Open Access

Almonertinib as a neoadjuvant therapy for patients with a superior pulmonary sulcus tumor with activated EGFR mutation: A case report

  • Authors:
    • Kai Kang
    • Zhixiao Jiang
    • Jindan Kai
    • Si Chen
    • Fei Xiong
  • View Affiliations

  • Published online on: October 20, 2023     https://doi.org/10.3892/etm.2023.12263
  • Article Number: 564
  • Copyright: © Kang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A superior pulmonary sulcus tumor, also known as a Pancoast tumor, invades tissues or organs at the entrance of the thorax, such as the brachial plexus, upper ribs, vertebrae, subclavian vessels and stellate ganglia. Induction concurrent chemoradiotherapy followed by radical surgical resection is the preferred treatment. The present study reported the case of a 52‑year‑old male who presented at Hubei Cancer Hospital, Tongji Medical College (Wuhan, Hubei) with left chest pain and an abnormal chest computed tomography scan showing a mass of 81x43 mm in the left upper chest wall that invaded the first, second and third anterior ribs. Biopsy of the mass showed stage cT4N0M0, IIIA, poorly differentiated adenocarcinoma and epidermal growth factor receptor+. The patient was treated by induction chemotherapy and targeted therapy, which was followed by surgical resection of the left upper lobe and the affected chest wall via the transmanubrial approach. The targeted therapy with almonertinib was continued postoperatively. To date, no disease recurrence has been detected during the 4 months follow‑up.
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December-2023
Volume 26 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Kang K, Jiang Z, Kai J, Chen S and Xiong F: Almonertinib as a neoadjuvant therapy for patients with a superior pulmonary sulcus tumor with activated EGFR mutation: A case report. Exp Ther Med 26: 564, 2023
APA
Kang, K., Jiang, Z., Kai, J., Chen, S., & Xiong, F. (2023). Almonertinib as a neoadjuvant therapy for patients with a superior pulmonary sulcus tumor with activated EGFR mutation: A case report. Experimental and Therapeutic Medicine, 26, 564. https://doi.org/10.3892/etm.2023.12263
MLA
Kang, K., Jiang, Z., Kai, J., Chen, S., Xiong, F."Almonertinib as a neoadjuvant therapy for patients with a superior pulmonary sulcus tumor with activated EGFR mutation: A case report". Experimental and Therapeutic Medicine 26.6 (2023): 564.
Chicago
Kang, K., Jiang, Z., Kai, J., Chen, S., Xiong, F."Almonertinib as a neoadjuvant therapy for patients with a superior pulmonary sulcus tumor with activated EGFR mutation: A case report". Experimental and Therapeutic Medicine 26, no. 6 (2023): 564. https://doi.org/10.3892/etm.2023.12263