Induction of apoptosis by ar-turmerone on various cell lines
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- Published online on: August 1, 2004 https://doi.org/10.3892/ijmm.14.2.253
- Pages: 253-256
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Abstract
This study investigated the cytotoxic effect of ar-turmerone isolated from turmeric (Curcuma longa L) on the K562, L1210, U937 and RBL-2H3 cell lines by the MTT assay. Ar-turmerone exhibited potent cytotoxicity on these cancer cell lines. The IC50 values of ar-turmerone on these cell lines were 20-50 µg/ml. They showed an increased inhibition ratio on cell viability according to the drug concentration ≤80 µg/ml in the cell lines tested. The DNA fragmentation that is a characteristic of apoptosis due to ar-turmerone occurred in a concentration- and time-dependent manner in the K562, L1210, U937 and RBL-2H3 cancer cell lines. These results suggest that ar-turmerone can induce the apoptotic activity in the K562, L1210, U937 and RBL-2H3 cells.
