Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas
Retraction in: /etm/7/6/1803
- Authors:
- Published online on: October 10, 2013 https://doi.org/10.3892/etm.2013.1340
- Pages: 1380-1384
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Abstract
The aim of this study was to investigate the expression and significance of a disintegrin and metalloproteinase 10 (ADAM10), epidermal growth factor receptor (EGFR) and E‑cadherin protein in hepatocellular carcinomas. The expression levels of ADAM10, EGFR and E‑cadherin were analyzed in 40 cases of hepatocellular carcinoma using immunohistochemistry and quantitative polymerase chain reaction (qPCR). The expression levels of ADAM10, EGFR and E-cadherin were significantly correlated with portal vein thrombosis, intrahepatic metastasis, differentiation degree and tumor size (P<0.05). In hepatocellular carcinoma, the expression levels of ADAM10 and EGFR were increased and the levels of E‑cadherin were decreased compared with those in the adjacent tissues. The elevated expression levels of ADAM10 and EGFR may be associated with the malignancy of the tumors. E‑cadherin expression is negatively correlated with the degree of malignancy. The detection of ADAM10, EGFR and E‑cadherin expression levels may contribute to an understanding of the oncogenesis and development of hepatocellular carcinomas.
