI, ‑1.7 to ‑0.3) in patients with clean intermittent catheterization and balanced bladder. This study provided guidance for setting the starting dose of drugs associated with response variability in NGB with SCI. Oxybutynin is deemed to be clinically effective for managing NGB in patients with SCI. 
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September-2024
Volume 21 Issue 3

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Spandidos Publications style
Boonjaraspinyo S, Saengsuwan J, Sirasaporn P and Thinkhamrop B: Short‑term effects of oxybutynin dosage in individuals with neurogenic bladder following spinal cord injury: A retrospective cohort study. Biomed Rep 21: 135, 2024.
APA
Boonjaraspinyo, S., Saengsuwan, J., Sirasaporn, P., & Thinkhamrop, B. (2024). Short‑term effects of oxybutynin dosage in individuals with neurogenic bladder following spinal cord injury: A retrospective cohort study. Biomedical Reports, 21, 135. https://doi.org/10.3892/br.2024.1823
MLA
Boonjaraspinyo, S., Saengsuwan, J., Sirasaporn, P., Thinkhamrop, B."Short‑term effects of oxybutynin dosage in individuals with neurogenic bladder following spinal cord injury: A retrospective cohort study". Biomedical Reports 21.3 (2024): 135.
Chicago
Boonjaraspinyo, S., Saengsuwan, J., Sirasaporn, P., Thinkhamrop, B."Short‑term effects of oxybutynin dosage in individuals with neurogenic bladder following spinal cord injury: A retrospective cohort study". Biomedical Reports 21, no. 3 (2024): 135. https://doi.org/10.3892/br.2024.1823