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Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice

  • Authors:
    • Shengjun Wang
    • Huaxi Xu
    • Yongzhong Wang
    • Jie Ma
    • Chaoming Mao
    • Qixiang Shao
    • Bin Ma
    • Wenrong Xu
    • Shengli Yang

  • View Affiliations

  • Published online on: December 1, 2006     https://doi.org/10.3892/ijmm.18.6.1193
  • Pages: 1193-1199
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

CD4+CD25+ regulatory T (Treg) cells are immunosuppressive and help maintain peripheral immune tolerance. The forkhead/winged helix family member, Foxp3, has been shown to be a critical regulator of CD4+CD25+ Treg cells. We demonstrate by quantitative real-time PCR that CD4+CD25+ T cells express higher levels of Foxp3 mRNA than other T cell populations. Recombinant adeno-associated virus vector carrying mouse Foxp3 gene under the control of the CMV promoter was generated and used to transduce CD4+CD25− T cells. These Foxp3-transduced T cells are similar to naturally occurring CD4+CD25+ regulatory T cells which show anergy and immunosuppressive activity in vitro. Furthermore, these Foxp3-transduced T cells prevent autoimmune thyroiditis transferred by pathogenic T cells in vivo. Our data indicates that Foxp3-transduced CD4+CD25− T cells may open new therapeutic strategies for immune disorders.

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Journal Cover

December 2006
Volume 18 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Wang S, Xu H, Wang Y, Ma J, Mao C, Shao Q, Ma B, Xu W and Yang S: Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. Int J Mol Med 18: 1193-1199, 2006.
APA
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q. ... Yang, S. (2006). Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. International Journal of Molecular Medicine, 18, 1193-1199. https://doi.org/10.3892/ijmm.18.6.1193
MLA
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q., Ma, B., Xu, W., Yang, S."Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice". International Journal of Molecular Medicine 18.6 (2006): 1193-1199.
Chicago
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q., Ma, B., Xu, W., Yang, S."Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice". International Journal of Molecular Medicine 18, no. 6 (2006): 1193-1199. https://doi.org/10.3892/ijmm.18.6.1193