Open Access

Circular RNAs in coronary heart disease: From molecular mechanism to promising clinical application (Review)

  • Authors:
    • Zengguang Fan
    • Xingxing Yuan
    • Ye Yuan
  • View Affiliations

  • Published online on: October 31, 2024     https://doi.org/10.3892/ijmm.2024.5452
  • Article Number: 11
  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Coronary heart disease (CHD) remains a leading cause of morbidity and mortality worldwide, posing a substantial public health burden. Despite advancements in treatment, the complex etiology of CHD necessitates ongoing exploration of novel diagnostic markers and therapeutic targets. Circular RNAs (circRNAs), a distinct class of non‑coding RNAs with a covalently closed loop structure, have emerged as significant regulators in various diseases, including CHD. Their high stability, tissue‑specific expression and evolutionary conservation underscore their potential as biomarkers and therapeutic agents in CHD. This review discusses the current knowledge on circRNAs in the context of CHD and explores the molecular mechanisms by which circRNAs influence the pathophysiology of CHD, including cardiomyocyte death, endothelial injury, vascular dysfunction and inflammation. It also summarizes the emerging evidence highlighting the differential expression of circRNAs in patients with CHD and their potential utilities as non‑invasive diagnostic and prognostic biomarkers and therapeutic targets for this disease.
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January-2025
Volume 55 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Fan Z, Yuan X and Yuan Y: Circular RNAs in coronary heart disease: From molecular mechanism to promising clinical application (Review). Int J Mol Med 55: 11, 2025.
APA
Fan, Z., Yuan, X., & Yuan, Y. (2025). Circular RNAs in coronary heart disease: From molecular mechanism to promising clinical application (Review). International Journal of Molecular Medicine, 55, 11. https://doi.org/10.3892/ijmm.2024.5452
MLA
Fan, Z., Yuan, X., Yuan, Y."Circular RNAs in coronary heart disease: From molecular mechanism to promising clinical application (Review)". International Journal of Molecular Medicine 55.1 (2025): 11.
Chicago
Fan, Z., Yuan, X., Yuan, Y."Circular RNAs in coronary heart disease: From molecular mechanism to promising clinical application (Review)". International Journal of Molecular Medicine 55, no. 1 (2025): 11. https://doi.org/10.3892/ijmm.2024.5452