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UV radiation down-regulates Dsg-2 via Rac/NADPH oxidase-mediated generation of ROS in human lens epithelial cells

  • Authors:
    • Qin Jiang
    • Changlin Zhou
    • Sarah Healey
    • Wenming Chu
    • Nicola Kouttab
    • Zhigang Bi
    • Yinsheng Wan

  • View Affiliations

  • Published online on: August 1, 2006     https://doi.org/10.3892/ijmm.18.2.381
  • Pages: 381-387
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Abstract

Ultraviolet radiation-induced cataract has been believed to be associated with degradation of cellular components. We report that, in cultured human lens epithelial cells, UV radiation analogous to H2O2 treatment down-regulates desmosomal protein desmoglein-2. UV radiation induces generation of reactive oxygen species and transiently activates epidermal growth factor receptor, which in turn induces translocation of Rac2 and NADPH oxidase activity. Collectively, our data demonstrate that UV-induced desmoglein-2 down-regulation is mediated reactive oxygen species which are generated through EGFR activation and Rac2/NADPH oxidase activation, suggesting that antioxidants may be applied for protection against UV-induced cataract.

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Journal Cover

August 2006
Volume 18 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Jiang Q, Zhou C, Healey S, Chu W, Kouttab N, Bi Z and Wan Y: UV radiation down-regulates Dsg-2 via Rac/NADPH oxidase-mediated generation of ROS in human lens epithelial cells. Int J Mol Med 18: 381-387, 2006.
APA
Jiang, Q., Zhou, C., Healey, S., Chu, W., Kouttab, N., Bi, Z., & Wan, Y. (2006). UV radiation down-regulates Dsg-2 via Rac/NADPH oxidase-mediated generation of ROS in human lens epithelial cells. International Journal of Molecular Medicine, 18, 381-387. https://doi.org/10.3892/ijmm.18.2.381
MLA
Jiang, Q., Zhou, C., Healey, S., Chu, W., Kouttab, N., Bi, Z., Wan, Y."UV radiation down-regulates Dsg-2 via Rac/NADPH oxidase-mediated generation of ROS in human lens epithelial cells". International Journal of Molecular Medicine 18.2 (2006): 381-387.
Chicago
Jiang, Q., Zhou, C., Healey, S., Chu, W., Kouttab, N., Bi, Z., Wan, Y."UV radiation down-regulates Dsg-2 via Rac/NADPH oxidase-mediated generation of ROS in human lens epithelial cells". International Journal of Molecular Medicine 18, no. 2 (2006): 381-387. https://doi.org/10.3892/ijmm.18.2.381