PANoptosis: Novel insight into regulated cell death and its potential role in cardiovascular diseases (Review)

Gao,Xinyu; Ma,Cuixue; Liang,Shan; Chen,Meihong; He,Yuan; Lei,Wei

doi:10.3892/ijmm.2024.5398

PANoptosis: Novel insight into regulated cell death and its potential role in cardiovascular diseases (Review)

Authors:
- Xinyu Gao
- Cuixue Ma
- Shan Liang
- Meihong Chen
- Yuan He
- Wei Lei
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Affiliations: Guangdong Provincial Engineering Technology Research Center for Molecular Diagnosis and Innovative Drugs Translation of Cardiopulmonary Vascular Diseases, University Joint Laboratory of Guangdong Province and Macao Region on Molecular Targets and Intervention of Cardiovascular Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China
Published online on: July 4, 2024 https://doi.org/10.3892/ijmm.2024.5398
Article Number: 74
Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

PANoptosis, a complex form of proinflammatory programmed cell death, including apoptosis, pyroptosis and necroptosis, has been an emerging concept in recent years that has been widely reported in cancer, infectious diseases and neurological disorders. Cardiovascular diseases (CVDs) are an important global health problem, posing a serious threat to individuals' lives. An increasing body of research shows that inflammation has a pivotal role in CVDs, which provides an important theoretical basis for PANoptosis to promote the progression of CVDs. To date, only sporadic studies on PANoptosis in CVDs have been reported and its role in the field of CVDs has not been fully explored. Elucidating the various modes of cardiomyocyte death, the specific molecular mechanisms and the links among the various modes of death under various stressful stimuli is of notable clinical significance for a deeper understanding of the pathophysiology of CVDs. The present review summarizes the molecular mechanisms of apoptosis, pyroptosis, necroptosis and PANoptosis and their prospects in the field of CVDs.

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