Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study

  • Authors:
    • Serena Spampinato
    • Giuseppe Nicolò Conti
    • Andrea Marino
    • Vincenzo Raimondo
    • Benedetto Maurizio Celesia
    • Giovanni Francesco Pellicanò
    • Mariangela Valentina Puci
    • Giovanni Sotgiu
    • Roberto Bruno
    • Nunziatina Villari
    • Alessia Mirabile
    • Viviana Agata Maria Coco
    • Michele Salvatore Paternò Raddusa
    • Eugenia Pistarà
    • Vincenzo Boscia
    • Viviana Fisicaro
    • Giorgia Fiorenza
    • Bruno Cacopardo
    • Emmanuele Venanzi Rullo
    • Giuseppe Nunnari
  • View Affiliations

  • Published online on: October 2, 2024     https://doi.org/10.3892/br.2024.1867
  • Article Number: 179
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Abstract

Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), as a fixed dosed combination, is effective in people living with human immunodeficiency virus (PLWH) previously treated with other therapeutic regimens. The aim of the present retrospective observational real‑life study was to analyze virological suppression and immunological, metabolic and safety profile of B/F/TAF. Data were collected from 127 PLHW who switched from any regimen to B/F/TAF. Viral load and virological suppression (viral load <50 copies/ml) were assessed by using real‑time PCR methodologies; CD4 and CD8 T cell count as well as CD4/CD8 ratio were determined by cytofluorimetric analyses; other metabolic parameters such as total cholesterol, triglycerides, High‑ and Low‑Density Lipoproteins were assessed by using immunoenzymatic assay. All of the aforementioned parameters were assessed at different timepoints (Baseline, 48 and 96 weeks) for the patients switching to B/F/TAF. Of 127 PLHW [96 (75.6%) male and 31 (24.4%) female, with a mean age of 46.8±10.7 years], 107 PLHW were included in the analysis. The percentage of virologically suppressed PLWH increased from 66.4 to 74.8% at 96 weeks. A statistically significant increase in absolute CD4 (P<0.0001) and CD8 T cell count (P=0.002) was observed. Of importance, there was a significant increase in CD4/CD8 ratio from 0.95 (0.52‑1.31) to 1.16 (0.75‑1.39) (P=0.003) after 96 weeks. There was a significant decrease in the median values ​​of triglycerides (P<0.0001) and total cholesterol (P<0.0001). Serum creatinine showed a significant increase (P=0.0001). In real life, switching to B/F/T was safe and highly effective both virologically and immunologically. Decrease in cholesterol and triglyceride levels suggested a favorable metabolic profile, which may decrease inflammation, leading to a healthier state and less organ damage.
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December-2024
Volume 21 Issue 6

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Spandidos Publications style
Spampinato S, Conti GN, Marino A, Raimondo V, Celesia BM, Pellicanò GF, Puci MV, Sotgiu G, Bruno R, Villari N, Villari N, et al: Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study. Biomed Rep 21: 179, 2024.
APA
Spampinato, S., Conti, G.N., Marino, A., Raimondo, V., Celesia, B.M., Pellicanò, G.F. ... Nunnari, G. (2024). Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study. Biomedical Reports, 21, 179. https://doi.org/10.3892/br.2024.1867
MLA
Spampinato, S., Conti, G. N., Marino, A., Raimondo, V., Celesia, B. M., Pellicanò, G. F., Puci, M. V., Sotgiu, G., Bruno, R., Villari, N., Mirabile, A., Coco, V. A., Paternò Raddusa, M. S., Pistarà, E., Boscia, V., Fisicaro, V., Fiorenza, G., Cacopardo, B., Rullo, E. V., Nunnari, G."Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study". Biomedical Reports 21.6 (2024): 179.
Chicago
Spampinato, S., Conti, G. N., Marino, A., Raimondo, V., Celesia, B. M., Pellicanò, G. F., Puci, M. V., Sotgiu, G., Bruno, R., Villari, N., Mirabile, A., Coco, V. A., Paternò Raddusa, M. S., Pistarà, E., Boscia, V., Fisicaro, V., Fiorenza, G., Cacopardo, B., Rullo, E. V., Nunnari, G."Enhanced metabolic health and immune response with bictegravir/emtricitabine/TAF: Insights from a 96‑week retrospective study". Biomedical Reports 21, no. 6 (2024): 179. https://doi.org/10.3892/br.2024.1867