Open Access

Role of autophagy and ferroptosis in the development of endometriotic cysts (Review)

  • Authors:
    • Hiroshi Kobayashi
    • Shogo Imanaka
    • Chiharu Yoshimoto
    • Sho Matsubara
    • Hiroshi Shigetomi
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  • Published online on: July 11, 2024     https://doi.org/10.3892/ijmm.2024.5402
  • Article Number: 78
  • Copyright: © Kobayashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It is considered that the etiology of endometriosis is retrograde menstruation of endometrial tissue. Although shed endometrial cells are constantly exposed to a challenging environment with iron overload, oxidative stress and hypoxia, a few cells are able to survive and continue to proliferate and invade. Ferroptosis, an iron‑dependent form of non‑apoptotic cell death, is known to play a major role in the development and course of endometriosis. However, few papers have concentrated on the dynamic interaction between autophagy and ferroptosis throughout the progression of diseases. The present review summarized the current understanding of the mechanisms underlying autophagy and ferroptosis in endometriosis and discuss their role in disease development and progression. For the present narrative review electronic databases including PubMed and Google Scholar were searched for literature published up to the October 31, 2023. Autophagy and ferroptosis may be activated at early stages in endometriosis development. On the other hand, excessive activation of intrinsic pathways (e.g., estrogen and mechanistic target of rapamycin) may promote disease progression through autophagy inhibition. Furthermore, suppression of ferroptosis may cause further progression of endometriotic lesions. In conclusion, the autophagy and ferroptosis pathways may play a dual role in disease initiation and progression. The present review discussed the temporal transition of non‑apoptotic cell death regulation during disease progression from retrograde endometrium to early lesions to established lesions.
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September-2024
Volume 54 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kobayashi H, Imanaka S, Yoshimoto C, Matsubara S and Shigetomi H: Role of autophagy and ferroptosis in the development of endometriotic cysts (Review). Int J Mol Med 54: 78, 2024.
APA
Kobayashi, H., Imanaka, S., Yoshimoto, C., Matsubara, S., & Shigetomi, H. (2024). Role of autophagy and ferroptosis in the development of endometriotic cysts (Review). International Journal of Molecular Medicine, 54, 78. https://doi.org/10.3892/ijmm.2024.5402
MLA
Kobayashi, H., Imanaka, S., Yoshimoto, C., Matsubara, S., Shigetomi, H."Role of autophagy and ferroptosis in the development of endometriotic cysts (Review)". International Journal of Molecular Medicine 54.3 (2024): 78.
Chicago
Kobayashi, H., Imanaka, S., Yoshimoto, C., Matsubara, S., Shigetomi, H."Role of autophagy and ferroptosis in the development of endometriotic cysts (Review)". International Journal of Molecular Medicine 54, no. 3 (2024): 78. https://doi.org/10.3892/ijmm.2024.5402