Role of the m<sup>6</sup>A demethylase ALKBH5 in gastrointestinal tract cancer (Review)

Zhang,Lumiao; Jing,Mengjia; Song,Qianben; Ouyang,Yiming; Pang,Yingzhi; Ye,Xilin; Fu,Yu; Yan,Wei

doi:10.3892/ijmm.2024.5463

Role of the m⁶A demethylase ALKBH5 in gastrointestinal tract cancer (Review)

Authors:
- Lumiao Zhang
- Mengjia Jing
- Qianben Song
- Yiming Ouyang
- Yingzhi Pang
- Xilin Ye
- Yu Fu
- Wei Yan
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Affiliations: Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
Published online on: November 25, 2024 https://doi.org/10.3892/ijmm.2024.5463
Article Number: 22
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

N6‑methyladenosine (m⁶A) is one of the most universal, abundant and conserved types of internal post‑transcriptional modifications in eukaryotic RNA, and is involved in nuclear RNA export, RNA splicing, mRNA stability, gene expression, microRNA biogenesis and long non‑coding RNA metabolism. AlkB homologue 5 (ALKBH5) acts as a m6A demethylase to regulate a wide variety of biological processes closely associated with tumour progression, tumour metastasis, tumour immunity and tumour drug resistance. ALKBH5 serves a crucial role in human digestive system tumours, mainly through post‑transcriptional regulation of m⁶A modification. The present review discusses progress in the study of the m6A demethylase ALKBH5 in gastrointestinal tract cancer, summarizes the potential molecular mechanisms of ALKBH5 dysregulation in gastrointestinal tract cancer, and discusses the significance of ALKBH5‑targeted therapy, which may provide novel ideas for future clinical prognosis prediction, biomarker identification and precise treatment.

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