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Black tea theaflavins induce programmed cell death in cultured human stomach cancer cells.

  • Authors:
    • H Hibasami
    • T Komiya
    • Y Achiwa
    • K Ohnishi
    • T Kojima
    • K Nakanishi
    • Y Sugimoto
    • M Hasegawa
    • R Akatsuka
    • Y Hara

  • View Affiliations

  • Published online on: April 1, 1998     https://doi.org/10.3892/ijmm.1.4.725
  • Pages: 725-732
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The exposure of human stomach cancer KATO III cells to black tea theaflavin extract, free theaflavin, and theaflavin digallate that are main components of the extract, led to both growth inhibition and the induction of programmed cell death (apoptosis). Morphological changes showing apoptotic bodies were observed in the cells treated with black tea theaflavin extract, theaflavin and theaflavin digallate. The fragmentations by these theaflavin compounds of DNA to oligonucleosomal-sized fragments that are characteristics of apoptosis were observed to be concentration- and time-dependent. These data suggest that drinking of black tea in large amounts is recommended to protect humans from stomach cancer.

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Journal Cover

Apr 1998
Volume 1 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Hibasami H, Komiya T, Achiwa Y, Ohnishi K, Kojima T, Nakanishi K, Sugimoto Y, Hasegawa M, Akatsuka R, Hara Y, Hara Y, et al: Black tea theaflavins induce programmed cell death in cultured human stomach cancer cells.. Int J Mol Med 1: 725-732, 1998.
APA
Hibasami, H., Komiya, T., Achiwa, Y., Ohnishi, K., Kojima, T., Nakanishi, K. ... Hara, Y. (1998). Black tea theaflavins induce programmed cell death in cultured human stomach cancer cells.. International Journal of Molecular Medicine, 1, 725-732. https://doi.org/10.3892/ijmm.1.4.725
MLA
Hibasami, H., Komiya, T., Achiwa, Y., Ohnishi, K., Kojima, T., Nakanishi, K., Sugimoto, Y., Hasegawa, M., Akatsuka, R., Hara, Y."Black tea theaflavins induce programmed cell death in cultured human stomach cancer cells.". International Journal of Molecular Medicine 1.4 (1998): 725-732.
Chicago
Hibasami, H., Komiya, T., Achiwa, Y., Ohnishi, K., Kojima, T., Nakanishi, K., Sugimoto, Y., Hasegawa, M., Akatsuka, R., Hara, Y."Black tea theaflavins induce programmed cell death in cultured human stomach cancer cells.". International Journal of Molecular Medicine 1, no. 4 (1998): 725-732. https://doi.org/10.3892/ijmm.1.4.725