Open Access

Role of GLP‑1 receptor agonists in sepsis and their therapeutic potential in sepsis‑induced muscle atrophy (Review)

  • Authors:
    • Xuan Zhao
    • Yukun Liu
    • Dongfang Wang
    • Tonghan Li
    • Zhikai Xu
    • Zhanfei Li
    • Xiangjun Bai
    • Yuchang Wang
  • View Affiliations

  • Published online on: March 5, 2025     https://doi.org/10.3892/ijmm.2025.5515
  • Article Number: 74
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sepsis‑induced myopathy (SIM) is a common complication in intensive care units, which is often associated with adverse outcomes, primarily manifested as skeletal muscle weakness and atrophy. Currently, the management of SIM focuses on prevention strategies, as effective therapeutic options remain elusive. Glucagon‑like peptide‑1 (GLP‑1) receptor agonists (GLP‑1RAs) have garnered attention as hypoglycemic and weight‑loss agents, with an increasing body of research focusing on the extrapancreatic effects of GLP‑1. In preclinical settings, GLP‑1RAs exert protective effects against sepsis‑related multiple organ dysfunction through anti‑inflammatory and antioxidant mechanisms. Based on the existing research, we hypothesized that GLP‑1RAs may serve potential protective roles in the repair and regeneration of skeletal muscle affected by sepsis. The present review aimed to explore the relationship between GLP‑1RAs and sepsis, as well as their impact on muscle atrophy‑related myopathy. Furthermore, the potential mechanisms and therapeutic benefits of GLP‑1RAs are discussed in the context of muscle atrophy induced by sepsis.
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May-2025
Volume 55 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao X, Liu Y, Wang D, Li T, Xu Z, Li Z, Bai X and Wang Y: Role of GLP‑1 receptor agonists in sepsis and their therapeutic potential in sepsis‑induced muscle atrophy (Review). Int J Mol Med 55: 74, 2025.
APA
Zhao, X., Liu, Y., Wang, D., Li, T., Xu, Z., Li, Z. ... Wang, Y. (2025). Role of GLP‑1 receptor agonists in sepsis and their therapeutic potential in sepsis‑induced muscle atrophy (Review). International Journal of Molecular Medicine, 55, 74. https://doi.org/10.3892/ijmm.2025.5515
MLA
Zhao, X., Liu, Y., Wang, D., Li, T., Xu, Z., Li, Z., Bai, X., Wang, Y."Role of GLP‑1 receptor agonists in sepsis and their therapeutic potential in sepsis‑induced muscle atrophy (Review)". International Journal of Molecular Medicine 55.5 (2025): 74.
Chicago
Zhao, X., Liu, Y., Wang, D., Li, T., Xu, Z., Li, Z., Bai, X., Wang, Y."Role of GLP‑1 receptor agonists in sepsis and their therapeutic potential in sepsis‑induced muscle atrophy (Review)". International Journal of Molecular Medicine 55, no. 5 (2025): 74. https://doi.org/10.3892/ijmm.2025.5515