Psychological aspect of cancer: From stressor to cancer progression (Review)

Yuan,Aihua; Wang,Shukui; Li,Zongfang; Huang,Chen

doi:10.3892/etm_00000003

Psychological aspect of cancer: From stressor to cancer progression (Review)

Authors:
- Aihua Yuan
- Shukui Wang
- Zongfang Li
- Chen Huang
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Affiliations: Department of General Surgery, Nanjing First Hospital Affiliated to Nanjing Medical University, Jiangsu 210006, P.R. China
Published online on: January 1, 2010 https://doi.org/10.3892/etm_00000003
Pages: 13-18

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Abstract

Substantial evidence indicates that psychological stress can influence the incidence and progression of cancers, and adequate psychotherapies are beneficial to cancer patients. Recently, the mechanisms responsible for the effects of psychological stress on cancer cells have been extensively investigated at the systemic, biochemical and molecular levels. Accumulating data indicate that the effects of psychological stress on cancer cells are mainly mediated by key stress-related mediators and their corresponding receptors in multi-fold pathways: chronic stressors act on the paraventricular nucleus and the suprachiasmatic nuclei. The effects are then transmitted through the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis, amplified by the unchecked release of stress-related mediators and altered behaviors. These mediators act as immunosuppressors or mitogens in the tumor micro-environment. The converging effects of psychological stress on cancer cells finally signal through receptors of the stress mediators and cytokines to activate the intracellular pro-proliferative and pro-migratory signaling pathways, and reset the molecular clock in tumor cells. Understanding these action mechanisms of psychological stress in promoting the growth and invasion of cancer cells is crucial for devising effective interventions.

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1.	Riley V: Mouse mammary tumors: alteration of incidence as apparent function of stress. Science. 189:465–467. 1975. View Article : Google Scholar : PubMed/NCBI
2.	Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, McDonald PG, Stefanek M and Sood AK: The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer. 6:240–248. 2006. View Article : Google Scholar : PubMed/NCBI
3.	Massie MJ: Prevalence of depression in patients with Cancer. J Natl Cancer Inst Monogr. 32:57–71. 2004. View Article : Google Scholar : PubMed/NCBI
4.	Carlson LE, Angen M, Cullum J, Goodey E, Koopmans J, Lamont L, MacRae JH, Martin M, Pelletier G, Robinson J, Simpson JS, Speca M, Tillotson L and Bultz BD: High levels of untreated distress and fatigue in cancer patients. Br J Cancer. 90:2297–2304. 2004.PubMed/NCBI
5.	Garssen B: Psychological factors and cancer development: evidence after 30 years of research. Clin Psychol Rev. 24:315–338. 2004.PubMed/NCBI
6.	Chida Y, Hamer M, Wardle J and Steptoe A: Do stress-related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol. 5:466–475. 2008. View Article : Google Scholar : PubMed/NCBI
7.	Thaker PH, Han LY, Kamat AA, Arevalo JM, Takahashi R, Lu C, Jennings NB, Armaiz-Pena G, Bankson JA, Ravoori M, Merritt WM, Lin YG, Mangala LS, Kim TJ, Coleman RL, Landen CN, Li Y, Felix E, Sanguino AM, Newman RA, Lloyd M, Gershenson DM, Kundra V, Lopez-Berestein G, Lutgendorf SK, Cole SW and Sood AK: Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med. 12:939–944. 2006. View Article : Google Scholar : PubMed/NCBI
8.	Sood AK, Bhatty R, Kamat AA, Landen CN, Han L, Thaker PH, Li Y, Gershenson DM, Lutgendorf S and Cole SW: Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res. 12:369–375. 2006. View Article : Google Scholar : PubMed/NCBI
9.	McEwen BS: Mood disorders and allostatic load. Biol Psychiatry. 54:200–207. 2003. View Article : Google Scholar : PubMed/NCBI
10.	Vanitallie TB: Stress: a risk factor for serious illness. Metabolism. 51:40–45. 2002. View Article : Google Scholar : PubMed/NCBI
11.	Fu L and Lee CC: The circadian clock: pacemaker and tumour suppressor. Nat Rev Cancer. 3:350–361. 2003. View Article : Google Scholar : PubMed/NCBI
12.	Sephton S and Spiegel D: Circadian disruption in cancer: a neuroendocrine-immune pathway from stress to disease? Brain Behav Immun. 17:321–328. 2003. View Article : Google Scholar : PubMed/NCBI
13.	Glaser R and Glaser JK: Stress-induced immune dysfunction: implications for health. Nat Rev Immunol. 5:243–251. 2005. View Article : Google Scholar : PubMed/NCBI
14.	Reiche EM, Nunes SO and Morimoto HK: Stress, depression, the immune system and cancer. Lancet Oncol. 5:617–625. 2004. View Article : Google Scholar : PubMed/NCBI
15.	Padgett DA and Glaser R: How stress influences the immune response. Trends Immunol. 24:444–448. 2003. View Article : Google Scholar : PubMed/NCBI
16.	Segerstrom SC and Miller GE: Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychol Bull. 130:601–630. 2004.PubMed/NCBI
17.	Lutgendorf SK, Cole S, Costanzo E, Bradley S, Coffin J, Jabbari S, Rainwater K, Ritchie JM, Yang M and Sood AK: Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res. 9:4514–4521. 2003.PubMed/NCBI
18.	Hall RA: Beta-adrenergic receptors and their interacting proteins. Semin Cell Dev Biol. 15:281–288. 2004. View Article : Google Scholar : PubMed/NCBI
19.	Dorsam RT and Gutkind JS: G-protein-coupled receptors and cancer. Nat Rev Cancer. 7:79–94. 2007. View Article : Google Scholar : PubMed/NCBI
20.	O’Connor KL and Mercurio AM: Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells. J Biol Chem. 276:47895–47900. 2001.PubMed/NCBI
21.	Rangarajan S, Enserink JM, Kuiperij HB, Rooij J, Price LS, Schwede F and Bos JL: Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the β2-adrenergic receptor. J Cell Biol. 160:487–493. 2003.PubMed/NCBI
22.	Schmitt JM and Stork JS: β2-Adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf. J Biol Chem. 275:25342–25350. 2000.
23.	Shenoy SK, Drake MT, Nelson CD, Houtz DA, Kunhong X, Madabushi S, Reiter E, Premont RT, Lichtarge O and Lefkowitz RJ: β-arrestin-dependent, G protein-independent ERK1/2 activation by the β2-adrenergic receptor. J Biol Chem. 281:1261–1273. 2006.
24.	Tsurutani J, Castillo SS, Brognard J, Granville CA, Chunyu Z, Gills JJ, Sayyah J and Dennis PA: Tobacco components stimulate Akt-dependent proliferation and NF-κB-dependent survival in lung cancer cells. Carcinogenesis. 26:1182–1195. 2005.PubMed/NCBI
25.	Maudsley S, Pierce KL, Zamah AM, Miller WE, Ahn S, Daaka Y, Lefkowitz RJ and Luttrell LM: The β2-Adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J Biol Chem. 275:9560–9572. 2000.
26.	Drube S, Stirnweiss J, Valkova C and Liebmann C: Ligand-independent and EGF receptor-supported transactivation: lessons from beta2-adrenergic receptor signalling. Cell Signal. 18:1633–1646. 2006. View Article : Google Scholar : PubMed/NCBI
27.	Herr I, Ucur E, Herzer K, Okouoyo S, Ridder R, Krammer PH, Doeberitz MK and Debatin KM: Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas. Cancer Res. 63:3112–3120. 2003.PubMed/NCBI
28.	Herr I and Pfitzenmaier J: Glucocorticoid use in prostate cancer and other solid tumours: implications for effectiveness of cytotoxic treatment and metastases. Lancet Oncol. 7:425–430. 2006. View Article : Google Scholar : PubMed/NCBI
29.	NØrgaard P and Poulsen HS: Glucocorticoid receptors in human malignancies: a review. Ann Oncol. 2:541–557. 1991.PubMed/NCBI
30.	Petrella A, Ercolino SF, Festa M, Gentilella A, Tosco A, Conzen SD and Parente L: Dexamethasone inhibits TRAIL-induced apoptosis of thyroid cancer cells via Bcl-xL induction. Eur J Cancer. 42:3287–3293. 2006. View Article : Google Scholar : PubMed/NCBI
31.	Runnebaum IB and Brüning A: Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 11:6325–6332. 2005. View Article : Google Scholar : PubMed/NCBI
32.	Hadcock JR, Wang HY and Malbon CC: Agonist-induced destabilization of beta-adrenergic receptor mRNA. Attenuation of glucocorticoid-induced up-regulation of beta-adrenergic receptors. J Biol Chem. 264:19928–19933. 1989.PubMed/NCBI
33.	Landen CN Jr, Lin YG, Armaiz Pena GN, Das PD, Arevalo JM, Kamat AA, Han LY, Jennings NB, Spannuth WA, Thaker PH, Lutgendorf SK, Savary CA, Sanguino AM, Lopez-Berestein G, Cole SW and Sood AK: Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer. Cancer Res. 67:10389–10396. 2007. View Article : Google Scholar : PubMed/NCBI
34.	Liping Z, Cui R, Xiaodong CH and Jie D: Antiapoptotic effect of serum and glucocorticoid-inducible protein kinase is mediated by novel mechanism activating IκB kinase. Cancer Res. 65:457–464. 2005.PubMed/NCBI
35.	Wei W, Min Z, Brickley DR, Pew T and Conzen SD: Glucocorticoid receptor activation signals through forkhead transcription factor 3a in breast cancer cells. Mol Endocrinol. 20:2304–2314. 2006. View Article : Google Scholar : PubMed/NCBI
36.	Goodspeed MC and Lee CC: Tumor suppression and circadian function. J Biol Rhythms. 22:291–298. 2007. View Article : Google Scholar
37.	Hastings M, O’Neill JS and Maywood ES: Circadian clocks: regulators of endocrine and metabolic rhythms. J Endocrinol. 195:187–198. 2007. View Article : Google Scholar : PubMed/NCBI
38.	Chen ST, Choo KB, Hou MF, Yeh KT, Kuo SJ and Chang JG: Deregulated expression of the PER1, -PER2 and PER3 genes in breast cancers. Carcinogenesis. 26:1241–1246. 2005. View Article : Google Scholar : PubMed/NCBI
39.	Rasmuson T, Ljungberg B, Grankvist K, Jacobsen J and Olsson T: Increased serum cortisol levels are associated with high tumour grade in patients with renal cell carcinoma. Acta Oncol. 40:83–87. 2001. View Article : Google Scholar : PubMed/NCBI
40.	Dickmeis T: Glucocorticoids and the circadian clock. J Endocrinol. 200:3–22. 2009. View Article : Google Scholar
41.	Andersen BL, Farrar WB, Golden-Kreutz DM, Glaser R, Emery CF, Crespin TR, Shapiro CL and Carson WE: Psychological, behavioral and immune changes after a psychological intervention: a clinical trial. J Clin Oncol. 22:3570–3580. 2004. View Article : Google Scholar : PubMed/NCBI
42.	Jacobsen PB and Jim HS: Psychosocial interventions for anxiety and depression in adult cancer patients: achievements and challenges. CA Cancer J Clin. 58:214–230. 2008. View Article : Google Scholar : PubMed/NCBI
43.	Küchler T, Bestmann B, Rappat S, Henne-Bruns D and Wood-Dauphinee S: Impact of psychotherapeutic support for patients with gastrointestinal cancer undergoing surgery: 10-year survival results of a randomized trial. J Clin Oncol. 25:2702–2708. 2007.PubMed/NCBI
44.	Steingart AB and Cotterchio M: Do antidepressants cause, promote, or inhibit cancers? J Clin Epidemiol. 48:1407–1412. 1995. View Article : Google Scholar : PubMed/NCBI
45.	Brandes LJ: Hormetic effects of hormones, antihormones and antidepressants on cancer cell growth in culture: in vivo correlates. Crit Rev Toxicol. 35:587–592. 2005. View Article : Google Scholar : PubMed/NCBI
46.	Algazi M, Plu-Bureau G, Flahault A, Dondon MG and Le MG: Is beta-blocker treatment associated with a decrease in the risk of cancer? Drug Des Discov. 3:653–661. 2006. View Article : Google Scholar
47.	Benish M, Bartal I, Goldfarb Y, Levi1 B, Avraham1 R, Raz A and Ben-Eliyahu S: Perioperative use of β-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. Ann Surg Oncol. 15:2042–2052. 2008.
48.	Boesen EH and Johansen C: Impact of psychotherapy on cancer survival: time to move on? Curr Opin Oncol. 20:372–377. 2008. View Article : Google Scholar : PubMed/NCBI