IL‑32γ promotes integrin αvβ6 expression through the activation of NF‑κB in HSCs

  • Authors:
    • Hongcan Liu
    • Xingfei Pan
    • Hong Cao
    • Xin Shu
    • Haixia Sun
    • Jianxi Lu
    • Jiayin Liang
    • Ka Zhang
    • Fengqin Zhu
    • Gang Li
    • Qi Zhang
  • View Affiliations

  • Published online on: August 17, 2017     https://doi.org/10.3892/etm.2017.4956
  • Pages: 3880-3886
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Abstract

Hepatic stellate cell (HSC) activation is important in the pathogenesis of liver fibrosis. However, the molecular mechanism of HSC activation is not completely understood. In the present study, it was demonstrated that interleukin‑32γ (IL‑32γ) is capable of enhancing intefgrin αvβ6 expression by inducing integrin αvβ6 promoter activity in a dose‑dependent manner in HSCs. Furthermore, it was determined that nuclear factor κB (NF‑κB) activation is required for IL‑32γ‑induced integrin αvβ6 expression. Increased integrin αvβ6 expression is then able to activate HSCs. These results indicate that NF‑κB activation is required for IL‑32γ to induce integrin αvβ6 expression and consequently promote HSC activation. Therefore, IL‑32γ activates HSCs and therefore may be associated with hepatic fibrogenesis. These results may enable the development of novel effective strategies to treat hepatic fibrosis.

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October-2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu H, Pan X, Cao H, Shu X, Sun H, Lu J, Liang J, Zhang K, Zhu F, Li G, Li G, et al: IL‑32γ promotes integrin αvβ6 expression through the activation of NF‑κB in HSCs. Exp Ther Med 14: 3880-3886, 2017
APA
Liu, H., Pan, X., Cao, H., Shu, X., Sun, H., Lu, J. ... Zhang, Q. (2017). IL‑32γ promotes integrin αvβ6 expression through the activation of NF‑κB in HSCs. Experimental and Therapeutic Medicine, 14, 3880-3886. https://doi.org/10.3892/etm.2017.4956
MLA
Liu, H., Pan, X., Cao, H., Shu, X., Sun, H., Lu, J., Liang, J., Zhang, K., Zhu, F., Li, G., Zhang, Q."IL‑32γ promotes integrin αvβ6 expression through the activation of NF‑κB in HSCs". Experimental and Therapeutic Medicine 14.4 (2017): 3880-3886.
Chicago
Liu, H., Pan, X., Cao, H., Shu, X., Sun, H., Lu, J., Liang, J., Zhang, K., Zhu, F., Li, G., Zhang, Q."IL‑32γ promotes integrin αvβ6 expression through the activation of NF‑κB in HSCs". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3880-3886. https://doi.org/10.3892/etm.2017.4956