Open Access

Impact of premorbid use of beta‑blockers on survival outcomes of patients with sepsis: A systematic review and meta‑analysis

  • Authors:
    • Huan Chu
    • Fengmin Fei
    • Yao Su
    • Huifei Zhou
  • View Affiliations

  • Published online on: May 24, 2024     https://doi.org/10.3892/etm.2024.12589
  • Article Number: 300
  • Copyright: © Chu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It is unclear if premorbid use of beta‑blockers affects sepsis outcomes. The present systematic review aimed to assess the impact of premorbid beta‑blocker use on mortality and the need for mechanical ventilation in patients with sepsis. Embase, Scopus, PubMed and Web of Science were searched for studies comparing outcomes of patients with sepsis based on the premorbid use of beta‑blockers. The primary outcome was mortality, and the secondary outcome was the need for mechanical ventilation. The results were reported as odds ratios (ORs) with 95% confidence intervals (CIs). A total of 17 studies including 64,586 patients with sepsis were included. Of them, 8,665 patients received premorbid beta‑blockers and 55,921 patients were not treated with premorbid beta‑blockers and served as a control group. Pooled analysis of mortality rates revealed that premorbid use of beta‑blockers did not affect in‑hospital mortality (OR: 0.96; 95% CI: 0.78, 1.18; and I2=63%) but significantly reduced one‑month mortality rates (OR: 0.83; 95% CI: 0.72, 0.96; and I2=63%). Combined analysis of adjusted data showed that premorbid beta‑blockers were associated with a significant survival advantage in patients with sepsis (OR: 0.81; 95% CI: 0.72, 0.92; and I2=70%). However, there was no effect of premorbid use of beta‑blockers on the need for mechanical ventilation (OR: 0.93; 95% CI: 0.66, 1.30); and I2=72%). The results of the present study indicated that premorbid use of beta‑blockers is associated with improved survival in patients with sepsis. However, it does not impact the need for mechanical ventilation. The results should be interpreted with caution as the data is observational and unadjusted.
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July-2024
Volume 28 Issue 1

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Spandidos Publications style
Chu H, Fei F, Su Y and Zhou H: Impact of premorbid use of beta‑blockers on survival outcomes of patients with sepsis: A systematic review and meta‑analysis. Exp Ther Med 28: 300, 2024.
APA
Chu, H., Fei, F., Su, Y., & Zhou, H. (2024). Impact of premorbid use of beta‑blockers on survival outcomes of patients with sepsis: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 28, 300. https://doi.org/10.3892/etm.2024.12589
MLA
Chu, H., Fei, F., Su, Y., Zhou, H."Impact of premorbid use of beta‑blockers on survival outcomes of patients with sepsis: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 28.1 (2024): 300.
Chicago
Chu, H., Fei, F., Su, Y., Zhou, H."Impact of premorbid use of beta‑blockers on survival outcomes of patients with sepsis: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 28, no. 1 (2024): 300. https://doi.org/10.3892/etm.2024.12589