search button

Response of HT29 cells to butyrate depends on time of exposure and glucose deprivation

  • Authors:
    • Dana Kucerová
    • Jitka Stokrová
    • Jan Korb
    • Eva Sloncová
    • Zdena Tuhácková
    • Vlasta Sovová

  • View Affiliations

  • Published online on: December 1, 2002     https://doi.org/10.3892/ijmm.10.6.779
  • Pages: 779-784
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The high level of alkaline phosphatase activity in HT29 cells induced after 2 or 5 days of butyrate treatment was decreased during their prolonged exposure (about 30 days) to this agent together with a decrease of sensitivity to apoptosis. However, an enormous additive effect on alkaline phosphatase activity was found after butyrate treatment of glucose-starved cells. In concert with this finding, the substructural analysis revealed a dense brush border, tendency to polarization and morphologically normal mitochondria. It can be concluded that prolonged butyrate treatment of HT29 cells attenuated their response to this agent. On the other hand, glucose deprivation, as another inductor of differentiation, was found to increase the sensitivity of HT29 cells to butyrate.

Related Articles

Journal Cover

December 2002
Volume 10 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Kucerová D, Stokrová J, Korb J, Sloncová E, Tuhácková Z and Sovová V: Response of HT29 cells to butyrate depends on time of exposure and glucose deprivation. Int J Mol Med 10: 779-784, 2002.
APA
Kucerová, D., Stokrová, J., Korb, J., Sloncová, E., Tuhácková, Z., & Sovová, V. (2002). Response of HT29 cells to butyrate depends on time of exposure and glucose deprivation. International Journal of Molecular Medicine, 10, 779-784. https://doi.org/10.3892/ijmm.10.6.779
MLA
Kucerová, D., Stokrová, J., Korb, J., Sloncová, E., Tuhácková, Z., Sovová, V."Response of HT29 cells to butyrate depends on time of exposure and glucose deprivation". International Journal of Molecular Medicine 10.6 (2002): 779-784.
Chicago
Kucerová, D., Stokrová, J., Korb, J., Sloncová, E., Tuhácková, Z., Sovová, V."Response of HT29 cells to butyrate depends on time of exposure and glucose deprivation". International Journal of Molecular Medicine 10, no. 6 (2002): 779-784. https://doi.org/10.3892/ijmm.10.6.779