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Detailed Hylobates lar karyotype defined by 25-color FISH and multicolor banding

  • Authors:
    • Kristin Mrasek
    • Anita Heller
    • Nikolai Rubtsov
    • Vladimir Trifonov
    • Heike Starke
    • Uwe Claussen
    • Thomas Liehr

  • View Affiliations

  • Published online on: August 1, 2003     https://doi.org/10.3892/ijmm.12.2.139
  • Pages: 139-146
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Abstract

A comprehensive and detailed comparative chromosome map of the white-handed gibbon (Hylobates lar = HLA) has been established by hybridizing the recently developed complete human multicolor banding (MCB) probe set on metaphase chromosomes of a male HLA lymphoblastoid cell line. Thus, it was possible to precisely determine the breakpoints and distribution plus orientation of specific DNA-regions in this cytogenetically highly rearranged species compared to Homo sapiens (HSA). In general, the obtained results are in concordance with previous molecular-cytogenetic studies. In this study all 71 breakpoints present in HLA compared to HSA could be determined exactly. This study is a valuable complement to our knowledge on the phylogeny of huminoid chromosomes.

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Journal Cover

August 2003
Volume 12 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Mrasek K, Heller A, Rubtsov N, Trifonov V, Starke H, Claussen U and Liehr T: Detailed Hylobates lar karyotype defined by 25-color FISH and multicolor banding. Int J Mol Med 12: 139-146, 2003.
APA
Mrasek, K., Heller, A., Rubtsov, N., Trifonov, V., Starke, H., Claussen, U., & Liehr, T. (2003). Detailed Hylobates lar karyotype defined by 25-color FISH and multicolor banding. International Journal of Molecular Medicine, 12, 139-146. https://doi.org/10.3892/ijmm.12.2.139
MLA
Mrasek, K., Heller, A., Rubtsov, N., Trifonov, V., Starke, H., Claussen, U., Liehr, T."Detailed Hylobates lar karyotype defined by 25-color FISH and multicolor banding". International Journal of Molecular Medicine 12.2 (2003): 139-146.
Chicago
Mrasek, K., Heller, A., Rubtsov, N., Trifonov, V., Starke, H., Claussen, U., Liehr, T."Detailed Hylobates lar karyotype defined by 25-color FISH and multicolor banding". International Journal of Molecular Medicine 12, no. 2 (2003): 139-146. https://doi.org/10.3892/ijmm.12.2.139