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Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: Correlation with symptoms and aortic diameter

  • Authors:
    • Efstathios Papalambros
    • Fragiska Sigala
    • Sotiris Georgopoulos
    • Charalambos Menekakos
    • Alexandra Giatromanolaki
    • Elias Bastounis
    • Efthymios Sivridis

  • View Affiliations

  • Published online on: December 1, 2003     https://doi.org/10.3892/ijmm.12.6.965
  • Pages: 965-968
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Abstract

Our purpose was to investigate the expression of matrix metalloproteinase (MMP)-2 and -9 in all types of abdominal aortic aneurysms (AAA): symptomatic, asymptomatic, and ruptured. MMP-2 and -9 activity was investigated in surgical samples from the arterior wall of 46 AAA, using a standard immunohistochemical technique. The MMP-9 activity was significantly higher in large AAA (>6 cm), but there was no relation between AAA size and MMP-2 activity. Neither MMP-2 nor MMP-9 were related with AAA rupture, other complications or symptoms. The MMP-9 activity in AAA is a determinant of the aneurysm size, but it is not related to clinical manifestations.

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Journal Cover

December 2003
Volume 12 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Papalambros E, Sigala F, Georgopoulos S, Menekakos C, Giatromanolaki A, Bastounis E and Sivridis E: Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: Correlation with symptoms and aortic diameter. Int J Mol Med 12: 965-968, 2003.
APA
Papalambros, E., Sigala, F., Georgopoulos, S., Menekakos, C., Giatromanolaki, A., Bastounis, E., & Sivridis, E. (2003). Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: Correlation with symptoms and aortic diameter. International Journal of Molecular Medicine, 12, 965-968. https://doi.org/10.3892/ijmm.12.6.965
MLA
Papalambros, E., Sigala, F., Georgopoulos, S., Menekakos, C., Giatromanolaki, A., Bastounis, E., Sivridis, E."Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: Correlation with symptoms and aortic diameter". International Journal of Molecular Medicine 12.6 (2003): 965-968.
Chicago
Papalambros, E., Sigala, F., Georgopoulos, S., Menekakos, C., Giatromanolaki, A., Bastounis, E., Sivridis, E."Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: Correlation with symptoms and aortic diameter". International Journal of Molecular Medicine 12, no. 6 (2003): 965-968. https://doi.org/10.3892/ijmm.12.6.965