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Plasminogen activator inhibitor type-1: Its structure, biological activity and role in tumorigenesis (Review)

  • Authors:
    • Joanna Chorostowska-Wynimko
    • Ewa Skrzypczak-Jankun
    • Jerzy Jankun

  • View Affiliations

  • Published online on: June 1, 2004     https://doi.org/10.3892/ijmm.13.6.759
  • Pages: 759-766
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Plasminogen activator inhibitor type-1 (PAI-1), is a unique member of serpin superfamily, the primary regulator of plasminogen activation and therefore essential factor regulating physiological thrombotic/fibrinolytic balance in vivo. Via interactions with integrins and extracellular matrix components it orchestrates also cell adhesion and migration. Therefore, PAI-1 is considered one of the key regulators of tumor invasion and metastasis, as well as cancer-related angiogenesis. This review summarizes recent findings on the structure and functional activity of the plasminogen activator inhibitor type-1, and current opinions on its role in tumorigenesis.

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Journal Cover

June 2004
Volume 13 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Chorostowska-Wynimko J, Skrzypczak-Jankun E and Jankun J: Plasminogen activator inhibitor type-1: Its structure, biological activity and role in tumorigenesis (Review). Int J Mol Med 13: 759-766, 2004.
APA
Chorostowska-Wynimko, J., Skrzypczak-Jankun, E., & Jankun, J. (2004). Plasminogen activator inhibitor type-1: Its structure, biological activity and role in tumorigenesis (Review). International Journal of Molecular Medicine, 13, 759-766. https://doi.org/10.3892/ijmm.13.6.759
MLA
Chorostowska-Wynimko, J., Skrzypczak-Jankun, E., Jankun, J."Plasminogen activator inhibitor type-1: Its structure, biological activity and role in tumorigenesis (Review)". International Journal of Molecular Medicine 13.6 (2004): 759-766.
Chicago
Chorostowska-Wynimko, J., Skrzypczak-Jankun, E., Jankun, J."Plasminogen activator inhibitor type-1: Its structure, biological activity and role in tumorigenesis (Review)". International Journal of Molecular Medicine 13, no. 6 (2004): 759-766. https://doi.org/10.3892/ijmm.13.6.759