Role of gut microbiota in the modulation of the health effects of advanced glycation end‑products (Review)

Aschner,Michael; Skalny,Anatoly V.; Gritsenko,Viktor A.; Kartashova,Olga L.; Santamaria,Abel; Rocha,Joao B.T.; Spandidos,Demetrios A.; Zaitseva,Irina P.; Tsatsakis,Aristidis; Tinkov,Alexey A.

doi:10.3892/ijmm.2023.5247

Role of gut microbiota in the modulation of the health effects of advanced glycation end‑products (Review)

Authors:
- Michael Aschner
- Anatoly V. Skalny
- Viktor A. Gritsenko
- Olga L. Kartashova
- Abel Santamaria
- Joao B.T. Rocha
- Demetrios A. Spandidos
- Irina P. Zaitseva
- Aristidis Tsatsakis
- Alexey A. Tinkov
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Affiliations: Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA, Sechenov University (IM Sechenov First Moscow State Medical University), Moscow 119435, Russia, Institute of Cellular and Intracellular Symbiosis, Ural Branch of The Russian Academy of Sciences, Orenburg 460000, Russia, Institute of Cellular and Intracellular Symbiosis, Ural Branch of The Russian Academy of Sciences, Orenburg 460000, Russia, Laboratory of Excitatory Amino Acids/Laboratory of Molecular Neuropharmacology and Nanotechnology, National Institute of Neurology and Neurosurgery, Mexico City 14269, Mexico, Department of Biochemistry and Molecular Biology, CCNE, Federal University of Santa Maria, Santa Maria, RS 97105‑900, Brazil, Laboratory of Clinical Virology, Medical School, University of Crete, 71409 Heraklion, Greece, Yaroslavl State University, Yaroslavl 150003, Russia
Published online on: April 11, 2023 https://doi.org/10.3892/ijmm.2023.5247
Article Number: 44
Copyright: © Aschner et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present review was to summarize the potential interactive effects between the gut microbiota and advanced glycation end‑product (AGE) accumulation and toxicity in the host, and to reveal potential the mediatory effects of the gut microbiota on AGE‑related health effects. The existing data demonstrate that dietary AGEs can have a significant impact on the richness and diversity of the gut microbiota, although the particular effect is dependent on the type of species, as well as the exposure dose. In addition, the gut microbiota may metabolize dietary AGEs. It has been also demonstrated that the characteristics of the gut microbiota, including its richness and relative abundance of certain taxa, is tightly associated with AGE accumulation in the host organism. In turn, a bilateral interplay between AGE toxicity and the modulation of the gut microbiota may contribute to pathogenesis of ageing and diabetes‑associated diseases. Bacterial endotoxin lipopolysaccharide appears as the molecule that mediates the interactions between the gut microbiota and AGE toxicity, specifically via the modulation of the receptor for AGE signaling. Therefore, it is proposed that the modulation of the gut microbiota using probiotics or other dietary interventions may have a significant impact on AGE‑induced glycative stress and systemic inflammation.

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