Open Access

Efficacy research of salazosulfamide in ankylosing spondylitis and NAT1 gene polymorphism

  • Authors:
    • Xiu-Fen Ma
    • Xiao-Dong Wang
    • Run-Rong Liu
    • Qing-Xia Luan
  • View Affiliations

  • Published online on: July 27, 2017     https://doi.org/10.3892/etm.2017.4844
  • Pages: 2999-3003
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of this study was to explore the correlation of salazosulfamide efficacy on ankylosing spondylitis and N-acetyltransferase 1 (NAT1) gene polymorphism. Thirty-two patients with ankylosing spondylitis were recruited in the experimental group and 36 normal individuals were recruited to the control group. The experimental group received 8.0 mg of salazosulfamide (MTX) per week and the control group received isodose of normal saline. Twenty-six patients in the experimental group responded to the salazosulfamide treatment and 6 did not show response. Morning stiffness time of patients in the experimental group who responded to salazosulfamide was significantly lower than that of patients with no reaction to salazosulfamide, and similar to patients in the control group. The average tender joint count of patients in the experimental group that responded to salazosulfamide was lower than in patients with no response to treatment, and similar to patients in the control group. NAT1 gene sequencing determined that the patients sensitive to salazosulfamide treatment manifested as AA/AG at 263 locus, whereas patients not sensitive to salazosulfamide were GG. NAT1 expression was comparable between the different genotypes at the mRNA level. However, there was a significant difference of NAT1 protein between groups. Overall, salazosulfamide demonstrates curative activity for ankylosing spondylitis and we believe that NAT1 AA/GG genotype at 263 locus can promote salazosulfamide effectiveness on ankylosing spondylitis.

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October-2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ma X, Wang X, Liu R and Luan Q: Efficacy research of salazosulfamide in ankylosing spondylitis and NAT1 gene polymorphism. Exp Ther Med 14: 2999-3003, 2017.
APA
Ma, X., Wang, X., Liu, R., & Luan, Q. (2017). Efficacy research of salazosulfamide in ankylosing spondylitis and NAT1 gene polymorphism. Experimental and Therapeutic Medicine, 14, 2999-3003. https://doi.org/10.3892/etm.2017.4844
MLA
Ma, X., Wang, X., Liu, R., Luan, Q."Efficacy research of salazosulfamide in ankylosing spondylitis and NAT1 gene polymorphism". Experimental and Therapeutic Medicine 14.4 (2017): 2999-3003.
Chicago
Ma, X., Wang, X., Liu, R., Luan, Q."Efficacy research of salazosulfamide in ankylosing spondylitis and NAT1 gene polymorphism". Experimental and Therapeutic Medicine 14, no. 4 (2017): 2999-3003. https://doi.org/10.3892/etm.2017.4844