Open Access

Effects of puerarin combined with conventional therapy on ischemic stroke

  • Authors:
    • Min Yuan
    • Guijiang Liu
    • Xiuqi Zheng
    • Pei Li
    • Jinghua Liu
    • Sujie Wang
    • Yibin Cao
  • View Affiliations

  • Published online on: August 11, 2017     https://doi.org/10.3892/etm.2017.4922
  • Pages:2943-2946
  • Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

This study evaluated the use of conventional therapy combined with puerarin on ischemic stroke. Eighty patients with ischemic stroke admitted to Tangshan Gongren Hospital from March 2014 to September 2015 were randomly divided into two groups. The control group was treated with conventional therapy. The observation group was treated with an additional puerarin injection of 400 mg/day. The patients in both groups were examined for clinical neurological signs and symptoms. The levels of biochemical markers as well as changes in hemorheology were measured after the intervention and compared among the groups. Our results indicate that the language expression was significantly better in the observation group after the intervention (p<0.05). Additionally, the aphasia quotient was higher (p<0.05), the neurological deficit score was lower (p<0.05), and the functional ability score was higher (p<0.05). The plasma S-100B and NSE levels were lower (p<0.05), the whole blood viscosity and plasma viscosity were lower (p<0.05), and the levels of corticotropin-releasing hormone, corticotropin, cortisol, adrenaline and norepinephrine were lower (p<0.05). Our findings led to the conclusion that the use of puerarin can effectively improve the language function, reduce neurological damage, reduce blood viscosity, reduce stress response and improve quality of life.

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October 2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Yuan, M., Liu, G., Zheng, X., Li, P., Liu, J., Wang, S., & Cao, Y. (2017). Effects of puerarin combined with conventional therapy on ischemic stroke. Experimental and Therapeutic Medicine, 14, 2943-2946. https://doi.org/10.3892/etm.2017.4922
MLA
Yuan, M., Liu, G., Zheng, X., Li, P., Liu, J., Wang, S., Cao, Y."Effects of puerarin combined with conventional therapy on ischemic stroke". Experimental and Therapeutic Medicine 14.4 (2017): 2943-2946.
Chicago
Yuan, M., Liu, G., Zheng, X., Li, P., Liu, J., Wang, S., Cao, Y."Effects of puerarin combined with conventional therapy on ischemic stroke". Experimental and Therapeutic Medicine 14, no. 4 (2017): 2943-2946. https://doi.org/10.3892/etm.2017.4922