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Increased expression of human histocompatibility leukocyte antigen-G in colorectal cancer cells.

  • Authors:
    • Y Fukushima
    • Y Oshika
    • M Nakamura
    • T Tokunaga
    • H Hatanaka
    • Y Abe
    • H Yamazaki
    • H Kijima
    • Y Ueyama
    • N Tamaoki

  • View Affiliations

  • Published online on: September 1, 1998     https://doi.org/10.3892/ijmm.2.3.349
  • Pages: 349-400
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Human histocompatibility leukocyte antigen (HLA)-G is a nonclassical major histocompatibility complex class I molecule. HLA-G is known to provide tolerance from recognition by natural killer cells. We studied HLA-G expression in 39 human colorectal cancers and 23 extra-neoplastic colon tissue samples by RT-PCR. The expression of HLA-G mRNA was significantly more frequent in colorectal cancer (34 of 39 cases) than in the extraneoplastic tissue (10 of 23 specimens; chi2 test, p = 0.0003). HLA-G expression was also confirmed on the cancer cells immunohistochemically. These results suggested that HLA-G on colorectal cancer cells may be correlated with escape from immunological surveillance during colon cancer development.

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Journal Cover

Sep 1998
Volume 2 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Fukushima Y, Oshika Y, Nakamura M, Tokunaga T, Hatanaka H, Abe Y, Yamazaki H, Kijima H, Ueyama Y, Tamaoki N, Tamaoki N, et al: Increased expression of human histocompatibility leukocyte antigen-G in colorectal cancer cells.. Int J Mol Med 2: 349-400, 1998.
APA
Fukushima, Y., Oshika, Y., Nakamura, M., Tokunaga, T., Hatanaka, H., Abe, Y. ... Tamaoki, N. (1998). Increased expression of human histocompatibility leukocyte antigen-G in colorectal cancer cells.. International Journal of Molecular Medicine, 2, 349-400. https://doi.org/10.3892/ijmm.2.3.349
MLA
Fukushima, Y., Oshika, Y., Nakamura, M., Tokunaga, T., Hatanaka, H., Abe, Y., Yamazaki, H., Kijima, H., Ueyama, Y., Tamaoki, N."Increased expression of human histocompatibility leukocyte antigen-G in colorectal cancer cells.". International Journal of Molecular Medicine 2.3 (1998): 349-400.
Chicago
Fukushima, Y., Oshika, Y., Nakamura, M., Tokunaga, T., Hatanaka, H., Abe, Y., Yamazaki, H., Kijima, H., Ueyama, Y., Tamaoki, N."Increased expression of human histocompatibility leukocyte antigen-G in colorectal cancer cells.". International Journal of Molecular Medicine 2, no. 3 (1998): 349-400. https://doi.org/10.3892/ijmm.2.3.349