Correlating tissue and plasma‑specific piRNA changes to predict their possible role in pancreatic malignancy and chronic inflammation
- Authors:
- Barsha Saha
- Shouvik Chakravarty
- Sukanta Ray
- Hemabha Saha
- Kshaunish Das
- Indranil Ghosh
- Bibekanand Mallick
- Nidhan K. Biswas
- Srikanta Goswami
-
Affiliations: Biotechnology Research and Innovation Council-National Institute of Biomedical Genomics, Kalyani, Nadia, West Bengal 741251, India, Institute of Postgraduate Medical Education & Research, Kolkata 700020, India, Chittaranjan National Cancer Institute, Kolkata 700026, India, National Institute of Technology, Rourkela 769008, India - Published online on: October 7, 2024 https://doi.org/10.3892/br.2024.1874
- Article Number: 186
-
Copyright: © Saha et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
 |
 |
 |
 |
|
Bengtsson A, Andersson R and Ansari D: The actual 5-year survivors of pancreatic ductal adenocarcinoma based on real-world data. Sci Rep. 10(16425)2020.PubMed/NCBI View Article : Google Scholar | |
|
Zhang L, Sanagapalli S and Stoita A: Challenges in diagnosis of pancreatic cancer. World J Gastroenterol. 24:2047–2060. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Lee ES and Lee JM: Imaging diagnosis of pancreatic cancer: A state-of-the-art review. World J Gastroenterol. 20:7864–7877. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Poruk KE, Gay DZ, Brown K, Mulvihill JD, Boucher KM, Scaife CL, Firpo MA and Mulvihill SJ: The clinical utility of CA 19-9 in pancreatic adenocarcinoma: Diagnostic and prognostic updates. Curr Mol Med. 13:340–351. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Kim S, Park BK, Seo JH, Choi J, Choi JW, Lee CK, Chung JB, Park Y and Kim DW: Carbohydrate antigen 19-9 elevation without evidence of malignant or pancreatobiliary diseases. Sci Rep. 10(8820)2020.PubMed/NCBI View Article : Google Scholar | |
|
Wang K, Wang X, Pan Q and Zhao B: Liquid biopsy techniques and pancreatic cancer: Diagnosis, monitoring, and evaluation. Mol Cancer. 22(167)2023.PubMed/NCBI View Article : Google Scholar | |
|
Yan H and Bu P: Non-coding RNA in cancer. Essays Biochem. 65:625–639. 2021.PubMed/NCBI View Article : Google Scholar | |
|
Li Y, Al Hallak MN, Philip PA, Azmi AS and Mohammad RM: Non-coding RNAs in pancreatic cancer diagnostics and therapy: Focus on lncRNAs, circRNAs, and piRNAs. Cancers (Basel). 13(4161)2021.PubMed/NCBI View Article : Google Scholar | |
|
Liu Y, Dou M, Song X, Dong Y, Liu S, Liu H, Tao J, Li W, Yin X and Xu W: The emerging role of the piRNA/piwi complex in cancer. Mol Cancer. 18(123)2019.PubMed/NCBI View Article : Google Scholar | |
|
Wu Z, Yu X, Zhang S, He Y and Guo W: Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases. Cell Commun Signal. 21(343)2023.PubMed/NCBI View Article : Google Scholar | |
|
Limanówka P, Ochman B and Świętochowska E: PiRNA obtained through liquid biopsy as a possible cancer biomarker. Diagnostics (Basel). 13(1895)2023.PubMed/NCBI View Article : Google Scholar | |
|
Müller S, Raulefs S, Bruns P, Afonso-Grunz F, Plötner A, Thermann R, Jäger C, Schlitter AM, Kong B, Regel I, et al: Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer. Mol Cancer. 14(94)2015.PubMed/NCBI View Article : Google Scholar | |
|
Li W, Gonzalez-Gonzalez M, Sanz-Criado L, Garcia-Carbonero N, Celdran A, Villarejo-Campos P, Minguez P, Pazo-Cid R, Garcia-Jimenez C, Orta-Ruiz A, et al: A novel PiRNA enhances CA19-9 sensitivity for pancreatic cancer identification by liquid biopsy. J Clin Med. 11(7310)2022.PubMed/NCBI View Article : Google Scholar | |
|
Kumar SR, Kimchi ET, Manjunath Y, Gajagowni S, Stuckel AJ and Kaifi JT: RNA cargos in extracellular vesicles derived from blood serum in pancreas associated conditions. Sci Rep. 10(2800)2020.PubMed/NCBI View Article : Google Scholar | |
|
Xie J, Xing S, Shen BY, Chen HT, Sun B, Wang ZT, Wang JW and Lu XX: PIWIL1 interacting RNA piR-017061 inhibits pancreatic cancer growth via regulating EFNA5. Hum Cell. 34:550–563. 2021.PubMed/NCBI View Article : Google Scholar | |
|
Zhong Y, Tian Y, Wang Y, Bai J, Long Q, Yan L, Gong Z, Gao W and Tang Q: Small extracellular vesicle piR-hsa-30937 derived from pancreatic neuroendocrine neoplasms upregulates CD276 in macrophages to promote immune evasion. Cancer Immunol Res. 12:840–853. 2024.PubMed/NCBI View Article : Google Scholar | |
|
Chhatriya B, Mukherjee M, Ray S, Sarkar P, Chatterjee S, Nath D, Das K and Goswami S: Comparison of tumour and serum specific microRNA changes dissecting their role in pancreatic ductal adenocarcinoma: A meta-analysis. BMC Cancer. 19(1175)2019.PubMed/NCBI View Article : Google Scholar | |
|
Andrews S: FastQC: A quality control tool for high throughput sequence data, 2010. | |
|
Ewels P, Magnusson M, Lundin S and Käller M: MultiQC: Summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 32:3047–3048. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Krueger F: Trim Galore: A wrapper tool around Cutadapt and FastQC to consistently apply quality and adapter trimming to FastQ files, with some extra functionality for MspI-digested RRBS-type (reduced representation bisufite-seq) libraries, 2012. | |
|
Langmead B and Salzberg SL: Fast gapped-read alignment with Bowtie 2. Nat Methods. 9:357–359. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G and Durbin R: 1000 Genome Project Data Processing Subgroup. The sequence alignment/map format and SAMtools. Bioinformatics. 25:2078–2079. 2009.PubMed/NCBI View Article : Google Scholar | |
|
Tarasov A, Vilella AJ, Cuppen E, Nijman IJ and Prins P: Sambamba: Fast processing of NGS alignment formats. Bioinformatics. 31:2032–2034. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Garcia-Alcalde F, Okonechnikov K, Carbonell J, Cruz LM, Götz S, Tarazona S, Dopazo J, Meyer TF and Conesa A: Qualimap: Evaluating next-generation sequencing alignment data. Bioinformatics. 28:2678–2679. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Leung YY, Kuksa PP, Amlie-Wolf A, Valladares O, Ungar LH, Kannan S, Gregory BD and Wang LS: DASHR: Database of small human noncoding RNAs. Nucleic Acids Res. 44:D216–D222. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Liao Y, Smyth GK and Shi W: featureCounts: An efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 30:923–930. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Piuco R and Galante PAF: piRNAdb: A piwi-interacting RNA database. bioRxiv, 2021. | |
|
Love MI, Huber W and Anders S: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15(550)2014.PubMed/NCBI View Article : Google Scholar | |
|
Riffo-Campos AL, Riquelme I and Brebi-Mieville P: Tools for sequence-based miRNA target prediction: What to choose? Int J Mol Sci. 17(1987)2016.PubMed/NCBI View Article : Google Scholar | |
|
Das B, Jain N and Mallick B: piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair. Commun Biol. 4(1312)2021.PubMed/NCBI View Article : Google Scholar | |
|
Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV, Clark NR and Ma'ayan A: Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics. 14(128)2013.PubMed/NCBI View Article : Google Scholar | |
|
Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z, Koplev S, Jenkins SL, Jagodnik KM, Lachmann A, et al: Enrichr: A comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 44:W90–W97. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Yamanaka S, Siomi MC and Siomi H: piRNA clusters and open chromatin structure. Mob DNA. 5(22)2014.PubMed/NCBI View Article : Google Scholar | |
|
Rosenkranz D and Zischler H: proTRAC-a software for probabilistic piRNA cluster detection, visualization and analysis. BMC Bioinformatics. 13(5)2012.PubMed/NCBI View Article : Google Scholar | |
|
Chen N: Using RepeatMasker to identify repetitive elements in genomic sequences. Curr Protoc Bioinformatics Chapter 4: Unit 4.10, 2004. | |
|
Quinlan AR and Hall IM: BEDTools: A flexible suite of utilities for comparing genomic features. Bioinformatics. 26:841–842. 2010.PubMed/NCBI View Article : Google Scholar | |
|
Zuo Y, Liang Y, Zhang J, Hao Y, Li M, Wen Z and Zhao Y: Transcriptome analysis identifies piwi-interacting RNAs as prognostic markers for recurrence of prostate cancer. Front Genet. 10(1018)2019.PubMed/NCBI View Article : Google Scholar | |
|
Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, et al: Initial sequencing and analysis of the human genome. Nature. 409:860–921. 2001.PubMed/NCBI View Article : Google Scholar | |
|
El-Sawy M, Kale SP, Dugan C, Nguyen TQ, Belancio V, Bruch H, Roy-Engel AM and Deininger PL: Nickel stimulates L1 retrotransposition by a post-transcriptional mechanism. J Mol Biol. 354:246–257. 2005.PubMed/NCBI View Article : Google Scholar | |
|
Giorgi G, Marcantonio P and Del Re B: LINE-1 retrotransposition in human neuroblastoma cells is affected by oxidative stress. Cell Tissue Res. 346:383–391. 2011.PubMed/NCBI View Article : Google Scholar | |
|
Stribinskis V and Ramos KS: Activation of human long interspersed nuclear element 1 retrotransposition by benzo(a)pyrene, an ubiquitous environmental carcinogen. Cancer Res. 66:2616–2620. 2006.PubMed/NCBI View Article : Google Scholar | |
|
Prinz C, Fehring L and Frese R: MicroRNAs as indicators of malignancy in pancreatic ductal adenocarcinoma (PDAC) and cystic pancreatic lesions. Cells. 11(2374)2022.PubMed/NCBI View Article : Google Scholar | |
|
Mok ETY, Chitty JL and Cox TR: miRNAs in pancreatic cancer progression and metastasis. Clin Exp Metastasis. 41:163–186. 2024.PubMed/NCBI View Article : Google Scholar | |
|
Ernst C, Odom DT and Kutter C: The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity. Nat Commun. 8(1411)2017.PubMed/NCBI View Article : Google Scholar | |
|
Ho S, Theurkauf W and Rice N: piRNA-guided transposon silencing and response to stress in drosophila germline. Viruses. 16(714)2024.PubMed/NCBI View Article : Google Scholar | |
|
Siomi MC, Sato K, Pezic D and Aravin AA: PIWI-interacting small RNAs: The vanguard of genome defence. Nat Rev Mol Cell Biol. 12:246–258. 2011.PubMed/NCBI View Article : Google Scholar | |
|
Nong S, Han X, Xiang Y, Qian Y, Wei Y, Zhang T, Tian K, Shen K, Yang J and Ma X: Metabolic reprogramming in cancer: Mechanisms and therapeutics. MedComm (2020). 4(e218)2023.PubMed/NCBI View Article : Google Scholar | |
|
Wei Z, Liu X, Cheng C, Yu W and Yi P: Metabolism of amino acids in cancer. Front Cell Dev Biol. 8(603837)2021.PubMed/NCBI View Article : Google Scholar | |
|
Sauer SW: Biochemistry and bioenergetics of glutaryl-CoA dehydrogenase deficiency. J Inherit Metab Dis. 30:673–680. 2007.PubMed/NCBI View Article : Google Scholar | |
|
Lao Y, Cui X, Xu Z, Yan H, Zhang Z, Zhang Z, Geng L, Li B, Lu Y, Guan Q, et al: Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma. J Hepatol: S0168-8278(24)00369-6, 2024 (Epub ahead of print). | |
|
Jiang LQ, de Castro Barbosa T, Massart J, Deshmukh AS, Löfgren L, Duque-Guimaraes DE, Ozilgen A, Osler ME, Chibalin AV and Zierath JR: Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics. Am J Physiol Endocrinol Metab. 310:E51–E60. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Ren Y, Liu SF, Nie L, Cai SY and Chen J: Involvement of ayu NOD2 in NF-κB and MAPK signaling pathways: Insights into functional conservation of NOD2 in antibacterial innate immunity. Zool Res. 40:77–88. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Lv J, Liu Y, Mo S, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, et al: Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol. 24:364–372. 2022.PubMed/NCBI View Article : Google Scholar | |
|
Ritter A and Kreis NN: Microtubule dynamics and cancer. Cancers (Basel). 14(4368)2022.PubMed/NCBI View Article : Google Scholar | |
|
Robinson CM, Talty A, Logue SE, Mnich K, Gorman AM and Samali A: An emerging role for the unfolded protein response in pancreatic cancer. Cancers (Basel). 13(261)2021.PubMed/NCBI View Article : Google Scholar | |
|
Yang X, Khosravi-Far R, Chang HY and Baltimore D: Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 89:1067–1076. 1997.PubMed/NCBI View Article : Google Scholar | |
|
Kanchanawong P and Calderwood DA: Organization, dynamics and mechanoregulation of integrin-mediated cell-ECM adhesions. Nat Rev Mol Cell Biol. 24:142–161. 2023.PubMed/NCBI View Article : Google Scholar | |
|
Israeli-Rosenberg S, Chen C, Li R, Deussen DN, Niesman IR, Okada H, Patel HH, Roth DM and Ross RS: Caveolin modulates integrin function and mechanical activation in the cardiomyocyte. FASEB J. 29:374–384. 2015.PubMed/NCBI View Article : Google Scholar | |
|
Velez DO, Ranamukhaarachchi SK, Kumar A, Modi RN, Lim EW, Engler AJ, Metallo CM and Fraley SI: 3D collagen architecture regulates cell adhesion through degradability, thereby controlling metabolic and oxidative stress. Integr Biol (Camb). 11:221–234. 2019.PubMed/NCBI View Article : Google Scholar | |
|
Le Cosquer G, Maulat C, Bournet B, Cordelier P, Buscail E and Buscail L: Pancreatic cancer in chronic pancreatitis: Pathogenesis and diagnostic approach. Cancers (Basel). 15(761)2023.PubMed/NCBI View Article : Google Scholar | |
|
Ahmad S, Ahmed MM, Hasan PMZ, Sharma A, Bilgrami AL, Manda K, Ishrat R and Syed MA: Identification and validation of potential miRNAs, as biomarkers for sepsis and associated lung injury: A network-based approach. Genes (Basel). 11(1327)2020.PubMed/NCBI View Article : Google Scholar | |
|
Alrashoudi RH, Crane IJ, Wilson HM, Al-Alwan M and Alajez NM: Gene expression data analysis identifies multiple deregulated pathways in patients with asthma. Biosci Rep. 38(BSR20180548)2018.PubMed/NCBI View Article : Google Scholar | |
|
Chen H, Chew G, Devapragash N, Loh JZ, Huang KY, Guo J, Liu S, Tan ELS, Chen S, Tee NGZ, et al: The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis. Nat Commun. 13(7375)2022.PubMed/NCBI View Article : Google Scholar | |
|
Clark CR, Maile M, Blaney P, Hellweg SR, Strauss A, Durose W, Priya S, Habicht J, Burns MB, Blekhman R, et al: Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene. Sci Rep. 8(15327)2018.PubMed/NCBI View Article : Google Scholar | |
|
Coenen DM, Heinzmann ACA, Oggero S, Albers HJ, Nagy M, Hagué P, Kuijpers MJE, Vanderwinden JM, van der Meer AD, Perretti M, et al: Inhibition of phosphodiesterase 3A by cilostazol dampens proinflammatory platelet functions. Cells. 10(1998)2021.PubMed/NCBI View Article : Google Scholar | |
|
Di Stefano A, Gnemmi I, Rosani U, Maniscalco M, D'Anna SE, Brun P, Carriero V, Bertolini F, Balbi B and Ricciardolo FLM: Upregulation of notch signaling and cell-differentiation inhibitory transcription factors in stable chronic obstructive pulmonary disease patients. Int J Mol Sci. 25(3287)2024.PubMed/NCBI View Article : Google Scholar | |
|
Ghanem MH, Shih AJ, Vashistha H, Coke LN, Li W, Kim SJ, Simpfendorfer KR and Gregersen PK: Investigations into SCAMP5, a candidate lupus risk gene expressed in plasmacytoid dendritic cells. Lupus Sci Med. 8(e000567)2021.PubMed/NCBI View Article : Google Scholar | |
|
Kim YS, Park HJ, Park JH, Hong EJ, Jang GY, Jung ID, Han HD, Lee SH, Vo MC, Lee JJ, et al: A novel function of API5 (apoptosis inhibitor 5), TLR4-dependent activation of antigen presenting cells. Oncoimmunology. 7(e1472187)2018.PubMed/NCBI View Article : Google Scholar | |
|
Kraja AT, Chasman DI, North KE, Reiner AP, Yanek LR, Kilpeläinen TO, Smith JA, Dehghan A, Dupuis J, Johnson AD, et al: Pleiotropic genes for metabolic syndrome and inflammation. Mol Genet Metab. 112:317–338. 2014.PubMed/NCBI View Article : Google Scholar | |
|
Li T, Qiu J, Jia T, Liang Y, Zhang K, Yan W, Hou Z, Yang S, Liu L, Xiong W, et al: G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction. Genes Dis. 9:1701–1715. 2022.PubMed/NCBI View Article : Google Scholar | |
|
Lin YC, Chang PC, Hueng DY, Huang SM and Li YF: Decoding the prognostic significance of integrator complex subunit 9 (INTS9) in glioma: links to TP53 mutations, E2F signaling, and inflammatory microenvironments. Cancer Cell Int. 23(154)2023.PubMed/NCBI View Article : Google Scholar | |
|
Mc Fie M, Koneva L, Collins I, Coveney CR, Clube AM, Chanalaris A, Vincent TL, Bezbradica JS, Sansom SN and Wann AKT: Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia. J Cell Sci. 133(jcs239871)2020.PubMed/NCBI View Article : Google Scholar | |
|
Patankar M, Li M, Khalatbari A, Castle JD, Hu L, Zhang C and Shaker A: Inflammatory and proliferative pathway activation in human esophageal myofibroblasts treated with acidic bile salts. Int J Mol Sci. 23(10371)2022.PubMed/NCBI View Article : Google Scholar | |
|
Ramachandran R, Hyun E, Zhao L, Lapointe TK, Chapman K, Hirota CL, Ghosh S, McKemy DD, Vergnolle N, Beck PL, et al: TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proc Natl Acad Sci USA. 110:7476–7481. 2013.PubMed/NCBI View Article : Google Scholar | |
|
Tian CJ, Zhang JH, Liu J, Ma Z and Zhen Z: Ryanodine receptor and immune-related molecules in diabetic cardiomyopathy. ESC Heart Fail. 8:2637–2646. 2021.PubMed/NCBI View Article : Google Scholar | |
|
Weng HR, Taing K, Chen L and Penney A: EZH2 methyltransferase regulates neuroinflammation and neuropathic pain. Cells. 12(1058)2023.PubMed/NCBI View Article : Google Scholar | |
|
Asadi MR, Rahmanpour D, Moslehian MS, Sabaie H, Hassani M, Ghafouri-Fard S, Taheri M and Rezazadeh M: Stress granules involved in formation, progression and metastasis of cancer: A scoping review. Front Cell Dev Biol. 9(745394)2021.PubMed/NCBI View Article : Google Scholar | |
|
Federico A, Rienzo M, Abbondanza C, Costa V, Ciccodicola A and Casamassimi A: Pan-cancer mutational and transcriptional analysis of the integrator complex. Int J Mol Sci. 18(936)2017.PubMed/NCBI View Article : Google Scholar | |
|
Jiang H, Wang G, Gu J, Xiao Y, Wang P, Huang X, Sha H, Wang Z and Ma Q: Resveratrol inhibits the expression of RYR2 and is a potential treatment for pancreatic cancer. Naunyn Schmiedebergs Arch Pharmacol. 395:315–324. 2022.PubMed/NCBI View Article : Google Scholar | |
|
Jo EH, Kim MY, Lee HJ and Park HS: Ubiquitin E3 ligases in cancer: somatic mutation and amplification. BMB Rep. 56:265–274. 2023.PubMed/NCBI View Article : Google Scholar | |
|
Khan NA, Garg AD, Agostinis P and Swinnen JV: Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway. Oncotarget. 9:3507–3518. 2018.PubMed/NCBI View Article : Google Scholar | |
|
Koci L, Chlebova K, Hyzdalova M, Hofmanova J, Jira M, Kysela P, Kozubik A, Kala Z and Krejci P: Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo. Oncol Lett. 3:913–916. 2012.PubMed/NCBI View Article : Google Scholar | |
|
Kumazoe M, Takai M, Hiroi S, Takeuchi C, Yamanouchi M, Nojiri T, Onda H, Bae J, Huang Y, Takamatsu K, et al: PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma. Sci Rep. 7(1917)2017.PubMed/NCBI View Article : Google Scholar | |
|
Li Q, Lei C, Lu C, Wang J, Gao M and Gao W: LINC01232 exerts oncogenic activities in pancreatic adenocarcinoma via regulation of TM9SF2. Cell Death Dis. 10(698)2019.PubMed/NCBI View Article : Google Scholar | |
|
Mao F, Duan H, Allamyradov A, Xin Z, Du Y, Wang X, Xu P, Li Z, Qian J and Yao J: Expression and prognostic analyses of SCAMPs in pancreatic adenocarcinoma. Aging (Albany NY). 13:4096–4114. 2021.PubMed/NCBI View Article : Google Scholar | |
|
Miao Z, Ali A, Hu L, Zhao F, Yin C, Chen C, Yang T and Qian A: Microtubule actin cross-linking factor 1, a novel potential target in cancer. Cancer Sci. 108:1953–1958. 2017.PubMed/NCBI View Article : Google Scholar | |
|
Paradise BD, Barham W and Fernandez-Zapico ME: Targeting epigenetic aberrations in pancreatic cancer, a new path to improve patient outcomes? Cancers (Basel). 10(128)2018.PubMed/NCBI View Article : Google Scholar | |
|
Witkiewicz AK, Balaji U, Eslinger C, McMillan E, Conway W, Posner B, Mills GB, O'Reilly EM and Knudsen ES: Integrated patient-derived models delineate individualized therapeutic vulnerabilities of pancreatic cancer. Cell Rep. 16:2017–2031. 2016.PubMed/NCBI View Article : Google Scholar | |
|
Yee NS, Brown RD, Lee MS, Zhou W, Jensen C, Gerke H and Yee RK: TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: Potential role of TRPM8 as a biomarker and target. Cancer Biol Ther. 13:592–599. 2012.PubMed/NCBI View Article : Google Scholar |
