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Introduction

Measles, tuberculosis, influenza, meningococcal disease, whooping cough and tetanus are all infectious diseases for which there is a vaccine. And yet these are diseases that result in a large number of deaths in the third millennium (1).

Measles is an extremely contagious viral disease. It is one of the leading causes of mortality and morbidity in infants and young children despite of the availability and safety of existing vaccines (2).

Measles continues to circulate across Europe as a result of suboptimal vaccination coverage and population immunity gaps (3); Eastern Europe being one of the most affected regions for the incidence of measles (2).

A vaccine is a biological product that contains attenuated pathogens capable of inducing a protective immune response to a particular microbial aggression. The action of the vaccine can be quantified by specific antibodies that appear in the blood of the vaccinated patient (4). Over time, the administration of vaccines has reduced the incidence of a large number of diseases that pose a major threat to health in the European region and thus, vaccines have saved millions of lives.

In Central and Eastern Europe, in the totalitarian context imposed by the communist regimes, the vaccination schemes were rigorously structured and administered to the pediatric population for the entire time of the communist regime (5). As a result, there appears to be a low incidence of vaccine-controlled infectious diseases at that time.

Materials and methods

We aim to create a retrospective descriptive study in which to analyze the evolution of the measles epidemic at the European level. The documentation was carried out using European Centre for Disease Prevention and Control (ECDC) and World Health Organization (WHO) statistics from 2005 to 2020. At the same time, we present the epidemic's evolution in Romania, using data provided by the Romanian National Institute of Public Health and Ministry of Health.

The schemes of the national vaccination program at the level of European countries were analyzed retrospectively. An attempt was made to establish correlations between vaccine coverage at the state level and the number of measles-mumps-rubella (MMR) vaccine doses in the National Vaccination Programme, respectively the number of new cases of measles per 1,000 inhabitants.

In Romania, we analyzed the evolution of the measles cases during the communist regime compared with the number of cases after 1990, in the context of the decrease in vaccine coverage. We aimed to identify the cause of the increase in the percentage of cases in relation to the decrease in the percentage of vaccination in the pediatric population.

The article goes into detail with regard to the statistical differences between the number of cases of measles in children and adults before 2016, when the measles epidemic was declared, and the number of cases subsequent to the decline generated by the changes brought to the national programme in terms of measles vaccination. The new vaccination schedule is presented. This one involves the administration of 2 doses of MMR trivaccine in the first year of life and one dose of booster vaccine at the age of 5 years. The decrease in the disease incidence during 2016-2020 is statistically demonstrated.

Results and Discussion

Measles epidemic in Europe

The measles epidemic between 2010-2020 in Europe is reflected in the large number of measles cases that spread across the continent (6) (Fig. 1).

Figure 1 Measles cases (possible, probable, confirmed) between January 2010 and May 2020, reported by month and year in EU/EEA and the UK (source TESSy)-adapted from European Centre for Disease Prevention and Control (5). EU/EEA, European Union/European Economic Area.

The national vaccination schedule differs from country to country both in the epidemic time and the current period. It should be noted that, for most countries, according to ECDC, the national vaccination schedule includes two doses of measles vaccine from the MMR trivaccine (2).

A coverage of vaccination over 95% with two doses of measles vaccine is crucial to achieve, in order to eliminate the disease throughout Europe (2). The vaccine coverage rate in Europe with two doses of measles vaccine is estimated at only 90% by 2018. As a result, in 2018 in Europe, 83,540 cases of measles were reported; almost four times more than in 2017 (25,870 cases) (7).

Measles-related mortality is most often due to complications of the disease such as pneumonia or encephalitis and less to the disease itself (8). In 2019, the death rate per 1,000 cases was 0.89. The numbers may be higher if we take into account the deaths related to the complications of the disease (7). In addition, subacute sclerosing panencephalitis is a rare and invariably fatal complication of the disease. This complication develops years after the occurrence of the acute measles episode and it increases the measles mortality rate (9).

The data provided by ECDC concerning Central and Eastern Europe show significant variations from one country to another. Between March 2019 and February 2020, the number of measles cases in the analyzed countries had an overall downward evolution. Exceptions to this situation include Romania and Bulgaria which continued to present an increased number of cases in the first two months of 2020(10) (Table I).

Table I Number of cases of measles in Central and Eastern Europe between March 1, 2019 and February 29, 2020 reported monthly and per million population by country (adapted from ECDC).

Table I

Number of cases of measles in Central and Eastern Europe between March 1, 2019 and February 29, 2020 reported monthly and per million population by country (adapted from ECDC).

	Year
	Month
Country	2019 Mar	2019 Apr	2019 May	2019 Jun	2019 July	2019 Aug	2019 Sept	2019 Oct	2019 Nov	2019 Dec	2020 Jan	2020 Feb	Total cases	Cases per million
Romania	188	110	148	123	110	80	112	100	79	90	257	145	1,542	79.4
Bulgaria	185	279	281	236	84	42	17	5	21	34	81	82	1,347	192.4
Croatia	0	0	6	4	10	4	14	12	1	0	0	0	51	12.5
Cyprus	0	1	3	1	0	0	0	0	0	0	0	0	5	5.7
Czechia	198	90	49	20	14	4	2	1	4	0	0	3	385	36.1
Estonia	2	0	6	7	1	1	0	0	0	1	0	0	18	13.6
Greece	7	12	6	0	0	0	12	3	1	1	1	0	43	4
Hungary	4	2	9	0	1	0	0	0	0	0	0	0	16	1.6
Latvia	0	1	0	0	0	2	0	0	0	0	0	0	3	1.6
Lithuania	249	231	125	62	33	39	6	2	2	0	1	0	750	268.4
Poland	287	289	249	124	41	9	5	6	2	8	5	7	1,032	27.2
Slovakia	70	105	43	9	3	6	3	0	0	0	0	0	239	43.9
Slovenia	0	6	8	3	1	1	0	0	7	22	5	1	54	25.9

[i] ECDC, European Centre for Disease Prevention and Control.

The monthly measles and rubella monitoring report April 2020 of ECDC presented data concerning the incidence of measles in the 29 EU/EEA member states, including the UK. It reported 11,576 cases of measles for the interval March 1, 2019 to February 29, 2020(2). No country had zero cases during that period. France ranked first (2,466 cases) followed by Romania (1,542 cases), Italy (1,353 cases) and Bulgaria (1,347 cases). During the mentioned period, 8 deaths were reported (25% of deaths being registered in Romania) (2).

Particularities of the measles epidemic in Romania

Over time, after the introduction of the measles vaccination in 1979, measles still produced several epidemics in Romania (in 1982, 1986, 1993, 1997, 2003, 2010 and 2016) but with new cases and the number of deaths lower than were registered in the prevaccination period (11). According to the data provided by the National Institute of Public Health, the D4 genotype of measles virus is endemic in Romania (11). In the context of the democratic approach of the last decade of the 20th century which associated a free movement of the population on the background of open border circulation, two other genotypes of measles virus, B3 and D8, considered imported genotypes were identified in Romania (11,12).

Information provided by ECDC between February 1, 2016 and January 31, 2017, shows that eight European countries (Austria, Czech Republic, France, Germany, Ireland, Italy, Spain, UK) reported 34 confirmed cases of measles (12). Based on the circulated genotypes, ECDC supports the possibility that their origin was from Romania (13).

Statistical data from Romania indicate that during the 1960-1980 period, the measles incidence remained high at about 120 new cases per 100,000 population. After the introduction of the measles vaccination in 1979, there was a dramatic decrease in these numbers, below 40 new measles cases per 100,000 population (11) (Fig. 2).

Figure 2 Multiannual incidence of measles in Romania between January 1960 and July 2020. Adapted from Romanian National Institute of Public Health (9).

In Romania, the vaccination schedule was modified since 2005 by introducing in the National Vaccination Program the measles-rubella-mumps (MRM) trivaccine which is administered at the age of 12 months with a booster at the age of 6-7 years. Vaccine coverage was maintained at over 95%, the WHO target (14). As a result, the incidence of the disease continued to remain low from 2005 to 2015.

After 2015, the incidence of measles in pediatric patients increased alarmingly (11). Researchers correlate this with a significant reduction in the percentage of infants and young children vaccinated against measles secondary to a misunderstood democracy consisting in vaccine delays and refusals of vaccination (15). In addition, media coverage of Dr Andrew Wakefield's publications, established a false correlation between MMR vaccination and autism, an idea which is widely reported among parents (16). Consecutively, this resulted in a decreased trend of vaccine coverage. In 2018, only 90% of the pediatric population from Romania was covered by MMR vaccination at the age of 12 months (17).

The distribution of measles cases among the pediatric population of Romania between 2005-2019 is shown in Tables II and III based on data collected from ECDC and INSP.

Table II Distribution of measles cases among the pediatric population of Romania between 2005-2019 (adapted from ECDC).

Table II

Distribution of measles cases among the pediatric population of Romania between 2005-2019 (adapted from ECDC).

Year	2005	2006	2007	2008	2009	2010	2011	2012	2013	2014	2015	2016	2017	2018	2019
Cases	5,647	3,196	352	14	8	188	4,165	6,166	1159	59	7	1,780	7,326	4,477	2,718

[i] ECDC, European Centre for Disease Prevention and Control.

Table III Distribution of the cases of measles according to age group in the pediatric population of Romania between 2015 and 2019 (according to INSP).

Table III

Distribution of the cases of measles according to age group in the pediatric population of Romania between 2015 and 2019 (according to INSP).

	Age groups (0-19 years of age)
Cases of measles	<1 year	1-4 years	5-9 years	10-14 years	15-19 years	Total cases
2015	3	4	0	0	0	7
2016	336	842	364	152	86	1,780
2017	1,628	3,121	1,471	664	442	7,326
2018	1,292	1,482	868	515	320	4,477
2019	704	860	540	359	255	2,718
Total cases	3,963	6,309	3,243	1,690	1,103	16,308

[i] INSP, Romanian National Institute of Public Health.

Furthermore, Romania registered in 2016 a worrying number of measles cases in both children and young adults. The Romanian National Institute of Public Health stated that the most affected were children under 1 year, with 723 new cases/100,000 population, followed by the age group 1-4 years, 3 times lower, and then the incidence declined for the age group 5-9 years to 108/100,000 population and was 35.3/1,000,000 for the age group 15-19 years (11). Thus, in September 2016, a measles epidemic was declared in Romania. Afterwards, for the next two years, the trend continued to be high for the 0-4 age group as is shown in Fig. 3.

Figure 3 Evolution of cases of measles in Romania by age group between January 2015 and December 2019. Adapted from ECDC and INSP (9). ECDC, European Centre for Disease Prevention and Control; INSP, Romanian National Institute of Public Health.

Data from the ECDC showed that in the period of January-December 2020 in Romania there were 1,004 new cases of measles among the population (17). According to INSP 85.74% of cases were in the age group 0-19 years. No deaths were reported (18).

The current measles epidemic in Romania has particularly affected children under 1 year old who were not eligible for MMR vaccination according to the Romanian National Program of Vaccination from that time. Starting with December 2016, the Ministry of Health and National Institute of Public Health established the obligation to administer two doses of MMR trivaccine in the first year of life, at the ages of 9 and 12 months. The booster dose is maintained at the age of five. Romania is the only country in Central and Eastern Europe that administers 3 doses of MMR in children, 2 of which are during infancy.

During the years preceding the onset of the measles outbreak in Romania, the number of deaths caused by infections with the measles virus was incomparably lower: 2004-2007, 23 deaths; 2010-2013, 4 deaths. The number of deaths increased considerably between 2016 and 2019 reaching 64 deaths out of 18,908 diagnosed cases (11) as is shown in Table IV.

Table IV Distribution of the confirmed cases of measles and deaths in Romania between 2016 and 2020 (according to INSP).

Table IV

Distribution of the confirmed cases of measles and deaths in Romania between 2016 and 2020 (according to INSP).

	Year
Measles	2016	2017	2018	2019	Total
Cases	1,969	8,299	5,319	3,321	18,908
Deaths	9	27	23	5	64

[i] INSP, Romanian National Institute of Public Health.

The study of Lazar et al, INSP (unpublished data), showed that between January 2016 and July 2018, 14,825 patients infected with the measles virus were diagnosed in Romania. Most of them were unvaccinated patients, 14,113 (95.2%). Pediatric patients, infants and children under 5 years of age, accounted for 56% of the group (8,259).

In 2018, 23 deaths were registered in Romania out of the 74 measles-related deaths in 10 European countries. The mortality rate per 1,000 cases of measles remains at 0.89. Most of the deaths, 60% of them, occurred in children under the age of 10 and 2/3 of them have been registered at less than 1 year old (7).

As a result of the changes brought by the Romanian National Vaccination Programme in December 2016 and the concerted efforts of the Romanian medical staff, the number of measles cases in pediatric patients was reduced. The number of measles deaths has also been reduced. The dynamics of the data collected by INSP from May 2019 to May 2020 about the evolution of the measles epidemic shows a downward trend.

The data provided by the study of Pistol et al, INSP (data not published), concerning the National Electronic Vaccination Registry are summarized in Table V and indicate the vaccination rates with 3 doses of MMR during January-July 2020 in Romania. The data show a vaccination rate between 40-50% among infants except for April 2020 when the recent pandemic with the Sars-CoV-2 virus was declared on the Romanian territory, and possibly the measures taken during that month decreased the level of vaccinations for a short period.

Table V MMR vaccination rate among the pediatric population between January and July 2020 (according to INSP).

Table V

MMR vaccination rate among the pediatric population between January and July 2020 (according to INSP).

	MMR
Month for year 2020	9-11 months	12 months	5 years
January	44.1	49.4	24.7
February	42	47.1	22
March	38.8	47.6	20.8
April	28.1	31.8	12.1
May	47	51.4	27.2
June	46.1	52.5	24.8
July	41.1	51.1	25.2

[i] MMR, measles-mumps-rubella; INSP, Romanian National Institute of Public Health.

Thus according to INSP, the incidence of measles at the national level in 2020 was only 5.1/100.000 inhabitants, approximately 4 times lower than in 2019. In the last 6 months, 17 districts out of the 41 districts of Romania have not reported confirmed measles cases. In addition, no measles deaths were reported between December 2019 and November 2020(18).

In this context, the authorities have decided to discontinue the dose of MMR vaccine administered to infants at 9 months of life returning to the vaccination schedule with two doses of MMR (at the age of 1 year and booster at 5 years). This decision was applied starting from August 1, 2020.

We argue the importance of rigorous surveillance in the next period for new measles cases in both children and adults. The new incidence of the disease will decide if these recommendations were correct. If a large number of newly confirmed cases of measles disease appear, the authorities will consider resuming the vaccination schedule with the administration of two doses of MMR at 9 and 12 months and a booster at the age of 5 years.

We take into consideration the possibility of an apparent decline of the disease in the last 4 months in the context of the Sars-CoV-2 virus epidemic in Romania (19). In the context of the pandemic, Romania was in the period of March-May 2020 under the incidence of the emergency state and later, from May to August 2020, under the incidence of the alert state (20). The recommendations for social distancing from this period led to the limitation of the infectious contact between people (21). We consider that indirectly this may have led to a decrease in the measles incidence in Romania.

In conclusion, vaccination is the most effective protection against measles disease and immunization in childhood is the safest start to our road in life.

The measles epidemic appeared in Romania secondary to a decline in vaccine coverage, a phenomenon that was mitigated by adaptive measures that included the development of a vaccination schedule with 3 doses of MMR vaccines which means the introduction of an additional dose at the age of 9 months, with the administration of the following doses at the age of 12 months and 5 years.

The national campaign to limit the measles epidemic had the desired effect. The decrease in the incidence of measles cases among the pediatric population of Romania allowed the authorities to discontinue the MMR vaccine dose administered during the infant period at 9 months starting with August 2020.

We sought to evaluate the decision of the Ministry of Health to discontinue the administration of an additional dose of MMR vaccine during infancy. Early detection of epidemiological signals is important in order to prevent a new measles epidemic. Thus, it is necessary to dynamically monitor new disease cases that will appear on the Romanian territory. Interdisciplinary monitoring of the pediatric patient will detect an increase in the incidence of measles. Consecutively, the second dose of vaccination during infancy may have to be reintroduced.

We point out the possibility of an artificial decrease in the number of measles diseases from January to July 2020 in the context of the social distancing imposed by the Sars-CoV-2 pandemic.

Acknowledgements

Not applicable.

Funding

Funding: No funding was received.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Authors' contributions

AMD conceived of the presented idea. SC developed the theory and performed the computations. LS verified the analytical methods. DAP supervised the literature review and data used. MD was involved in drafting the manuscript and revising it critically for important intellectual content in light of the literature data. CGC also analyzed the data provided and gave final approval of the version to be published, investigate the aspects of the data and supervised the findings of this work. All authors discussed the results and contributed to the final version of the manuscript. All authors read and approved the manuscript and agree to be accountable for all aspects of the research.

Ethics approval and consent to participate

Not applicable.

Patient consent for publication

Not applicable.

Competing interests

No competing interests exist with regard to the publication of the descriptive study.

References