Flexible ureteroscopic holmium laser lithotripsy with PolyScope for senile patients with renal calculi
- Authors:
- Published online on: June 28, 2018 https://doi.org/10.3892/etm.2018.6369
- Pages: 1723-1728
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Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Abstract
Introduction
The incidence of kidney stones has been increasing over the years (1). What's more, the incidence rate of kidney stone disease increases with aging (2,3). Senile urolithiasis belongs to complex renal calculi disease, since the patients usually have many comorbidities, such as chronic heart, lung, liver, kidney disfuction or severe urinary tract infection (4), adding extra difficulty to clinical treatment. Patients with kidney stones usually presented with hydronephrosis, back pain and fever and other symptoms, and need active and effective surgical treatment (5). Safe, timely and effective treatment of kidney stones can reduce serious complications such as kidney failure in senile patients, and significantly improve quality of life. This has brought urologists new requirements and challenges.
Nowadays, operation methods to treat kidney stones include open surgery, extracorporeal shock wave lithotripsy (ESWL), percutaneous nephroscope lithotripsy (PCNL) and ureteroscopic lithotripsy (URL). Traditional open surgery has lots of complications with considerate influence to renal function. The elderly with low body reserve capacity, reduced tolerance to surgery, slow postoperative recovery may develop many complications as the result of prolonged bed rest after open surgery (6,7). In the past, limited by the hardware, kidney stones were treated by ESWL or PCNL with limited safety and efficacy (8). In recent years, with the development of flexible ureteroscope technical and auxiliary equipment (9), the flexible ureteroscopy (fURS) combined with holium laser lithotripsy is becoming mature and has gradually become an ideal choice for kidney stone. Compared with the ESWL or PCNL, especially in the treatment of senile kidney stone, its advantages are higher stone-free rate (SFR) and safer operation and fewer intraoperative and postoperative complications (10,11). PolyScope is a novel removable modular flexible ureteroscope manufactured by Polydiagnost GmbH (Pfaffenhofen, Germany) (Fig. 1). The core components are the independent, optical, imaging modules, convenient to assemble or disassemble. The optical system has a soft yet tough synthetic metal wire net wrapped around for protection. The outer casing of the flexible ureteroscope is replaceable at a relatively low price. This eradicates the risk of cross-infection between operations, and enables the ureteroscope be used in successive procedures. The main advantage of PolyScope is its convenience for the replacement of consumable components to reduce the maintenance costs (12). We had already evaluated PolyScope against its conventional counterpart earlier (13). Yet its safety and effectiveness in treating senile patients, a special group of patients with urolithiasis, has not been reported so far. In the present study, from December 2013 to December 2016, 157 cases of senile patients with kidney stones were treated with PolyScope in Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine (Shanghai, China). The results were satisfactory and are reported in the following sections.
Patients and methods
Patient characteristics
This is a retrospective study. A total of 157 patients (88 males and 69 females, aged from 60 to 82 years, mean age 69.1±6.1 years old) with kidney stone who were admitted to Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine from December 2013 to December 2016 were recruited for this study. The body mass index (BMI) ranged from 16.3 to 32.5 and the mean BMI was 23.4±2.9. Nineteen patients had I degree of obesity (25≤ BMI <30) and 5 patients had with II degree of obesity (BMI ≥30). A total of 86 patients presented with hypertension, 26 with cardiovascular disease, 21 with anticoagulants or antiplatelet medications, 15 with diabetes, 38 with hydronephrosis, 13 with creatinine abnormality, 27 with COPD, 2 with horseshoe kidney, 2 with congenital solitary kidney. Thirty-two of the patients had been hospitalized and treated with ESWL, 17 with PCNL, 12 with fURS. Nineteen patients had previously had an indwelling double-J stent placed with ureteroscopic guidance in other hospital. All patients had been diagnosed by plain film of kidney-ureter-bladder (KUB) intravenous urography (IVU) and computed tomography (CT). In addition, 149 patients exhibited one-sided calculi, whereas 8 patients exhibited two-sided calculi. The total number of renal calculi was 245 and mean number of each side was 1.5±1.0, including 61 renal pelvic calculi, 43 upper calyceal calculi, 55 middle calyceal calculi, 86 lower calyceal calculi. Digital surface area of each patient ranged from 55.8 to 478.3 mm2 (mean, 154.6±57.7 mm2). All patients' middle segment urine samples were collected for the germiculture and sensitivity test. The result was that 148 cases presented with no bacterial growth, 7 with Escherichia coli, 2 with Proteus. The information of 332 adult patients (185 males and 147 females, aged from 18 to 59 years, mean age 41.5±9.9 years old) of the same period, who were also treated with PolyScope, were also analyzed and compared with that of the senile patients (Table I). The two groups had difference in comorbidity rate, including hypertension (P<0.01), cardiovascular disease (P<0.05), anti-coagulation (P<0.05) and COPD (P<0.01). Other criteria were statistically similar between two groups.
Operational parameters
All patients were placed under spinal or general anesthesia (153 spinal anesthesia, 4 general anesthesia) in a lithotomy position with head tilted down. After location of the ureter, a zebra guide wire was inserted and a Wolf F8/9.8 rigid ureteroscope (Richard Wolf GmbH, Knittlingen, Germany) was placed into the ureter to reach the level of the pelvis. Following the removal of the rigid ureteroscope, a Cook F12/14 ureteral access sheath (UAS; Cook Medical, Inc., Bloomington, IN, USA) was positioned along the guide wire, as close to the level of the uretero-pelvic junction as possible, then PolyScope was inserted into the pelvis through the UAS. The power of the 220 mm holmium laser lithotripsy was set at 1.0–2.0 J. The ‘nibble’ approach was used to break and crumble the stones into fine granules measuring 2–3 mm. Some stones with the diameter of 4–5 mm were removed with a stone basket, while some lower calyceal stones were translocated with the basket from the lower to the upper or middle calyx for improving the efficiency of lithotripsy and also for protection of the optical fiber.
A F6 double-J stent was typically indwelled for 4 weeks following the surgery and a Foley urethral catheter was indwelled for 1–2 days. Plain film of KUB was performed 1 day subsequent to the surgery in order to determine the result of the lithotripsy and the position of the double-J stent. Postoperative follow-up to the hospital in a month was required. KUB or CT was performed and double-J stent removed.
Ethics approval and consent to participate
The Ethics Committee of Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine has approved the study and permitted the waiver of written informed consent from patients. The study protocol is also in accordance with the Declaration of Helsinki.
Statistical analysis
The data were analyzed using the SPSS 17.0 (SPSS, Inc., Chicago, IL, USA). Continuous data were presented as mean ± standard deviation, and compared using Student's t-test. For categorical data, the values outside the brackets are the absolute patient number and the values inside the brackets are the percentage, and were compared using Chi-square or Fisher's exact test, and P<0.05 was considered statistically significant. All tests were performed as a 2-tailed test.
Results
Lithotripsy was performed successfully in all 157 patients. 139 patients underwent one-stage lithotripsy and 18 patients two-stage. The duration of the surgery ranged from 37 to 124 min (mean duration, 54.6±13.2 min). Little bleeding was recorded and no ureteral perforation or damage was encountered. A total of 24 patients presented with fever following the surgery, their body temperature all returned to normal following anti-inflammatory treatment with either empirical antibiotics or according to the susceptibility results of preoperative urine culture. Three patients' urine color remained pink in one week after surgery, yet all became normal following the use of hemostatic drugs. The SFR was 81.5% for one-stage lithotripsy and 89.2% for two-stage lithotripsy. The remaining 17 patients had postoperative residual stones (diameter ranged from 4 to 5 mm, lower calyceal calculi) and did not take further ESWL treatment. The postoperative follow-up period was 3–24 months. All symptoms of back pain and abdominal pain were eliminated or greatly relieved and hydronephrosis was improved markedly according to KUB or CT. The operation data of the senile group was compared to that of the non-senile group. Operative time and SFR were similar between two groups, so was the hospitalization length and complication rates (Table I).
Within the senile group, between the patients with and without fever, the diabetes mellitus ratio (P<0.05), hydronephrosis ratio (P<0.05) and urinary tract infection ratio (P<0.01), was significantly higher, and the operative time was also significantly longer (P<0.01) (Table II).
Discussion
The world's elderly population is growing at a rapid rate. In 2015, people aged ≥65 years accounted for 8.5% of the world's population, and this proportion is expected to rise to 17% by the year 2050 (14). Chronic disease, such as hypertension, diabetes and cardiovascular disease, has high prevalence among the elderly. And they are also weaker than the young in cardiopulmonary function, immunity, restorability and so on. On the other hand, percentage of obese patients in the elderly is also increasing gradually with the rising of the living standards. Now a days, the selection of treatment for renal calculi with which kind of minimally invasive method become a prominent question. ESWL or PCNL used to be the choice for the majority of senile patients with kidney stones. ESWL is a kind of non-invasive treatment exhibiting desirable efficacy and safety. However, its SFR is influenced by many factors, such as the size, the location and the texture of stone, the obesity degree of patient and so on. Also, larger stones are often too large to be shattered and require several times of treatment to reach the target size. The reported clearance rate of ESWL for lower calyceal stone is 25–85% (15). From our experience, it is often very difficult, if not impossible, for the lower calyceal stone to be cleared by ESWL. And the SFR of ESWL for obese patients is also greatly reduced (16). It is reported that, in comparison with the non-senile group treated by ESWL, there was no significant difference in SFR in senile group (17). However, the incidence of complications was higher in senile group than that in non-senile group. Compared with ESWL, the SFR of PCNL is higher, especially for large stones (18). PCNL is an invasive method which is not suitable for relatively weak senile patient with coagulation disorders or poor heart and lung function. The hospitalization time of PCNL is also longer than that of ESWL and URL (19,20). The difficulty of puncture of PCNL in obese patients increases and effect of operation decreases. Berkan used to score and grade on senile patients with kidney stone before PCNL according to Charlson Comorbidity Index. He found that the incidence of complications rose with the score increasing and suggested to take conservative treatment instead of operation for those asymptomatic kidney stone patients with high scores (21).
The technology of fURS has developed rapidly since it was reported by Bagley in 1987 for the first time. fURS has higher SFR for lower calyceal calculi and stone larger than 1 cm compared with ESWL (22). fURS rarely cause severe arrhythmia which may be induced by ESWL in senile patients with basic rhythm problems and renal colic caused by gravels clogging the ureter after ESWL in some patients (23). fURS has comparable SFR to PCNL, however it has lots of advantages, such as fewer contraindications with a wider range of application, smaller trauma without puncture, less blood loss without potential demand for blood transfusion, shorter hospital stay with quicker recovery (24). Since it is unnecessary to puncture, there are no special requirements for the patient's body shape in fURS. Its therapeutic effect in obese patient is similar to that in patient with normal BMI (25). In our study, all obese patients, including 19 patients with I degree of obesity (25≤ BMI <30) and 5 patients with II degree of obesity (BMI ≥30), underwent successful operation and there was no significant difference in operation time with patients with normal BMI. Although some patients had poor cardiopulmonary function, there was no relevant accident or complication due to less influence of spinal anesthesia on circulatory/respiratory system compared with general anesthesia.
PolyScope has the advantages of simple operation, clear visibility and a reliable efficacy (12,26). However, the most obvious weakness of this type of flexible ureteroscope is its capability of being able to flex in just one direction. In an empty working channel, the lens barrel has been demonstrated to bend at an angle of 265; the bending angle is reduced by 10 and 2% respectively, following the insertion of a 3.0F stone basket or a 200 µm laser fiber (12). Before the insertion of the modular flexible ureteroscope, it was necessary for the UAS to be positioned near the level of the ureteropelvic junction. This aids to reduce the renal pelvic pressure during surgery, serve as protection for the lens barrel and provide a convenient access for the extraction of stone fragments (26). In case of ureteral stenosis, it is necessary to indwell an F6 double-J stent for a second operation. It is also necessary for the end of the flexible ureteroscope to be maintained in a stretched state during the insertion of the 220 µm holmium laser optical fiber in order to avoid damaging the work channel of the lens barrel and the kidney. When losing the sense of direction in the intracavity, just take out the ureteroscope for reorientation.
For senile patients with kidney stones, the following tips need to be remembered: i) As the majority of senile patients have commodities of hypertension and/or diabetes, their blood pressure and blood sugar need to be monitored closely with systolic pressure under 140–160 mmHg and blood sugar between 6–10 mmol/l. ii) Operation time need to be controlled strictly, as the immune system of the senile is relatively weak. The plan of stage operation should be made for those patients with large stone. Avoid long-time lithotripsy might reduce the probability of postoperative fever. It is necessary to do the germiculture and sensitivity test before operation and take postoperative prophylactic antibiotic therapy. iii) As many senile patients take antiplatelet drugs or anticoagulant drugs like aspirin and clopidogrel, they need to stop taking the drug for one week to restore their coagulation function. Timely restoration of the use of antiplatelet or anticoagulant agents after the surgery according to the urine color is also necessary. Usually, there is no problem to restore their use 3 days after operation. The duration should be longer if the urine is still red. In particular, urologists should be cautious with the patients with diabetes for many years. Operations should be gentle and meticulous to avoid ureteral mucosa injury, hemorrhage and postoperative infection.
Our experience and suggestions are as follows: i) In consideration of the relatively weak immunity of senile patients, the use of PolyScope can avoid cross infection as it is disposable. ii) The 8F diameter lens barrel means the gap between lens barrel and UAS in the PolyScope is larger than that in the traditional fURS with 8.5F diameter lens barrel. The large gap brings many advantages, such as sufficient drainage which can reduce intrapelvic pressure effectively, great vortex effects which can accelerate stone extraction and decreased fraction between the lens barrel and the stone which can reduce the damage of lens barrel. iii) We recommend upgrading the PolyScope by adding a ‘handle’ just like the one used in SMP (27), consisting of a straight and an oblique bifurcated tube. The straight tube can be contiguous with the access sheath and has a receptacle for a silicone or rubber cap at the proximal end. A longitudinal slit can be designed along the axis of the oblique tube to be used as a pressure vent through which the negative aspiration pressure can be adjusted. The end of the oblique tube can be connected to a continuous negative pressure aspirator through clear flexible tubing with the same or larger lumen. A specimen collection bottle can be added between the handle and the aspirator to facilitate stone fragment collection.
Although the quality of fURS has been greatly improved in recent years, it is still not endurable enough to deal with the numerous patents with urolithiasis, especially in a country with a huge population like China. In a multi-center clinical trial, Knudsen et al found that flexible ureteroscope required fixing after its use in 5.3–18 patients (28–30). In addition, according to statistics from multiple articles, the main reasons for repair were the decreased capacity of active bending, the decreased image quality caused by fiber cuts and the sparking of laser in lens barrel (28–32). It is necessary to protect the flexible ureteroscope during operation. The indwelling UAS provides a convenient access point and protection for the lens barrel, benefits for the extraction of stone fragments, also helps to reduce the renal pelvic pressure during surgery which can reduce the intraoperative absorption of lavage fluid and the incidence of postoperative fever and bacteremia (32,33). It is of great significance to adjust the position and curvature of lens barrel according to the ureteral walk, kidney shape, calculi position and calculi size by carefully reading preoperative CTU/IVU (26). The protection of flexible ureteroscope is particularly important in the treatment of lower calyceal calculi as in such circumstance, the flexible ureteroscope needs to maintain a relatively large angle bending state for a long time. In our study, we all take measures of adjusting patients' position and trying to translocate lower calyceal calculi with the stone basket from the lower to the upper or middle calyx to improve the efficiency of the stone breaking. On the one hand, this method can prevent calculi running to the place that the flexible ureteroscope can't reach; on the other hand, it can extend the life of the flexible ureteroscope and reduce equipment losses and maintenance costs by reducing the time of maximal bending.
The removable modular flexible ureteroscopic management with holmium laser lithotripsy has high SFR in senile patients with kidney stone. Given the many advantages of PolyScope such as extensive application, minimal invasion, no blood preparation or transfusion, short hospital stay and reduced maintenance costs, urologists may take into consideration the removable modular flexible ureteroscopic management with holmium laser lithotripsy as the preferred treatment for senile patients with kidney stone.
Acknowledgements
Not applicable.
Funding
This study was funded by the Shanghai Municipal Commission of Health and Family Planning Grant (grant no. 201440314) and Shanghai Shenkang Three Year Action Project (grant no. 16CR2030B) and the Shanghai Sailing Program (grant no. 18YF1415200).
Availability of data and materials
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Authors' contributions
YH was involved in project supervision. BS, KX, JD and YW collected and analyzed the data. YH performed surgical procedures. KX, BS and YW wrote the manuscript. YW and JD corrected the language of the paper.
Ethics approval and consent to participate
The Ethics Committee of Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine has approved the study and permitted the waiver of written informed consent from patients. The study protocol is also in accordance with the Declaration of Helsinki.
Consent for publication
Publication of the data in our study does not compromise anonymity or confidentiality or breach local data protection laws.
Competing interests
The authors declare no potential conflicts of interest.
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