Open Access

Tumoricidal activities of pterostilbene depend upon destabilizing the MTA1-NuRD complex and enhancing P53 acetylation in hepatocellular carcinoma

  • Authors:
    • Yu‑Yuan Qian
    • Zhi‑Su Liu
    • Ding‑Yu Pan
    • Kun Li
  • View Affiliations

  • Published online on: August 11, 2017     https://doi.org/10.3892/etm.2017.4923
  • Pages:3098-3104
  • Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to assess the tumoricidal effect of metastasis‑associated protein 1 (MTA1) induced by pterostilbene (PTER) in hepatocellular carcinoma (HCC). The SMMC‑7721 hepatoma cell line was treated with PTER. Following treatment, the mRNA transcript abundance of MTA1 was measured using quantitative polymerase chain reaction. Additionally, cell viability was determined using an MTT assay, and protein expression was measured through western blotting. Cell invasion, motility and apoptosis, as well as the cell cycle, were also investigated. Following PTER treatment, MTA1, histone deacetylase (HDAC) 1 and HDAC2 were downregulated, whereas the ratio of acetyl‑p53 to total p53 was increased in HCC cells. Cell viability decreased as the PTER dose increased. MTA1 may be associated with proliferation, motility, invasion and metastasis in HCC cells. PTER appeared to repress cell proliferation, trigger apoptosis, induce cell cycle arrest, and inhibit motility and invasion via MTA1 in human liver cancer cells. The results of the present study demonstrated that PTER can downregulate the MTA1‑nucleosome remodeling and deacetylase complex, and enhance p53 acetylation to inhibit the growth of tumor cells in HCC.

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October 2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Qian, Y., Liu, Z., Pan, D., & Li, K. (2017). Tumoricidal activities of pterostilbene depend upon destabilizing the MTA1-NuRD complex and enhancing P53 acetylation in hepatocellular carcinoma. Experimental and Therapeutic Medicine, 14, 3098-3104. https://doi.org/10.3892/etm.2017.4923
MLA
Qian, Y., Liu, Z., Pan, D., Li, K."Tumoricidal activities of pterostilbene depend upon destabilizing the MTA1-NuRD complex and enhancing P53 acetylation in hepatocellular carcinoma". Experimental and Therapeutic Medicine 14.4 (2017): 3098-3104.
Chicago
Qian, Y., Liu, Z., Pan, D., Li, K."Tumoricidal activities of pterostilbene depend upon destabilizing the MTA1-NuRD complex and enhancing P53 acetylation in hepatocellular carcinoma". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3098-3104. https://doi.org/10.3892/etm.2017.4923